Pharmatex vaginal cream 1.2%, 72g

Local contraception.

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

It is administered intravaginally for 5-10 minutes (depending on the dosage form used) before intercourse.

benzalkonium chloride 50% aqueous solution 2.4 g, which corresponds to a benzalkonium chloride content of 1.2 g

Excipients: citric acid - 0.002 g, disodium hydrogen phosphate dodecahydrate - up to pH 3.5-5.5, macrogol and ethylene glycol palmitostearate (TefosЃ 63) - 24 g, lavender oil - 0.05 g, purified water - up to 100 g.

Hypersensitivity to benzalkonium chloride;

vaginitis,

ulceration and irritation of the vaginal mucosa and cervix.

Clinical and pharmacological group: Vaginal contraceptive with spermicidal action

Pharmaco-therapeutic group: Contraceptive for topical use

pharmachologic effect

Antiseptic with spermicidal action. It is a quaternary ammonium compound, belongs to cationic surfactants.

The spermicidal effect is due to the ability of the active substance to destroy the membranes of spermatozoa (first flagella, then heads), which leads to the impossibility of fertilizing an egg with a damaged sperm.

The effect develops within 5-10 minutes after insertion into the vagina.

Does not affect the normal microflora of the vagina and the menstrual cycle.

In vitro benzalkonium chloride is active against Neisseria gonorrhoeae, Chlamydia spp., Trichomonas vaginalis, Herpes simplex type 2, Staphylococcus aureus. It is not very active against Gardnerella vaginalis, Candida albicans, Haemophilus ducreyi and Treponema pallidum. Not active against Mycoplasma spp.

Pharmacokinetics

Benzalkonium chloride is not absorbed into the vaginal mucosa, it is removed by simple rinsing with water and with normal physiological secretions. When applied topically, it is practically not absorbed.

Indications

Local contraception.

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

It is administered intravaginally for 5-10 minutes (depending on the dosage form used) before intercourse.

Side effect

Possibly: allergic reactions, contact dermatitis, burning sensation, itching in the vagina and / or the partner's penis, painful urination.

Contraindications for use

Hypersensitivity to benzalkonium chloride;

vaginitis,

ulceration and irritation of the vaginal mucosa and cervix.

Application during pregnancy and lactation

Not applicable during pregnancy. Does not adversely affect the course of pregnancy. It is not excreted in breast milk, can be used during breastfeeding.

special instructions

The effectiveness of contraception depends on the correct use of the drug containing benzalkonium chloride.

In case of vaginal diseases, the use of benzalkonium chloride should be temporarily discontinued until the end of treatment with vaginal drugs.

This method of contraception does not protect against sexually transmitted infections or HIV-related infections.

It is forbidden to use soap for the toilet of the genitals 2 hours before and 2 hours after intercourse, because soap destroys benzalkonium chloride. Vaginal irrigation is used 2 hours after intercourse.

Drug interactions

Any drug used intravaginally can reduce the spermicidal effect of benzalkonium chloride.

Benzalkonium chloride is destroyed by soap.

Iodine solutions (including 0.1% iodonate solution) inactivate benzalkonium chloride.