Pentoxifylline | trental tablets coated with enteric-soluble captivity 100 mg 60 pcs.

Special Price $21.34 Regular Price $30.00
In stock
SKU
BID494257
426.8 Reward Points will be used to purchase this product
Latin name

TRENTAL
Latin name

TRENTAL

Release form

Enteric-coated film-coated tablets.

Packaging

60 per pack .

Pharmacological action

Pharmacodynamics

A drug that improves microcirculation, angioprotector, xanthine derivative. Trental improves the rheological properties of blood (fluidity) due to the effect on the pathologically altered deformability of red blood cells, inhibiting platelet aggregation and reducing high blood viscosity. Improves microcirculation in areas of impaired circulation.

The mechanism of action of pentoxifylline is associated with the inhibition of phosphodiesterase and the accumulation of cAMP in the smooth muscle cells of blood vessels and blood cells.

Having a weak myotropic vasodilating effect, pentoxifylline somewhat reduces OPSS and slightly dilates the coronary vessels.

Treatment with Trental improves the symptoms of cerebrovascular accidents.

The success of treatment with occlusive lesions of the peripheral arteries (for example, intermittent claudication) is manifested in lengthening the walking distance, eliminating night cramps in the calf muscles and the disappearance of pain at rest.

Pharmacokinetics

Absorption

After oral administration, pentoxifylline is almost completely absorbed from the gastrointestinal tract.

Bioavailability averages 19%.

Metabolism

The main pharmacologically active metabolite of 1- (5-hydroxyhexyl) -3,7-dimethylxanthine is determined in plasma at a concentration exceeding 2 times the concentration of unchanged substance, and is in a state of reversible biochemical equilibrium with it. For this reason, pentoxifylline and its metabolite should be considered as an active whole, therefore, we can assume that the bioavailability of the active substance is significantly higher. Pentoxifylline is completely biotransformed in the body.

Excretion of

T1 / 2 of pentoxifylline is 1.6 hours.

More than 90% is excreted by the kidneys as unconjugated, water-soluble polar metabolites.

Pharmacokinetics in special clinical cases

In patients with severe impaired renal function, the excretion of metabolites is slowed down.

In patients with impaired liver function, an extension of T1 / 2 of pentoxifylline and an increase in its bioavailability were noted.

Indications

Peripheral circulatory disorders of atherosclerotic origin (e.g. intermittent claudication)

diabetic angiopathy

trophic disorders (e.g. lower leg ulcers, gangrene)

cerebrovascular accidents, such as cerebrospinal disorders, such as cerebrospinal disorders, such as cerebrospinal disorders, e.g. memory impairment)

ischemic and post-stroke conditions

circulatory disorders in the retina and choroid

otosclerosis

degenerative changes due to vascular pathology of the inner ear and hearing loss.

Contraindications

Hypersensitivity to the components of the

drug massive bleeding

extensive retinal hemorrhage

cerebral hemorrhage

acute myocardial infarction

age up to 18 years old mr pregnancy and other pregnancy and other pregnancy.

Caution should be used in patients with: severe cardiac arrhythmias (risk of worsening arrhythmias), arterial hypotension (risk of further decrease in blood pressure), chronic heart failure, with peptic ulcer of the stomach and duodenum, impaired renal function - CC less than 30 ml / min (the risk of cumulation and an increased risk of side effects), with severe impaired liver function (the risk of cumulation and an increased risk of side effects), an increased tendency to bleeding, including as a result of the use of anticoagulants or with violations of the blood coagulation system (risk of developing more severe bleeding), after recently undergoing surgical interventions.

Use during pregnancy and lactation

The drug is contraindicated in pregnancy.

If you need to use the drug during lactation, you should stop breastfeeding.

Composition

1 tablet contains:

Active substances: pentoxifylline 100 mg.

Excipients: lactose, starch, talc, colloidal silicon dioxide, magnesium stearate.

Shell composition: methacrylic acid copolymer, sodium hydroxide, macrogol (polyethylene glycol) 8000, talc, titanium dioxide (E171).

Dosage and administration

Dose is set individually, in accordance with the characteristics of the patient.

The drug is administered orally at 100 mg (1 tab.) 3 times / day, followed by a gradual increase in dose to 200 mg 2-3 times / day. The maximum single dose is 400 mg. The maximum daily dose is 1200 mg. The tablets should be swallowed whole during or immediately after a meal with a sufficient amount of water.

In patients with impaired renal function (CC less than 30 ml / min), the dose should be reduced to 1-2 tablets / day.

In patients with severely impaired liver function, a dose reduction is necessary taking into account the individual tolerance of the drug.

In patients with low blood pressure, as well as in individuals at risk due to a possible decrease in blood pressure (patients with severe coronary artery disease or with hemodynamically significant stenosis of the cerebral vessels), treatment can be started in small doses, in these cases the dose should be increased gradually.

Side effects

From the central nervous system: headache, dizziness, anxiety, sleep disturbances, convulsions very rarely - aseptic meningitis.

Dermatological reactions: flushing of the face, flushing of the face and upper chest, swelling, increased fragility of the nails.

From the digestive system: xerostomia, anorexia, intestinal atony, a feeling of pressure and overflow in the stomach, nausea, vomiting, diarrhea in some cases - intrahepatic cholestasis and increased activity of hepatic transaminases (AST, ALT), alkaline phosphatase.

From the cardiovascular system: tachycardia, arrhythmia, cardialgia, progression of angina pectoris, decreased blood pressure.

From the hematopoietic system: leukopenia, thrombocytopenia, pancytopenia, bleeding from blood vessels of the skin, mucous membranes, stomach, intestines, hypofibrinogenemia.

From the side of the organ of vision: visual impairment, scotoma.

Allergic reactions: itching, flushing of the skin, urticaria, angioedema, anaphylactic shock.

Side effects are possible with Trental in high doses.

Drug Interaction

Pentoxifylline is able to potentiate the effects of drugs that reduce blood pressure (ACE inhibitors, nitrates).

Pentoxifylline can increase the effect of drugs that affect the blood coagulation system (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins).

Cimetidine increases the concentration of pentoxifylline in plasma (risk of side effects).

Co-administration with other xanthines can lead to excessive nervous excitation.

Increased hypoglycemic effects of insulin or oral hypoglycemic agents with pentoxifylline (increased risk of hypoglycemia). If combination therapy is required, strict monitoring of the patient's condition is required.

In some patients, concomitant administration of pentoxifylline and theophylline may lead to increased plasma concentrations of theophylline. This can lead to an increase or increase in the side effect associated with theophylline.

Overdose

Symptoms: nausea, dizziness, tachycardia, decreased blood pressure, arrhythmia, hyperemia of the skin, chills, loss of consciousness, areflexia, tonic-clonic convulsions.

Treatment: Symptomatic therapy is carried out if necessary. The patient should be given a horizontal position with legs raised. The specific antidote is unknown. They monitor the vital functions of the body and general activities aimed at maintaining them, monitor the patency of the respiratory tract. In convulsions - diazepam.

Storage conditions

Store in a dry place at a temperature not exceeding 25 РC.

Keep out of the reach of children.

Expiration

4 years.

Deystvuyuschee substances

Pentoxifylline



pharmacy terms for prescription

dosage form

dosage form

tablets

Sanofi India Ltd, India

Submit your review to Earn 10 Reward Points click here to login

Write Your Own Review
You're reviewing:Pentoxifylline | trental tablets coated with enteric-soluble captivity 100 mg 60 pcs.

 Job in company (10-20 minutes a day | 400 - 1200 USD)! 

We are looking for partners!

 If you have PayPal and you are ready to earn in our team - contact us: [email protected] 

Copyright © 2011-2024 Buy-Pharm, Inc. All rights reserved.