Papazol tablets 30 + 30mg, No. 20

• Arterial hypertension (labile);

• spasm of peripheral arteries and cerebral vessels;

• spasm of smooth muscles of internal organs (including peptic ulcer of the stomach and duodenum, pyloric spasm, intestinal colic, cholecystitis, spastic colitis);

• poliomyelitis (residual effects);

• peripheral paralysis of the facial nerve.

Inside for adults - 1-2 tab. 2-3 times / day

Tablets 1 tab.

papaverine hydrochloride 30 mg

bendazole 30 mg

• Violations of AV conduction;

• epileptic syndrome;

• broncho-obstructive syndrome;

• children's age up to 1 year;

• hypersensitivity to the components of the drug.

• It is prescribed with caution in case of decreased intestinal motility, traumatic brain injury, hepatic and / or renal failure, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, during pregnancy and lactation.

pharmachologic effect

The combined drug has an antispasmodic, hypotensive, vasodilating effect. Bendazol is a myotropic antispasmodic agent; has a hypotensive, vasodilating effect, stimulates the function of the spinal cord, has a moderate immunostimulating activity. Papaverine is an antispasmodic agent that has a hypotensive effect. Inhibits phosphodiesterase, causes the accumulation of cAMP in the cell and a decrease in calcium content, reduces tone and relaxes the smooth muscles of the internal organs (gastrointestinal tract, respiratory and genitourinary systems) and blood vessels. In large doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction. The effect on the central nervous system is weak (in large doses it has a sedative effect).

Side effect

From the digestive system: nausea, constipation. From the side of the central nervous system: dizziness. From the side of the cardiovascular system: AV blockade, arrhythmias, decreased myocardial contractility. Others: allergic reactions, increased sweating.

Application during pregnancy and lactation

It is prescribed with caution during pregnancy and lactation.

Application for violations of liver function

Contraindicated in liver failure.

Application for impaired renal function

Contraindicated in renal failure.

Application in children

Contraindicated in children under 1 year of age.

special instructions

The safety of using the drug during pregnancy and lactation has not been established.

Drug interactions

With the simultaneous use of the drug with antispasmodics, sedatives, diuretics, tricyclic antidepressants, procainamide, reserpine, quinidine, an increase in the severity of the hypotensive effect is possible. Papazol weakens the effect of anticholinesterase drugs on smooth muscles (galantamine, proserin, physiostigmine). Adsorbents, astringent and enveloping drugs reduce the absorption of the drug in the gastrointestinal tract.