Pantogam tablets 250mg, No. 50

• cognitive impairment in organic brain lesions, including the consequences of neuroinfections and traumatic brain injuries, and neurotic disorders;

• schizophrenia with cerebral organic failure;

• extrapyramidal disorders (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) caused by the use of antipsychotics;

• epilepsy with a slowdown in mental processes in complex therapy with anticonvulsants;

• psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization;

• neurogenic urination disorders (pollakiuria, urgency, urinary incontinence, enuresis);

• children with developmental delay (mental, speech, motor or their combination), including against the background of previous perinatal encephalopathy and in children with various forms of cerebral palsy;

• children with hyperkinetic disorders (attention deficit hyperactivity disorder);

• children with neurosis-like conditions (tics; stuttering, mainly with a clonic form).

Inside, 15-30 minutes after eating.

A single dose for adults is usually 0.25-1 g (1-4 tablets), for children - 0.25-0.5 g (1-2 tablets); the daily dose for adults is 1.5-3 g (6-12 tablets), for children - 0.75-3 g (3-12 tablets). The course of treatment is from 1 to 4 months, in some cases - up to 6 months. A second course of treatment is possible in 3-6 months.

For cognitive impairment with organic brain lesions, including the consequences of neuroinfections and traumatic brain injuries, and neurotic disorders: 0.25 g (1 tablet) 3-4 times a day.

For extrapyramidal disorders (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.): in a dose of 0.5 to 3 g (2-12 tablets) per day. The course of treatment is up to 4 months or more.

In the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) caused by the use of antipsychotics, in schizophrenia with cerebral organic insufficiency: for adults - in a dose of 0.5 to 1 g (2-4 tablets) 3 times a day; children - at a dose of 0.25 to 0.5 g (1-2 tablets) 3-4 times a day. The course of treatment is 1-3 months.

For epilepsy with a slowdown in mental processes in complex therapy with anticonvulsants: for adults - in a dose of 0.5 to 1 g (2-4 tablets) 3 times a day; children - at a dose of 0.25 to 0.5 g (1-2 tablets) 3-4 times a day. The course of treatment is up to 6 months.

With psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization: 0.25 g (1 tablet) 3 times a day.

For neurogenic urination disorders: for adults - in a dose of 0.5 to 1 g (2-4 tablets) 2-3 times a day; children - at a dose of 0.25 to 0.5 g (1-2 tablets) 3 times a day (the daily dose is 25-50 mg / kg). The course of treatment is 1-3 months.

For children with various pathologies of the nervous system , depending on age, the drug is recommended to take up to 3 g per day (12 tablets). Tactics for prescribing the drug: increasing the dose for 7-12 days, taking it at the maximum dose for 15-40 days and gradually reducing the dose until PantogamЃ is canceled for 7-8 days. The break between PantogamЃ courses, as for any other nootropic drug, is from 1 to 3 months.

Children with developmental delay: 0.5 g (2 tablets) 3-4 times a day. The course of treatment is 2-3 months.

Children with attention deficit hyperactivity disorder: at a dose of 0.25 to 1 g (1-4 tablets) 1-2 times a day in the morning and in the afternoon with dose titration for the first 5-7 days (the average therapeutic dose is 30 mg / kg of the child's body weight per day). The course of treatment is 3-4 months.

Children with neurosis-like conditions (tics; stuttering, mainly in the clonic form): in a dose of 0.25 to 0.5 g (1-2 tablets) 3-6 times a day. The course of treatment is 1-4 months.

Taking into account the nootropic effect of the drug, its administration is carried out preferably in the morning and afternoon hours (up to 17 hours).

The drug is used in children over 3 years old. At an earlier age, it is recommended to take the drug in the form of a syrup.

Active ingredient: calcium hopantenat (PantogamЃ) 250 mg;

Excipients: methylcellulose 0.8 mg, calcium stearate 3.1 mg, magnesium hydroxycarbonate 46.8 mg, talc 9.3 mg.

• hypersensitivity;

• acute severe kidney disease;

• pregnancy;

• breastfeeding period;

• children up to age 3 years.

Precautions

In conditions of long-term treatment, the simultaneous administration of the drug with other nootropic and stimulating agents is not recommended.

Trade name:

PantogamЃ

International non-proprietary name:

hopantenic acid

Dosage form:

pills.

Description:

tablets are white, flat-cylindrical, with a chamfer and a score.

Composition for one tablet:

Active ingredient: calcium hopantenat (PantogamЃ) 250 mg;

Excipients: methylcellulose 0.8 mg, calcium stearate 3.1 mg, magnesium hydroxycarbonate 46.8 mg, talc 9.3 mg.

Active substance:

calcium hopantenate 500 mg

Excipients: methylcellulose - 1.6 mg, calcium stearate - 6.2 mg, magnesium hydroxycarbonate - 93.6 mg, talc - 18.6 mg.

Pharmacotherapeutic group:

nootropic agent.

Pharmacological properties

Pharmacodynamics.The spectrum of action of PantogamЃ is associated with the presence of gamma-aminobutyric acid in its structure. The mechanism of action is due to the direct influence of PantogamЃ on the GABAB-receptor-channel complex. The drug has a nootropic and anticonvulsant effect. PantogamЃ increases the brain's resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability, and activates mental and physical performance. Improves GABA metabolism in chronic alcohol intoxication and after ethanol withdrawal. It is able to inhibit acetylation reactions involved in the mechanisms of inactivation of procaine (novocaine) and sulfonamides, due to which the prolongation of the action of the latter is achieved.It causes inhibition of the pathologically increased gallbladder reflex and detrusor tone.

Pharmacokinetics. PantogamЃ is rapidly absorbed from the gastrointestinal tract, penetrates the blood-brain barrier, the highest concentrations are created in the liver, kidneys, stomach wall and skin. The drug is not metabolized and is excreted unchanged within 48 hours: 67.5% of the dose taken - with urine, 28.5% - with feces.

Indications for use

• cognitive impairment in organic brain lesions, including the consequences of neuroinfections and traumatic brain injuries, and neurotic disorders;

• schizophrenia with cerebral organic failure;

• extrapyramidal disorders (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) caused by the use of antipsychotics;

• epilepsy with a slowdown in mental processes in complex therapy with anticonvulsants;

• psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization;

• neurogenic urination disorders (pollakiuria, urgency, urinary incontinence, enuresis);

• children with developmental delay (mental, speech, motor or their combination), including against the background of previous perinatal encephalopathy and in children with various forms of cerebral palsy;

• children with hyperkinetic disorders (attention deficit hyperactivity disorder);

• children with neurosis-like conditions (tics; stuttering, mainly with a clonic form).

Contraindications

• hypersensitivity;

• acute severe kidney disease;

• pregnancy;

• breastfeeding period;

• children up to age 3 years.

Precautions

In conditions of long-term treatment, the simultaneous administration of the drug with other nootropic and stimulating agents is not recommended.

Application during pregnancy and during breastfeeding

The use of the drug during pregnancy and during breastfeeding is not recommended due to the lack of clinical experience in this category of patients.

Method of administration and dosage

Inside, 15-30 minutes after eating.

A single dose for adults is usually 0.25-1 g (1-4 tablets), for children - 0.25-0.5 g (1-2 tablets); the daily dose for adults is 1.5-3 g (6-12 tablets), for children - 0.75-3 g (3-12 tablets). The course of treatment is from 1 to 4 months, in some cases - up to 6 months. A second course of treatment is possible in 3-6 months.

For cognitive impairment with organic brain lesions, including the consequences of neuroinfections and traumatic brain injuries, and neurotic disorders: 0.25 g (1 tablet) 3-4 times a day.

For extrapyramidal disorders (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.): in a dose of 0.5 to 3 g (2-12 tablets) per day. The course of treatment is up to 4 months or more.

In the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) caused by the use of antipsychotics, in schizophrenia with cerebral organic insufficiency: for adults - in a dose of 0.5 to 1 g (2-4 tablets) 3 times a day; children - at a dose of 0.25 to 0.5 g (1-2 tablets) 3-4 times a day. The course of treatment is 1-3 months.

For epilepsy with a slowdown in mental processes in complex therapy with anticonvulsants: for adults - in a dose of 0.5 to 1 g (2-4 tablets) 3 times a day; children - at a dose of 0.25 to 0.5 g (1-2 tablets) 3-4 times a day. The course of treatment is up to 6 months.

With psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization: 0.25 g (1 tablet) 3 times a day.

For neurogenic urination disorders: for adults - in a dose of 0.5 to 1 g (2-4 tablets) 2-3 times a day; children - at a dose of 0.25 to 0.5 g (1-2 tablets) 3 times a day (the daily dose is 25-50 mg / kg). The course of treatment is 1-3 months.

For children with various pathologies of the nervous system , depending on age, the drug is recommended to take up to 3 g per day (12 tablets). Tactics for prescribing the drug: increasing the dose for 7-12 days, taking it at the maximum dose for 15-40 days and gradually reducing the dose until PantogamЃ is canceled for 7-8 days. The break between PantogamЃ courses, as for any other nootropic drug, is from 1 to 3 months.

Children with developmental delay: 0.5 g (2 tablets) 3-4 times a day. The course of treatment is 2-3 months.

Children with attention deficit hyperactivity disorder: at a dose of 0.25 to 1 g (1-4 tablets) 1-2 times a day in the morning and in the afternoon with dose titration for the first 5-7 days (the average therapeutic dose is 30 mg / kg of the child's body weight per day). The course of treatment is 3-4 months.

Children with neurosis-like conditions (tics; stuttering, mainly in the clonic form): in a dose of 0.25 to 0.5 g (1-2 tablets) 3-6 times a day. The course of treatment is 1-4 months.

Taking into account the nootropic effect of the drug, its administration is carried out preferably in the morning and afternoon hours (up to 17 hours).

The drug is used in children over 3 years old. At an earlier age, it is recommended to take the drug in the form of a syrup.

Side effect

The adverse reactions presented below are listed in accordance with the damage to organs and systems and the frequency of occurrence. The frequency of occurrence is determined as follows: very often (? 1/10), often (? 1/100 and <1/10), infrequently (? 1/1000 and <1/100), rarely (? 1/10 000 and <1/1000), very rare (<1/10000, including isolated cases).

Immune system disorders. Very rare: allergic reactions (rhinitis, conjunctivitis, allergic skin reactions).

Nervous system disorders. Very rare: hyperexcitation, headache, dizziness, noise in the head.

Mental disorders. Very rare: lethargy, lethargy, sleep disturbances, drowsiness.

In case of disorders of the immune system, the drug is canceled. In other cases, reduce the dose of the drug.

Overdose

Symptoms: sleep disturbances or drowsiness, noise in the head.

Treatment: activated carbon, gastric lavage, symptomatic therapy.

Interaction with other medicinal products

Prolongs the action of barbiturates, enhances the action of anticonvulsants, prevents the side effects of phenobarbital, carbamazepine, antipsychotics. The effect of PantogamЃ is enhanced in combination with glycine, etidronic acid. Potentiates the action of local anesthetics (procaine).

Influence on the ability to drive vehicles, mechanisms

In the first days of taking the drug, care should be taken when driving vehicles and mechanisms, given the possible occurrence of drowsiness (see section 'Side effects').

Release form

Tablets 250 mg. 10 tablets in a blister made of polyvinyl chloride film and aluminum foil. 5 blister strip packs together with instructions for use are placed in a carton box.

Shelf life

4 years.
Do not use after the expiration date printed on the package.

Storage conditions

At a temperature not higher than 25 ? C.
Keep out of the reach of children.

Vacation conditions

Dispensed by prescription.