Pantogam syrup 10%, 100ml

- children with perinatal encephalopathy from the first days of life;

- various forms of cerebral palsy;

- mental retardation of varying severity, including those with behavioral disorders;

- violations of the psychological status in children in the form of a general delay in mental development, specific speech disorders, motor functions and their combination, the formation of school skills (reading, writing, counting, etc.);

- hyperkinetic disorders, including attention deficit hyperactivity disorder;

- neurosis-like states (with stuttering, predominantly clonic form, tics, inorganic encopresis and enuresis);

- a decrease in mnestic and intellectual productivity due to arteriosclerotic changes in the vessels of the brain, with the initial forms of senile dementia, organic brain lesions of traumatic, toxic, neuroinfectious genesis;

- schizophrenia with cerebral organic insufficiency (in combination with psychotropic drugs);

- extrapyramidal disorders in organic brain diseases (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment and prevention of extrapyramidal syndrome caused by the use of neuroleptics;

- epilepsy with retardation of mental processes and a decrease in cognitive productivity in conjunction with anticonvulsants;

- psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization;

- neurogenic disorders of urination (pollakiuria, urgency, urge incontinence).

Pantogam syrup 100 mg / ml is taken orally 15-30 minutes after a meal. A single dose for adults is usually 2.5 - 10 ml (0.25 - 1 g), for children - 2.5 - 5 ml (0.25 - 0.5 g); the daily dose for adults is 15-30 ml (1.5-3 g), for children - 7.5-30 ml (0.75-3 g). The course of treatment is 1 - 4 months, sometimes up to 6 months. After 3 - 6 months, a second course of treatment is possible.

For children, depending on the age and pathology of the nervous system, the following dose range is recommended: children of the first year - 5 - 10 ml (0.5 - 1 g) per day, up to 3 years old - 5 - 12.5 ml (0.5 - 1.25 g) per day, for children from 3 to 7 years old - 7.5-15 ml (0.75 - 1.5 g), over 7 years old - 10 - 20 ml (1 - 2 g). The treatment tactics provides for increasing the dose within 7 to 12 days, taking the maximum dose for 15 to 40 days or more with a gradual decrease in the dose until it is canceled within 7 to 8 days. The course of treatment is 30 - 90 days (for certain diseases up to 6 months or more).

For schizophrenia in combination with psychotropic drugs - from 5 to 30 ml (0.5 to 3 g) per day. The course of therapy is from 1 to 3 months. For epilepsy, in combination with anticonvulsants - at a dose of 7.5 to 10 ml (0.75 - 1 g) per day. The course of therapy is up to 1 year or more. With neuroleptic syndrome, accompanied by extrapyramidal disorders, the daily dose is up to 30 ml (up to 3 g), treatment for several months. With extrapyramidal hyperkinesis in patients with organic diseases of the nervous system - from 5 to 30 ml (0.5 to 3 g) per day. The course of treatment is up to 4 months or more.

With the consequences of neuroinfections and traumatic brain injuries - from 5 to 30 ml (0.5 - 3 g) per day.

To restore working capacity at increased loads and asthenic conditions, Pantogam is prescribed 2.5 - 5 ml (0.25 - 0.5 g) 3 times a day.

For urination disorders for children - 2.5 - 5 ml (0.25 - 0.5 g), the daily dose is 25 - 50 mg / kg, the course of treatment is 1 - 3 months; adults - 5 - 10 ml (0.5 - 1 g) 2 - 3 times a day.

In conditions of long-term treatment, the simultaneous administration of the drug with other nootropic and stimulating agents is not recommended. Taking into account the nootropic effect of the drug, its administration is preferably carried out in the morning and afternoon hours.

active substance: calcium hopantenate (PantogamЃ) - 10.0 g;
excipients: glycerol (in terms of 100%) 25.8 g, sorbitol 15.0 g, citric acid monohydrate 0.1 g, sodium benzoate 0.1 g, aspartame 0.05 g, food flavoring 'Cherry 667' 0 , 01 g, purified water - up to 100 ml.

Hypersensitivity to the drug, acute severe kidney disease, pregnancy (1 trimester), phenylketonuria (syrup contains aspartame).

Trade name of the drug

PantogamЃ

International non-proprietary name

hopantenic acid (acidum hopantenicum)

Dosage form

syrup

Composition:

active substance: calcium hopantenate (PantogamЃ) - 10.0 g;
excipients: glycerol (in terms of 100%) 25.8 g, sorbitol 15.0 g, citric acid monohydrate 0.1 g, sodium benzoate 0.1 g, aspartame 0.05 g, food flavoring 'Cherry 667' 0 , 01 g, purified water - up to 100 ml.

Description

Colorless or slightly yellowish liquid with a cherry smell

Pharmacotherapeutic group - nootropic agent

Pharmacological properties

Pharmacodynamics.

The spectrum of action of pantogam is associated with the presence of gamma-aminobutyric acid in its structure. The mechanism of action is due to the direct influence of pantogam on GABA - the receptor-channel complex. The drug has a nootropic and anticonvulsant effect. Pantogam increases the brain's resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability, activates mental and physical performance. Improves GABA metabolism in chronic alcohol intoxication and after ethanol withdrawal. It is able to inhibit the acetylation reactions involved in the mechanisms of inactivation of novocaine and sulfonamides, due to which the prolongation of the action of the latter is achieved.It causes inhibition of the pathologically increased gallbladder reflex and detrusor tone.

Pharmacokinetics.

Pantogam is rapidly absorbed from the gastrointestinal tract, penetrates the blood-brain barrier, the highest concentrations are created in the liver, kidneys, stomach wall and skin. The drug is not metabolized and is excreted unchanged within 48 hours: 67.5% of the dose taken is excreted by the kidneys, 28.5% is excreted in feces.

Indications for use

• children with perinatal encephalopathy from the first days of life;

• various forms of cerebral palsy;

• mental retardation of varying severity, including those with behavioral disorders;

• violations of the psychological status in children in the form of a general delay in mental development, specific speech disorders, motor functions and their combination, the formation of school skills (reading, writing, counting, etc.);

• hyperkinetic disorders, including attention deficit hyperactivity disorder;

• neurosis-like states (with stuttering, predominantly clonic form, tics, inorganic encopresis and enuresis);

• a decrease in mnestic and intellectual productivity due to arteriosclerotic changes in the vessels of the brain, with the initial forms of senile dementia, organic brain lesions of traumatic, toxic, neuroinfectious genesis;

• schizophrenia with cerebral organic failure (in combination with psychotropic drugs);

• extrapyramidal disorders in organic brain diseases (myoclonus-epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment and prevention of extrapyramidal syndrome caused by the use of neuroleptics;

• epilepsy with retardation of mental processes and a decrease in cognitive productivity in conjunction with anticonvulsants;

• psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization;

• neurogenic disorders of urination (pollakiuria, urgency, urge incontinence).

Contraindications

• Hypersensitivity to the drug,

• acute severe kidney disease,

• pregnancy (1 trimester),

• phenylketonuria (syrup contains aspartame).

Method of administration and dosage

Pantogam syrup 100 mg / ml is taken orally 15-30 minutes after a meal. A single dose for adults is usually 2.5 - 10 ml (0.25 - 1 g), for children - 2.5 - 5 ml (0.25 - 0.5 g); the daily dose for adults is 15-30 ml (1.5-3 g), for children - 7.5-30 ml (0.75-3 g). The course of treatment is 1 - 4 months, sometimes up to 6 months. After 3 - 6 months, a second course of treatment is possible.

For children, depending on the age and pathology of the nervous system, the following dose range is recommended: children of the first year - 5 - 10 ml (0.5 - 1 g) per day, up to 3 years old - 5 - 12.5 ml (0.5 - 1.25 g) per day, for children from 3 to 7 years old - 7.5-15 ml (0.75 - 1.5 g), over 7 years old - 10 - 20 ml (1 - 2 g). The treatment tactics provides for increasing the dose within 7 to 12 days, taking the maximum dose for 15 to 40 days or more with a gradual decrease in the dose until it is canceled within 7 to 8 days. The course of treatment is 30 - 90 days (for certain diseases up to 6 months or more).

For schizophrenia in combination with psychotropic drugs - from 5 to 30 ml (0.5 to 3 g) per day. The course of therapy is from 1 to 3 months. For epilepsy, in combination with anticonvulsants - at a dose of 7.5 to 10 ml (0.75 - 1 g) per day. The course of therapy is up to 1 year or more. With neuroleptic syndrome, accompanied by extrapyramidal disorders, the daily dose is up to 30 ml (up to 3 g), treatment for several months. With extrapyramidal hyperkinesis in patients with organic diseases of the nervous system - from 5 to 30 ml (0.5 to 3 g) per day. The course of treatment is up to 4 months or more.

With the consequences of neuroinfections and traumatic brain injuries - from 5 to 30 ml (0.5 - 3 g) per day.

To restore working capacity at increased loads and asthenic conditions, Pantogam is prescribed 2.5 - 5 ml (0.25 - 0.5 g) 3 times a day.

For urination disorders for children - 2.5 - 5 ml (0.25 - 0.5 g), the daily dose is 25 - 50 mg / kg, the course of treatment is 1 - 3 months; adults - 5 - 10 ml (0.5 - 1 g) 2 - 3 times a day.

In conditions of long-term treatment, the simultaneous administration of the drug with other nootropic and stimulating agents is not recommended. Taking into account the nootropic effect of the drug, its administration is preferably carried out in the morning and afternoon hours.

Side effect

Allergic reactions are possible (rhinitis, conjunctivitis, allergic skin reactions). In this case, the drug is canceled. Very rarely, there are undesirable reactions from the central nervous system (hyperexcitation, sleep disturbance or drowsiness, lethargy, lethargy, headache, dizziness, noise in the head). In this case, the dose of the drug is reduced.

Overdose

Strengthening the symptoms of side effects (sleep disturbances or drowsiness, noise in the head). Treatment: activated carbon, gastric lavage, symptomatic therapy.

Interaction with other medicinal products

Prolongs the action of barbiturates, enhances the action of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, antipsychotics. The effect of pantogam is enhanced in combination with glycine, etidronic acid. Potentiates the action of local anesthetics (procaine).

Release form

Syrup 100 mg / ml. 100 ml in dark glass vials, sealed with lids with a control ring for the first opening. Each bottle together with a measuring spoon with a nominal volume of 5 ml with a line marked '%' (which corresponds to 2.5 ml) or a measuring spoon with a nominal volume of 5 ml with marks marked '%' and '%' (which corresponds to 1.25 ml and 2.5 ml), with instructions for use, are placed in a cardboard box.

Storage conditions

Store in a dark place at a temperature not exceeding 25 ? C. Store in the refrigerator for no more than 1 month after opening. Keep out of the reach of children.

Shelf life

2 years. Do not use after the expiration date. strong>

Conditions of dispensing from pharmacies.

On prescription.