Pangrol capsules, No. 20

Replacement therapy for insufficiency of exocrine pancreatic function in adults and children under the following conditions:

- chronic pancreatitis;

- cystic fibrosis;

- pancreas cancer;

- conditions after surgical interventions on the pancreas and stomach (complete or partial resection of the organ);

- after irradiation of the digestive tract, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy);

- Narrowing of the pancreatic duct, for example, due to a tumor or gallstones;

- Shwachman-Diamond syndrome;

- subacute pancreatitis;

- other diseases accompanied by exocrine pancreatic insufficiency.

Relative enzyme deficiency in the following conditions and situations:

- Gastrointestinal disorders of a functional nature, with acute intestinal infections, irritable bowel syndrome;

- the use of indigestible plant or fatty foods;

Preparation for X-ray and ultrasound examinations of the abdominal organs.

The dose of PangrolЃ 10000 is selected individually depending on the severity of the disease, as well as the volume and composition of food intake.

Unless otherwise indicated, adults are advised to take 2-4 capsules of PangrolЃ 10000 with each meal, swallowing the capsules whole (do not chew), drinking plenty of liquid (for example, a glass of water). If it is difficult for a patient to take a whole capsule (for example, in young children or elderly patients), you can pour its contents, for example, into a glass, opening the capsule by separating the cap from the body, and then take the contents (mini-tablets), drinking some liquid or added to liquid foods that do not require chewing (such as applesauce or fruit juice). Mixture of mini-tablets with food or liquid cannot be stored (take immediately after preparation).

An increase in the dose of the drug should be carried out only under the supervision of a physician, focusing on the dynamics of symptoms (for example, a decrease in steatorrhea, a decrease in abdominal pain).

It is not recommended to exceed the daily dose of enzymes, which is 15,000-20,000 lipase units / kg of body weight.

The duration of the course of treatment is set by the doctor and depends on the course of the disease.

For children, the dosage regimen and duration of treatment is set by the doctor depending on the severity of the disease and the composition of the food at the rate of 500 - 1000 lipase units / kg of the child's body weight for each meal.

Application for cystic fibrosis

The dose of PangrolЃ 10000 depends on body weight and should be 1000 lipase units / kg at the beginning of treatment for each meal for children under 4 years of age, and 500 lipase units / kg at each meal for children over 4 years of age.

The dose of the drug should be selected individually, depending on the severity of the disease, under the control of steatorrhea and support for an optimal diet. In most patients, the dose should be no more than 10,000 lipase units / kg of body weight per day or 4,000 lipase units / g of fat consumed.

Capsule contents (enteric-coated mini-tablets):

Core:

Active substance:

Pancreatin -153.5 mg

with minimal activity:

lipase 10,000 U of
amylase 9,000 U of
protease 500 U

Excipients: croscarmellose sodium - 5.12 mg, microcrystalline cellulose - 8.52 mg, hydrogenated castor oil - 1.709 mg, colloidal anhydrous silicon dioxide - 0.849 mg, magnesium stearate - 0.849 mg.

- acute pancreatitis;

- exacerbation of chronic pancreatitis;

- hypersensitivity to porcine pancreatin or other components of the drug.

Carefully

Pregnancy

There are no clinical data on the treatment of pregnant women with preparations containing pancreatic enzymes. In the course of studies on animals, absorption of enzymes of the pancreas of porcine origin was not detected, therefore, toxic effects on reproductive function and fetal development are not expected.