Panatus tablets 20mg, No. 10

Dry cough of any etiology (with colds, flu, whooping cough and other conditions).

Cough in the preoperative and postoperative period, during surgery, bronchoscopy.

butamirate citrate

pharmachologic effect

Antitussive agent of central action. Butamirate does not belong to the opium alkaloids. Suppresses cough by directly affecting the cough center. It has an expectorant, moderate bronchodilating and anti-inflammatory effect. Improves spirometry (reduces airway resistance) and blood oxygenation.

Pharmacokinetics

Quickly and completely absorbed when taken orally. With repeated use, its concentration in blood plasma remains linear and cumulation is not observed. In the blood, it undergoes hydrolysis to form 2-phenylbutyric acid and diethylaminoethoxyethanol. These metabolites also have antitussive activity. The binding of butamirate and its metabolites with plasma proteins is about 95%, this is due to their long T1 / 2 and long-term antitussive effect. Metabolites are excreted mainly by the kidneys, and acidic metabolites are largely associated with glucuronic acid. T1 / 2 - 6 h.

Side effect

From the side of the central nervous system: rarely - drowsiness, dizziness. From the digestive system: rarely - nausea, vomiting, diarrhea. From the side of the skin: rarely - exanthema. Others: development of allergic reactions is possible.

Drug interactions

Due to the fact that butamirate suppresses the cough reflex, the simultaneous use of expectorants should be avoided in order to avoid the accumulation of phlegm in the respiratory tract. During the period of treatment with butamirate, the use of drugs that have a depressing effect on the central nervous system (including hypnotics, antipsychotic, tranquilizers) is not recommended.