Otrivin spray nasal dosage. with menthol and eucalyptus 0.1% bottle 10ml
Category
Runny nose
Scope of the medicinal product
Ear, Throat, Nose
Release form
Spray
Manufacturer country
Switzerland
Package quantity, pcs
one
Release form, composition and packaging
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Dosed nasal spray (with menthol and eucalyptus) 0.1% in the form of a colorless opalescent solution with a characteristic smell of menthol and eucalyptus.
1 ml
xylometazoline hydrochloride 1 mg
sodium dihydrogen phosphate dihydrate - 2 mg, sodium hydrogen phosphate dodecahydrate - 2.8 mg, sodium chloride - 5 mg, benzalkonium chloride 50% solution - 0.1 mg (in terms of benzalkonium chloride - 0.05 mg), sorbitol 70% - 14 mg, disodium edetate - 0.5 mg, levomenthol (menthol) - 0.3 mg, cineole (eucalyptol) - 0.2 mg, macrogol glyceryl hydroxystearate - 2.5 mg, purified water - up to 1 ml.
10 ml - bottles made of high density polyethylene (1) with a pump dispensing device, a tip and a protective cap made of polyethylene - cardboard packs.
pharmachologic effect
A vasoconstrictor drug for topical use in ENT practice (decongestant). Xylometazoline has an alpha-adrenomimetic effect: it causes narrowing of the blood vessels of the nasal mucosa, eliminating edema and hyperemia of the nasopharyngeal mucosa. Xylometazoline also reduces concomitant mucus hypersecretion and facilitates drainage of blocked nasal passages and thus improves nasal breathing in case of nasal congestion. Otrivin® is well tolerated by patients with sensitive mucous membranes its effect does not prevent mucus separation. Otrivin® has a balanced pH value characteristic of the nasal cavity. The menthol and eucalyptol contained in the preparation have a cooling effect on the nasal mucosa, giving a feeling of freshness. In therapeutic concentrations, the drug does not irritate the mucous membrane,does not cause flushing. The effect occurs 2 minutes after application and lasts for 12 hours. In vitro studies have shown that xylometazoline in humans suppresses the infectious activity of the rhinovirus that causes the cold".
Pharmacokinetics
When applied topically in recommended doses, it is practically not absorbed, plasma concentrations are below the detection limit.
Indications for use
- acute respiratory diseases with symptoms of rhinitis
- acute allergic rhinitis
- hay fever
- sinusitis
- eustachitis
- otitis media (to reduce swelling of the nasopharyngeal mucosa)
- preparation of the patient for diagnostic manipulations in the nasal passages.
Contraindications for use
- hypersensitivity to xylometazoline and other components of the drug
- arterial hypertension
- tachycardia
- severe atherosclerosis
- glaucoma
- dry rhinitis or atrophic rhinitis
- hyperthyroidism
- condition after transsphenoidal hypophysectomy
- Surgical interventions on the meninges (in history)
- children under 12 years of age (nasal spray dosed 0.1%).
With care: diabetes mellitus
pheochromocytoma
cardiovascular diseases (including ischemic heart disease, angina pectoris)
hyperplasia of the prostate
with increased sensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.
Dosage regimen
Intranasally.
Adults and children over 12 years old: 1 injection in each nasal passage 3 times / day.
Should not be used more than 3 times / day.
It is recommended to apply one last time just before bedtime.
Overdose
Symptoms: Xylometazoline, when applied topically in an excessive dose or when taken accidentally, can cause severe dizziness, increased sweating, a sharp drop in body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and convulsions.
Following an increase in blood pressure, a sharp decrease can be observed.
Treatment: Appropriate supportive measures should be taken in case of any suspicion of an overdose, in some cases, immediate symptomatic treatment is indicated under medical supervision.
These measures should include
Name ENG
OTRIVIN
Clinical and pharmacological group
A vasoconstrictor drug for local use in ENT practice
ATX code
Xylometazoline
Dosage
0.1% x 10ml
Structure
1 ml contains: Active substance: xylometazoline hydrochloride 1 mg
Excipients: sodium dihydrogen phosphate dihydrate, sodium hydrogen phosphate dodecahydrate, sodium chloride, benzalkonium chloride (in the form of a 50% solution), sorbitol 70%, disodium edetate, levomenthol (menthol), cineol (eucalyptol), macrogol glyceryl hydroxyl purified
Indications
acute respiratory diseases with symptoms of rhinitis
acute allergic rhinitis
hay fever
sinusitis
eustachitis
otitis media (to reduce swelling of the nasopharyngeal mucosa)
preparation of the patient for diagnostic manipulations in the nasal passages. Contraindications for use - hypersensitivity to xylometazoline and other components of the drug
arterial hypertension
tachycardia
severe atherosclerosis
glaucoma
dry rhinitis or atrophic rhinitis
hyperthyroidism
condition after transsphenoidal hypophysectomy
surgical interventions on the meninges (in history)
children under 12 years of age (nasal spray dosed 0.1%).
With care: diabetes mellitus
pheochromocytoma
cardiovascular diseases (including ischemic heart disease, angina pectoris)
hyperplasia of the prostate
with increased sensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.
Storage conditions and periods
At a temperature not higher than 25 degrees.
Expiration date: 2.5 years
INN / Active ingredient
Xylometazoline
Specifications
Category
Runny nose
Scope of the medicinal product
Ear, Throat, Nose
Release form
Spray
Manufacturer country
Switzerland
Package quantity, pcs
one
Scope of application
Virology
Way of introduction
Through the respiratory tract
Vacation conditions
Without recipe
Volume, ml.
10 ml
Brand name
Otrivin
The amount of the dosage form in the primary package
10 ml
Primary packaging type
Bottle
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Decongestant - alpha adrenergic agonist
Anatomical and therapeutic characteristics
R01AA07 Xylometazoline
Dosage form
Dosed nasal spray [with menthol and eucalyptus]
Expiration date in days
912
Dosage (volume) of the substance in the preparation
0.001
Package weight, g
45
Mode of application
:
Intranasally.
Adults and children over 12 years old - 1 injection into each nasal passage 3 times a day.
Should not be used more than 3 times a day.
Information on technical characteristics, delivery set, country of manufacture "