Otrivin Express spray with menthol 0.05%, 10ml

• Symptomatic treatment of nasal congestion in acute respiratory diseases with symptoms of rhinitis (runny nose), acute allergic rhinitis, hay fever, sinusitis, eustachitis, otitis media (to reduce swelling of the nasopharyngeal mucosa).

• To facilitate the outflow of secretions in diseases of the paranasal sinuses.

• Preparing the patient for diagnostic manipulations in the nasal passages.

Internasally.

Adults and children over 12 years old: 1 injection into each nasal passage 1-2 times a day. Should not be used more than twice a day. Before first use, spray the nasal spray with several taps until the drug is evenly distributed.

1. Do not cut off the spray tip.

2. Thoroughly clean your nose.

3. Remove the protective cap. Hold the bottle vertically, supporting the bottom with your thumb, the nozzle between your middle and forefinger.

4. Direct the tip into the nasal passage by tilting the bottle forward slightly.

5. Press the nebulizing device while nebulizing the drug and inhale through the nose at the same time.

6. Repeat for the other nasal passage.

7. After use, clean and dry the tip before closing it with the protective cap. In the recommended dose, without consulting a doctor, use for no more than 7 days. Do not exceed the recommended dosage.

Nasal spray with menthol aroma is transparent or opalescent, from colorless to white, with the smell of menthol and eucalyptus.

1 ml oxymetazoline hydrochloride 0.5 mg

Excipients: sorbitol - 14 mg, sodium chloride - 5.5 mg, macrogol glycerol hydroxystearate - 2.5 mg, sodium dihydrogen phosphate dihydrate - 2 mg, levomenthol (menthol) - 0.3 mg, cineol (eucalyptol) - 0.2 mg, disodium edetate dihydrate - 0.5 mg, benzalkonium chloride 50% solution - 0.2 mg (in terms of benzalkonium chloride - 0.1 mg), sodium hydrogen phosphate dodecahydrate - 0.1 mg, purified water - up to 1 ml.

Hypersensitivity to the components of the drug, transphenoidal hypophysectomy and surgical interventions on the membranes of the brain (in history), angle-closure glaucoma, pregnancy, atrophic rhinitis, age up to 12 years.

Carefully:

Increased intraocular pressure, arterial hypertension, hyperthyroidism, diabetes mellitus, pheochromocytoma, porphyria, prostatic hyperplasia, diseases of the cardiovascular system. It is recommended to be careful when treating patients receiving MAO inhibitors at this time or having received them within the previous 2 weeks, tri- and tetracyclic antidepressants, as well as other drugs that increase blood pressure. If you have one of the listed diseases, be sure to consult your doctor before taking the drug.

Otrivin Express -spray is used for respiratory diseases with symptoms of rhinitis (runny nose):

Х Helps to fight nasal congestion due to the active ingredient - oxylometazoline.
Х Has a vasoconstrictor effect, reducing swelling of the mucous membrane of the nasopharynx.
Х Restores nasal breathing.
Х Relieves congestion in 25 seconds, maintaining the effect for up to 12 hours.

Pharmacodynamics

OtrivinЃ Express (oxymetazoline) is a sympathomimetic agent that acts on the alpha-adrenergic receptors of the nasal mucosa. It has a vasoconstrictor effect, reducing the swelling of the nasopharyngeal mucosa. When applied topically to the inflamed nasal mucosa, it reduces swelling and nasal discharge. Restores nasal breathing, eliminates swelling of the nasal mucosa, helps to restore aeration of the paranasal sinuses, middle ear cavity, which reduces the likelihood of bacterial complications (sinusitis, sinusitis, otitis media). With local intranasal application in therapeutic concentrations, oxymetazoline does not have a systemic effect, does not irritate and does not cause hyperemia of the nasal mucosa. The drug takes effect in 25 seconds,the duration of the action remains up to 12 hours.

Pharmacokinetics

With local intranasal administration, oxymetazoline does not have a systemic effect. The absorption of oxymetazoline is regarded as having no clinical significance.

Side effects

Nervous system disorders: Rarely: headache, insomnia, sedation, anxiety, irritability. Very rare: anxiety, drowsiness.

Gastrointestinal tract disorders: Rare: nausea.

Disturbances from the respiratory system, chest and mediastinal organs: Often: epistaxis, dryness of the nasal mucosa, discomfort from the nasal mucosa, sneezing. Uncommon: dry mouth, stomatitis, dry throat, sore throat.

Cardiac disorders: Rare: increased blood pressure, palpitations, tachycardia. Skin and subcutaneous tissue disorders: Rarely: exanthema, itching. General disorders and disorders at the injection site: Very rare: fatigue.

Allergic reactions: Rarely: systemic allergic reactions (angioedema of the tongue, throat, lips and face).

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not listed in the instructions, inform your doctor

Pregnancy and lactation

Otrivin Express is contraindicated during pregnancy due to the potential systemic vasoconstrictor effect. During breastfeeding, the drug should be used only after a careful assessment of the balance of benefits and risks for the mother and the fetus, it is not allowed to exceed the recommended dosage.

Drug interactions

OtrivinЃ Express is not recommended for patients receiving monoamine oxidase inhibitors at this time or who have received them within the previous 2 weeks. Concomitant use with tri- and tetracyclic antidepressants and sympathomimetic drugs can enhance the sympathomimetic effect of oxymetazoline.

Overdose

In case of oxymetazoline overdose, the clinical picture is characterized by: mydriasis, nausea, cyanosis, fever, tachycardia, cardiac arrhythmia, cardiac arrest, arterial hypertension, pulmonary edema, shortness of breath, mental disorders, hallucinations, convulsions. Symptoms associated with depression of the functions of the central nervous system may also appear, including Drowsiness, decreased body temperature, bradycardia, shock-like hypotension and loss of consciousness. Non-selective adrenergic antagonists such as phentolamine can be used to lower blood pressure. In severe cases, intubation and mechanical ventilation may be required. In case of moderate to severe overdose as a result of accidental oral ingestion, take activated charcoal and sodium sulfate (laxative).after a significant overdose, gastric lavage is prescribed. Conducting symptomatic therapy is shown. The use of vasopressors is contraindicated.