Otrivin Complex spray, 10ml

Special Price $17.48 Regular Price $28.00
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SKU
BIDL3181664
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Expiration Date: 05/2027

Russian Pharmacy name:

Отривин Комплекс спрей, 10мл

Otrivin Complex spray, 10ml

-Symptomatic treatment of edema and redness of the nasal cavity;

- acute respiratory diseases with symptoms of rhinitis (rhinitis), accompanied by congestion;

- acute allergic rhinitis;

-pollinosis;

-sinusitis.

Intranasally.

For patients over the age of 18 - 1 injection in each nasal passage 3 times a day. The drug is used for no more than 7 days without consulting a doctor. Long-term use of xylometazoline can cause swelling of the nasal mucosa and increased secretion, which is due to the development of increased sensitivity of cells to the active substances of the drug, the so-called. the opposite effect.

One injection of OtrivinЃ Complex contains about 70 mcg of xylometazoline hydrochloride and 84 mcg of ipratropium bromide.

Per 1 ml:
Active ingredients:
pratropium bromide monohydrate 0.6 mg, xylometazoline hydrochloride 0.5 mg.
Excipients: glycerol (85%) - 27.9 mg, disodium edetate dihydrate - 0.5 mg, concentrated hydrochloric acid - up to pH 4.5, sodium hydroxide - up to pH 4.5, water - up to 1 ml. '

-Hypersensitivity to the components of the drug;

-increased sensitivity to atropine or similar compounds (hyoscyamine, scopolamine);

-glaucoma;

-surgical interventions on the membranes of the brain (in history);

-pregnancy (I trimester);

-atrophic rhinitis;

- age up to 18 years.

With care: diabetes mellitus; hyperthyroidism; pheochromocytoma; angina pectoris III Ц IV functional class; obstruction of the bladder neck; hyperplasia of the prostate gland. It is recommended to be careful in the treatment of patients prone to nosebleeds, dizziness, tremors of skeletal muscles, sleep disturbances, arrhythmias, increased blood pressure, paralytic bowel obstruction and patients with cystic fibrosis.

If the patient has one of the listed diseases, it is imperative to consult a doctor before taking the drug.

Otrivin Complex is a complex remedy used for respiratory diseases with symptoms of rhinitis (rhinitis).
Contains 2 active components:
- Vasoconstrictor component - xylometazoline - reduces swelling and nasal congestion
- Anticholinergic component - ipratropium bromide - stops the flow from the nose.

Helps to fight immediately with 3 symptoms of a common cold:
- nasal congestion
- swelling of the mucous membrane
- flow from the nose
The drug begins to act in 5-10 minutes and has a lasting effect for 6-8 hours.

pharmachologic effect

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic action, it causes narrowing of the blood vessels of the nasal mucosa, thus eliminating edema and hyperemia of the nasopharyngeal mucosa. Relieves congestion by facilitating nasal breathing with rhinitis.

Ipratropium bromide has an anticholinergic effect. When administered intranasally, it reduces nasal secretion, stopping the flow from the nose by competitive inhibition of cholinergic receptors located in the epithelium of the nasal cavity.

In therapeutic concentrations, it does not irritate the mucous membrane, does not cause its hyperemia.

The drug begins to act in 5-10 minutes and has a lasting effect for 6-8 hours.

Pharmacokinetics

With intranasal administration, ipratropium bromide and xylometazoline hydrochloride are poorly absorbed and are present in blood plasma in small amounts.

Side effect

From the immune system: frequency unknown - hypersensitivity.

From the nervous system: often - taste disturbance, headache; infrequently - impaired sense of smell, dizziness, tremor; very rarely - insomnia.

From the side of the organ of vision: infrequently - eye irritation, dry eyes; the frequency is unknown - increased intraocular pressure, mydriasis, eye pain, photopsia, deterioration in closed-angle glaucoma, impaired clarity of visual perception, dilated pupil, halo effect (the presence of rainbow circles in the field of view around the light source).

Heart disorders: infrequently - palpitations, supraventricular tachycardia; very rarely - arrhythmic pulse; frequency unknown - atrial fibrillation.

From the respiratory system: very often - nosebleeds, irritation and / or dryness of the nasopharyngeal mucosa; often - a burning sensation, tingling sensation, sneezing, nasal hypersecretion; nasal congestion (with frequent and / or prolonged use of the drug), dry throat, sore throat, rhinalgia; infrequently - nasal ulcer, sneezing, throat pain, cough, dysphonia; rarely - a runny nose; the frequency is unknown - discomfort in the paranasal sinuses, spasm of the larynx, swelling of the pharynx.

From the digestive system: often - dry mouth; infrequently - dyspepsia, nausea; frequency unknown - difficulty swallowing.

On the part of the skin and subcutaneous tissues: the frequency is unknown - itching, skin rash, urticaria.

From the urinary system: the frequency is unknown - difficulty urinating.

General reactions: infrequently - discomfort, fatigue; frequency unknown - chest discomfort, thirst.

Allergic reactions: rarely - systemic allergic reactions (anaphylactic reaction, angioedema of the tongue, lips and face, laryngospasm).

If any of the above side effects are aggravated, or the patient has noticed any other side effects, he should inform the doctor about it.

Application during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Application in children

The use is contraindicated under the age of 18 years.

Use in elderly patients

The experience of using the drug in patients over 70 years of age is limited.

special instructions

Before use, you must clean the nasal passages. Should not be used for a long time, for example, in chronic rhinitis.

Do not allow the drug to come into contact with or around the eyes. In case of contact, temporary blurred vision, irritation, pain, redness of the eyes may occur, and an exacerbation of angle-closure glaucoma may develop. If the drug gets into your eyes, rinse your eyes with copious amounts of cold water and consult a doctor if you have eye pain or blurred vision.

Influence on the ability to drive vehicles and mechanisms

When using OtrivinЃ Complex, there have been cases of visual impairment (including blurred vision and dilated pupil), dizziness and fatigue. Patients should be warned that when such symptoms appear, they should refrain from driving vehicles, operating mechanisms, and also from performing actions in which such symptoms may entail a risk to the patients themselves and to other people.

Overdose

With nasal administration of OtrivinЃ Complex, an acute overdose is unlikely, because absorption of the drug is extremely insignificant.

Symptoms: in case of an overdose of xylometazoline, the clinical picture is characterized by nausea, sweating, a decrease in body temperature, headache, bradycardia, impaired accommodation, arterial hypertension, respiratory depression, coma. Arterial hypertension can be replaced by hypotension.

With excessive use of ipratropium bromide, an overdose is unlikely due to the extremely insignificant absorption of the substance into the blood, but dry mouth, difficulty in accommodation, and tachycardia may develop.

A significant overdose can cause symptoms associated with the cholinolytic effect of the drug on the part of the central nervous system, including hallucinations, for the elimination of which cholinesterase inhibitors are prescribed.

Treatment: Appropriate supportive measures should be taken in case of any suspicion of an overdose, if necessary, immediate symptomatic treatment is indicated under the supervision of a physician. Symptomatic therapy must be carried out under the supervision of a physician. These measures should include monitoring the patient for 6 hours. In the case of severe poisoning with cardiac arrest, resuscitation should continue for at least 1 hour.

Drug interactions

The drug is incompatible with the simultaneous administration of MAO inhibitors, tri- and tetracyclic antidepressants, as well as in the case of taking these drugs within the previous 2 weeks.

Sympathomimetic drugs cause the release of catecholamines, incl. norepinephrine, which has a vasoconstrictor effect, resulting in an increase in blood pressure. With a significant increase in blood pressure, treatment with OtrivinЃ Complex should be canceled, symptomatic treatment should be carried out.

The use with tri- and tetracyclic antidepressants can enhance the sympathomimetic effect of xylometazoline.

With the concomitant administration of other drugs with anticholinergic activity, it is possible to enhance the anticholinergic effect of ipratropium bromide.

The above interaction was studied individually for both active substances that make up OtrivinЃ Complex. In combination for both active substances, the above interaction has not been studied.

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