Otolorin drops, 10ml

The drug is used topically by instillation into the external auditory canal.

In order to avoid the discomfort associated with the ingress of cold liquid into the ear canal, it is recommended to warm the bottle by holding it in your hand before using the ear drops. Adults are prescribed 2-3 drops 2-3 times / day; children - 1-2 drops 2-3 times / day. A tampon moistened with a solution can be placed in the external auditory canal.

The duration of the course of therapy is no more than 7 days. Drops should be instilled into the patient lying on the side so that the affected ear is on top. After the procedure, the patient must remain in this position for several minutes.

Ear drops in the form of a transparent, colorless or slightly colored liquid with a characteristic odor.

1 ml

procaine hydrochloride 20 mg

boric acid 30 mg

Excipients: 0.1M sodium hydroxide solution - up to pH 4.5-6.0, ethyl alcohol 70% - up to 1 ml.

• Violation of the integrity of the tympanic membrane,

• chronic renal failure,

• pregnancy,

• lactation period,

• children's age up to 1 year,

• hypersensitivity to drug components

pharmachologic effect

Combined preparation for topical use, has an antiseptic, disinfectant and local anesthetic effect.

Boric acid has an antiseptic, fungistatic effect. Has a mild irritant effect on granulation tissue.

Procaine is a local anesthetic with moderate anesthetic activity and a wide range of therapeutic effects. Being a weak base, it blocks sodium channels, prevents the generation of impulses at the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses the conduction of not only painful, but also impulses of a different modality.

Pharmacokinetics

Boric acid is absorbed through damaged skin, wound surfaces, and mucous membranes. In young children, it penetrates especially well through the skin and mucous membranes (deaths have been described when accidentally ingested or applied to damaged skin). It is excreted slowly (cumulates with repeated administration). About 50% is excreted in the urine within 12 hours, the remainder within 5-7 days.

Procaine undergoes complete systemic absorption. The degree of absorption depends on the site and route of administration (especially on vascularization and blood flow rate in the area of ??administration) and the final dose (amount and concentration). It is rapidly hydrolyzed by plasma and liver esterases to form two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating effect) and para-aminobenzoic acid (PABA) (is a competitive antagonist of sulfanilamide chemotherapeutic drugs and can weaken their antimicrobial effect). T1 / 2 30-50 s, in the neonatal period - 54-114 s. It is excreted mainly by the kidneys in the form of metabolites, no more than 2% is excreted unchanged.

Side effect

Systemic reactions: possibly - allergic reactions (skin rash, desquamation of the epithelium, confusion, convulsions, oliguria, rarely - anaphylactic shock); with prolonged use, headache, nausea, vomiting, diarrhea may occur.

Local reactions: itching, burning, which disappear on their own in 1-2 minutes and do not require discontinuation of the drug.

Toxic reactions when used with a perforated eardrum: nausea, vomiting, skin redness, itching, urticaria, edema, deafness, imbalance, confusion.

Application during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Application for impaired renal function

The use of the drug is contraindicated in chronic renal failure.

Application in children

The use of the drug in children under 1 year of age is contraindicated.

special instructions

Avoid contact with mucous membranes.

Before using the drug, you must make sure the integrity of the tympanic membrane. If used with a perforated eardrum, the drug may cause toxic reactions.

Influence on the ability to drive vehicles and mechanisms

During the period of drug treatment, care should be taken when performing potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Drug interactions

The metabolite of procaine (para-aminobenzoic acid) is an antagonist of sulfonamides, therefore, it is possible to reduce the antimicrobial effect of sulfanilamide drugs in the case of simultaneous use with the drug.