Otinum drops 20%, 10g

• For symptomatic relief of ear pain in acute otitis media, chronic otitis media, otitis externa, myringitis.

• Softening hardened earwax before removing it from the ear.

For acute and chronic otitis media, myringitis and otitis externa

It is instilled into the external auditory canal 3-4 drops 3-4 times a day.

The course of treatment should be no more than 3 days.

For softening 'sulfur plugs' before removing them

3-4 drops are instilled into the external auditory canal twice a day for 4 days.

Before using the ear drops, it is recommended to warm the bottle by holding it in your hand to avoid the discomfort associated with the ingress of cold liquid into the ear.

Drops should be instilled in a patient lying on his side so that his ear is directed upwards. After the procedure, the patient should remain in the same position for several minutes.

There is no need to change the dosage regimen for the elderly, children and patients with impaired liver and kidney function.

If after treatment there is no improvement or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the route of administration and the doses indicated in the instructions for use.

Spray for topical application, dosed in the form of a clear solution of yellow-green color, with a peppermint aroma.

1 dose

benzydamine hydrochloride 0.255 mg

Excipients: methyl parahydroxybenzoate - 0.17 mg, ethanol 96% - 17 mg, glycerol (glycerin) - 8.5 mg, peppermint flavor 27198/14 - 0.17 mg, sodium saccharinate - 0.0408 mg, polysorbate 60 - 0.0085 mg, sodium bicarbonate - 0.0034 mg , dye quinoline yellow 70 (E104) - 0.0034 mg, indigotine dye 85% (E132) - 0.00017 mg, purified water - up to 170 ?l.

- Hypersensitivity to choline salicylate or other components of the drug.

-Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history).

- Violation of the integrity of the tympanic membrane.

-Pregnancy and breastfeeding period (due to lack of data).

-Children under 1 year old.

Carefully

Allergic ('hay') rhinitis, polyps of the mucous membrane of the nasal passages.

Pharmacological properties

Pharmacodynamics

Choline salicylate is a derivative of salicylic acid, when instilled into the ear, it has an anti-inflammatory and analgesic effect. The action of choline salicylate is based on inhibition of the activity of cyclooxygenase, an enzyme responsible for the synthesis of prostaglandins. Choline salicylate also inhibits the synthesis of thromboxane and prostacyclin.

It also has antimicrobial and antifungal effects (in acidic and alkaline environments).

When applied topically, it does not have a systemic effect.

Pharmacokinetics

There are no data on the pharmacokinetics of choline salicylate when instilled into the ear.

Side effect

The frequency of development has not been established.

Local hypersensitivity reactions: itching, skin redness.

Ear diseases: the use of the drug in patients with perforation of the eardrum can lead to hearing impairment.

If you have any side effects indicated in the instructions, or they are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor.

Overdose

An overdose of the drug when instilled into the ear is impossible.

One bottle of the drug contains 2 grams of choline salicylate. If accidentally swallowed, this amount of the drug can only be dangerous to newborns.

Symptoms

Symptoms that may occur if an overdose is swallowed include confusion, dizziness, increased sweating, vomiting, tinnitus, and hyperventilation. After swallowing very large amounts of the drug, symptoms of CNS depression such as drowsiness, lethargy, convulsions, and coma may appear.

Treatment

Oral overdose relief:

- removal of choline salicylate from the body (induce vomiting, wash out the stomach, take activated charcoal);

- monitoring the patient's condition (first of all - water and electrolyte balance);

- symptomatic treatment (including correction of water and electrolyte balance; in cases where the concentration of salicylate exceeds 300 mg per liter - forced diuresis).

Interaction with other medicinal products

There are no data indicating the interaction of choline salicylate with other drugs when instilled in the ear.

special instructions

In children under 1 year of age, the drug can only be used under close medical supervision.

Salicylic acid derivatives can cause hearing impairment or deafness if they enter the middle ear through a damaged eardrum. In this regard, the drug should not be used without a preliminary examination by an otorhinolaryngologist and without a doctor's instructions.

The effect of the drug on the ability to drive vehicles, mechanisms

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.