Okupres-E eye drops 0.5%, 5 ml

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Expiration Date: 11/2025

Russian Pharmacy name:

Окупрес-Е капли глазные 0,5%, 5 мл

Okupres-E eye drops 0.5%, 5 ml

Glaucoma (open-angle, chronic, aphakic, secondary).

Conjunctival. The recommended starting dose is 1 drop of 0.25% solution 2 times / day. If the reaction is insufficient, use a 0.5% solution. With stabilization of intraocular pressure - 1 time / day.

Eye drops 0.5% in the form of a transparent, colorless or light yellow solution.

1 ml

timolol (in the form of maleate) 5 mg

  • Bronchial asthma,

  • chronic obstructive pulmonary disease,

  • sinus bradycardia,

  • AV blockade of I and II degrees,

  • severe heart failure

  • cardiogenic shock,

  • severe rhinitis

  • severe dystrophic diseases of the cornea.

pharmachologic effect

Non-selective beta-blocker. When applied topically in ophthalmology, it reduces both normal and increased intraocular pressure by reducing the formation of intraocular fluid and improving its outflow, does not affect accommodation and pupil size.

It has antianginal, hypotensive and antiarrhythmic effects, which are manifested with systemic use. Reduces the automatism of the sinus node, reduces heart rate, slows down AV conduction, reduces contractility and myocardial oxygen demand.


When applied topically, it quickly penetrates the cornea, in a small amount enters the systemic circulation due to absorption through the vessels of the conjunctiva, the mucous membranes of the nose and lacrimal tract.

Side effect

From the side of the organ of vision: when applied topically, irritation and hyperemia of the conjunctiva, skin of the eyelids, burning and itching in the eyes, lacrimation, photophobia, edema of the corneal epithelium, punctate superficial keratopathy, corneal hypesthesia, diplopia, ptosis, dry eyes are possible. During fistulizing antiglaucoma operations, retinal detachment may develop in the postoperative period.

With systemic use, heart failure, bradycardia, AV blockade, arterial hypotension are possible; headache, sleep disturbances, nightmares, asthenia, agitation, depression, paresthesia and cold extremities; nausea, vomiting, diarrhea; shortness of breath, bronchospasm; muscle weakness; allergic skin reactions, exacerbation of psoriasis, dryness of the conjunctiva.

Application during pregnancy and lactation

The safety and efficacy of use during pregnancy have not been studied.

Application for violations of liver function

Use with caution in patients with impaired liver function.

Application for impaired renal function

Use with caution in patients with impaired renal function.

Application in children

The safety and effectiveness of use in children has not been studied.

special instructions

Use with caution in patients with impaired liver function, kidney function, diabetes mellitus (especially labile course). With prolonged use, it increases the level of triglycerides in the blood plasma.

The safety and efficacy of use in children has not been studied.

In ophthalmology, it is used for a long time, therefore, during the treatment period, an examination of the cornea should be carried out at least once every 6 months, the function of lacrimation and the state of the visual fields should be monitored.

Influence on the ability to drive vehicles and mechanisms

During the period of treatment, one should refrain from engaging in potentially hazardous activities that require increased attention, rapid psychomotor reactions.

When used in ophthalmology immediately after instillation, it is possible to reduce visual acuity and slow down psychomotor reactions, therefore, you should refrain from engaging in potentially hazardous activities that require increased attention for 30 minutes.

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