Oki rinse solution 16mg / ml, 150ml

Symptomatic treatment of inflammatory diseases of ENT organs and oral cavity:

• angina;

• laryngitis;

• pharyngitis;

• tonsillitis;

• stomatitis;

• gingivitis;

• glossitis;

• aphthae;

• paradontopathy;

• chronic periodontal disease;

• dental manipulations (as an analgesic).

Two rinses a day, 10 ml of solution at a time. 10 ml of solution should be measured using a measuring cup included in the package, diluted in 100 ml (half a glass) of drinking water. To open the bottle, press the cap on the top and turn it counterclockwise. arrows. After use, screw the cap back on tightly. Accidental swallowing of the solution does not lead to serious consequences. a single dose for rinsing contains 160 mg of ketoprofen lysine, which corresponds to the dose intended for oral administration.

Topical solution

1 ml

ketoprofen lysine salt 16 mg

excipients: glycerol - 200 mg; ethanol - 0.05 ml; methyl p-hydroxybenzoate - 1.5 mg; mint flavor - 3 mg; menthol - 0.7 mg; sodium saccharin - 2 mg; Verde chertoza (brilliant green) - 0.16 mg; sodium hydrogen phosphate - 0.022 g; purified water - 1 ml

• Hypersensitivity to ketoprofen and other components of the drug, acetylsalicylic acid or other NSAIDs,

• complete or incomplete combination of bronchial asthma,

• recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including a history),

• children's age (up to 12 years old).

  Carefully

• Erosive and ulcerative lesions of the gastrointestinal tract (exacerbation), Crohn's disease, diverticulitis, peptic ulcer, hemophilia and other bleeding disorders, chronic heart failure, bronchial asthma, old age, pregnancy (I and II trimester).

pharmachologic effect

NSAIDs. It has an analgesic, anti-inflammatory and anti-edema effect. Inhibits the activity of COX, which leads to inhibition of the synthesis of prostaglandins. In addition, ketoprofen inhibits lipoxygenase, bradykinin synthesis, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process.

Ketoprofen does not adversely affect the condition of the articular cartilage.

Pharmacokinetics

Ketoprofen is absorbed very slowly and practically does not accumulate in the body. Bioavailability is 5%. Ketoprofen penetrates into the subcutaneous tissue, ligaments and muscles, synovial fluid and reaches therapeutic concentrations there. The concentration of the drug in the blood plasma is extremely low. Ketoprofen is metabolized in the liver to form conjugates, which are mainly excreted in the urine. Ketoprofen is characterized by slow excretion in the urine.

Side effect

Allergic reactions: very rarely - angioedema, anaphylaxis.

On the part of the skin and subcutaneous fat: infrequently - erythema, itching, burning, eczema, mild transient dermatitis; rarely - urticaria, rash, photosensitivity, bullous dermatitis, purpura, erythema multiforme, lichenoid dermatitis, skin necrosis, Stevens-Johnson syndrome; very rarely - a single case of severe contact dermatitis (against the background of poor hygiene and insolation), a single case of severe generalized photodermatitis, toxic epidermal necrolysis.

From the respiratory system: very rarely - asthmatic attacks (as a variant of an allergic reaction).

From the urinary system: very rarely - deterioration of renal function in patients with chronic renal failure.

Application during pregnancy and lactation

Contraindicated for use in the third trimester of pregnancy. Application in the I and II trimesters is possible in cases where the expected benefit of therapy to the mother outweighs the potential risk to the fetus.

Application during lactation (breastfeeding) is not recommended.

Application for violations of liver function

It should be used with caution in case of impaired liver function.

Application for impaired renal function

It should be used with caution in case of impaired renal function.

Application in children

Contraindication: children under 15 years of age.

Use in elderly patients

Use with caution in elderly patients.

special instructions

Avoid contact with the eyes, skin around the eyes, mucous membranes.

Ketoprofen can be used externally in combination with oral administration. The total daily dose, regardless of the dosage form, should not exceed 200 mg.

To reduce the risk of developing photosensitivity, it is recommended to protect the areas of skin treated with ketoprofen with clothing from UV exposure throughout the treatment period and for another 2 weeks after stopping the use of the gel.

Do not use as an occlusive dressing.

Drug interactions

Since the concentration of ketoprofen in the blood plasma is extremely low, symptoms of interaction with other drugs (similar symptoms with systemic use) are possible only with frequent and prolonged use.

The simultaneous use of other external agents containing ketoprofen or other NSAIDs is not recommended.

The simultaneous administration of acetylsalicylic acid reduces the degree of binding of ketoprofen to blood plasma proteins.

Ketoprofen reduces the excretion of methotrexate and increases its toxicity.

Patients taking coumarin-containing anticoagulants are advised to undergo treatment under the supervision of a physician.