Nykotynovaya acid | Nicotinic acid-SOLOpharm injection for 10 mg / ml 1 ml ampoules 10 pcs.
Special Price
$14.55
Regular Price
$22.00
In stock
SKU
BID608275
Product form
Injection
Injection
Product form
Injection
Pharmacological action
Pharmacodynamics
Nicotinic acid - a water-soluble vitamin of group B, replenishes the deficiency of vitamin PP (vitamin B3), is a specific anti-pellagric drug (vitamin PP vitamin deficiency).
Has a vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect, activates the fibrinolysis system. It has antiatherogenic properties.
Pharmacokinetics
When administered parenterally, it is rapidly distributed in body tissues. It accumulates mainly in the liver, as well as in adipose tissue and in the kidneys. In the liver, nicotinic acid is converted into an amine, which is integrated into nicotinamide adenine dinucleotide (NAD), which is a prosthetic group of enzymes that transfer hydrogen and carry out redox processes.
The main metabolites are N-methyl-2-pyridone-3-carboxamide and N-methyl-2-pyridone-5-carboxamide, which do not have pharmacological activity. It can be synthesized in the intestines by bacterial flora from tryptophan taken from food (from 60 mg of tryptophan 1 mg of nicotinic acid is formed) with the participation of pyridoxine (vitamin B6) and riboflavin (vitamin B2).
The elimination half-life is 45 minutes. It is excreted from the body by the kidneys in an unchanged form and in the form of metabolites, when taking high doses - mainly in an unchanged form. Renal clearance depends on the level of nicotinic acid in blood plasma and may decrease with a high concentration in plasma.
Indications
Avitaminosis PP (pellagra). Combined therapy: ischemic stroke, obliterating vascular disease of the extremities (obliterating endarteritis, Raynaud's disease), facial neuritis.
Hartnup disease (a hereditary disease accompanied by impaired absorption of certain amino acids, including tryptophan).
Use during pregnancy and lactation
Taking into account the injection route of administration of the drug, its side effects, use during pregnancy strictly as prescribed by the doctor, if the expected effect of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to use the drug during lactation, breast-feeding should be discontinued.
Special instructions
During treatment, liver function should be regularly monitored.
With prolonged use of nicotinic acid in high doses, fatty liver infection may develop.
To prevent hepatotoxicity, it is necessary to include methionine-rich foods (cottage cheese) in the diet, or methionine or other lipotropic drugs.
Dosage and administration
The drug is administered subcutaneously, intramuscularly, intravenously (slowly).
With pellagra (vitamin deficiency PP), 1 ml of a 1% (10 mg) solution is administered parenterally 1-2 times a day for 10-15 days.
Side effects of
From the cardiovascular system: sensation of a ԲushԠof blood to the scalp, hyperemia of the face and upper body with a sensation of tingling and burning sensation, with rapid administration, a decrease in blood pressure, orthostatic hypotension, collapse.
From the central nervous system and peripheral nervous system: paresthesia, dizziness.
From the digestive system: with prolonged use - fatty liver.
From the side of metabolism: with prolonged use - hyperuricemia, decreased glucose tolerance, increased blood levels of aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase.
Local reactions: soreness at the site of subcutaneous and intramuscular injection.
Other: allergic reactions (skin rash, pruritus, stridor respiration).
Drug Interactions
Caution must be exercised when combined with antihypertensive agents, anticoagulants, and acetylsalicylic acid.
Nicotinic acid reduces the toxicity of neomycin and prevents its decrease in the concentration of cholesterol and high density lipoproteins.
When used together with sulfonyl urea, it can increase blood glucose.
When administered with lovastatin increases the risk of developing myopathy.
Overdose
An overdose is unlikely due to the low toxicity of the drug.
Nicotinic acid in individuals with individual intolerance can cause redness of the face and upper half of the body, dizziness, flushing of the head, hives, paresthesias (numbness, loss of sensation, tingling, crawling).
Treatment: symptomatic.
Storage conditions
Store at a temperature not exceeding 25 РC.
Keep out of the reach of children.
Term hodnosty
5 years
Deystvuyuschee substances
Nykotynovaya acid
Pharmacy leave conditions
Prescription
Grotex Ltd. LLC, Russia
Injection
Pharmacological action
Pharmacodynamics
Nicotinic acid - a water-soluble vitamin of group B, replenishes the deficiency of vitamin PP (vitamin B3), is a specific anti-pellagric drug (vitamin PP vitamin deficiency).
Has a vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect, activates the fibrinolysis system. It has antiatherogenic properties.
Pharmacokinetics
When administered parenterally, it is rapidly distributed in body tissues. It accumulates mainly in the liver, as well as in adipose tissue and in the kidneys. In the liver, nicotinic acid is converted into an amine, which is integrated into nicotinamide adenine dinucleotide (NAD), which is a prosthetic group of enzymes that transfer hydrogen and carry out redox processes.
The main metabolites are N-methyl-2-pyridone-3-carboxamide and N-methyl-2-pyridone-5-carboxamide, which do not have pharmacological activity. It can be synthesized in the intestines by bacterial flora from tryptophan taken from food (from 60 mg of tryptophan 1 mg of nicotinic acid is formed) with the participation of pyridoxine (vitamin B6) and riboflavin (vitamin B2).
The elimination half-life is 45 minutes. It is excreted from the body by the kidneys in an unchanged form and in the form of metabolites, when taking high doses - mainly in an unchanged form. Renal clearance depends on the level of nicotinic acid in blood plasma and may decrease with a high concentration in plasma.
Indications
Avitaminosis PP (pellagra). Combined therapy: ischemic stroke, obliterating vascular disease of the extremities (obliterating endarteritis, Raynaud's disease), facial neuritis.
Hartnup disease (a hereditary disease accompanied by impaired absorption of certain amino acids, including tryptophan).
Use during pregnancy and lactation
Taking into account the injection route of administration of the drug, its side effects, use during pregnancy strictly as prescribed by the doctor, if the expected effect of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to use the drug during lactation, breast-feeding should be discontinued.
Special instructions
During treatment, liver function should be regularly monitored.
With prolonged use of nicotinic acid in high doses, fatty liver infection may develop.
To prevent hepatotoxicity, it is necessary to include methionine-rich foods (cottage cheese) in the diet, or methionine or other lipotropic drugs.
Dosage and administration
The drug is administered subcutaneously, intramuscularly, intravenously (slowly).
With pellagra (vitamin deficiency PP), 1 ml of a 1% (10 mg) solution is administered parenterally 1-2 times a day for 10-15 days.
Side effects of
From the cardiovascular system: sensation of a ԲushԠof blood to the scalp, hyperemia of the face and upper body with a sensation of tingling and burning sensation, with rapid administration, a decrease in blood pressure, orthostatic hypotension, collapse.
From the central nervous system and peripheral nervous system: paresthesia, dizziness.
From the digestive system: with prolonged use - fatty liver.
From the side of metabolism: with prolonged use - hyperuricemia, decreased glucose tolerance, increased blood levels of aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase.
Local reactions: soreness at the site of subcutaneous and intramuscular injection.
Other: allergic reactions (skin rash, pruritus, stridor respiration).
Drug Interactions
Caution must be exercised when combined with antihypertensive agents, anticoagulants, and acetylsalicylic acid.
Nicotinic acid reduces the toxicity of neomycin and prevents its decrease in the concentration of cholesterol and high density lipoproteins.
When used together with sulfonyl urea, it can increase blood glucose.
When administered with lovastatin increases the risk of developing myopathy.
Overdose
An overdose is unlikely due to the low toxicity of the drug.
Nicotinic acid in individuals with individual intolerance can cause redness of the face and upper half of the body, dizziness, flushing of the head, hives, paresthesias (numbness, loss of sensation, tingling, crawling).
Treatment: symptomatic.
Storage conditions
Store at a temperature not exceeding 25 РC.
Keep out of the reach of children.
Term hodnosty
5 years
Deystvuyuschee substances
Nykotynovaya acid
Pharmacy leave conditions
Prescription
Grotex Ltd. LLC, Russia
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