Nyfuratel | Macmiror tablets coated. about 200 mg of 20 pieces.

Release form

Tablets

Packing

20 pcs.

Pharmacological action

Macmirror - antimicrobial, antiprotozoal, antifungal.

Pharmacodynamics

Nifuratel, an antimicrobial agent from the group of nitrofurans, has an antiprotozoal, antifungal and antibacterial effect.

Nifuratel has high efficiency and low toxicity, which leads to a wide range of its clinical applications.

Highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms: at a minimum inhibitory concentration (MIC) of 12.5–25 μg / ml inhibits from 44.3 to 93.2% of the cultures.

It is highly active against both aerobic and anaerobic pathogens.

The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhid, Salmonella spp. ., Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., Other atypical enterobacteria, as well as protozoa (amoeba, giardia) less active against Proteus mirabgar, Proteud vulse aeruginosa.

Is the drug of choice for the treatment of salmonellosis, shigellosis and other intestinal bacterial infections.

Active against Trichomonas vaginalis, highly active against fungi of the genus Candida.

Particularly effective against metronidazole resistant Helicobacter pylori strains.

Data showing high activity of nifuratel (in vitro and in vivo) against Atopobium vaginae, the main marker of bacterial vaginosis, has been obtained.

Pharmacokinetics

When administered orally, it is rapidly absorbed from the digestive tract. Penetrates through the BBB and the hematoplacental barrier, excreted in breast milk. Metabolized in the liver and muscle tissue. It is completely excreted from the body by the kidneys (30-50% - unchanged), having a strong antibacterial effect in the urinary tract.

Contraindications

Hypersensitivity. With caution - pregnancy, lactation.

Use during pregnancy and lactation

Nifuratel crosses the hematoplacental barrier after an overdose, therefore, the use of the drug is possible only under strict indications, if the expected effect of therapy exceeds the potential risk to the fetus.

Nifuratel is excreted in breast milk, so if you need to prescribe the drug during lactation, you should decide whether to stop breastfeeding.

Special instructions

When monotherapy of vaginal infections with Macmiror is recommended, it is recommended to increase the daily dosage to 4-6 tablets. During treatment should refrain from sexual intercourse.

Influence on the ability to drive a car or other mechanisms: no adverse effects were detected.

Composition

1 tablet contains:

Active substance: nifuratel 200 mg.

Auxiliary Ingredients: starch polyethylene glycol 6000 talc magnesium stearate gelatine gum arabic sucrose magnesium carbonate titanium dioxide E wax.

Side effects

Dyspeptic disorders: nausea, vomiting, bitterness in the mouth, diarrhea, heartburn, gastralgia.

Allergic reactions: skin rash, itching.

Drug Interactions

Enhances the antifungal effect of nystatin.

Storage conditions

In a dry place, at a temperature not exceeding 25 РC

Expiration

2 years.

active substance

nifuratel

Terms leave through pharmacies

In retseptu

lekarstvennaja form

tablets

Prescription

Adults prescribed by a doctor, Children prescribed by a doctor

Indications

Indications

vaginitis, an inflammation of female genitals, vaginal candidiasis, from amebiasis and giardiasis

Doppely Farmatseutitsi, Italy