Nurofen (from 6 years old) tab. p / o 200mg # 8

Release form, composition and packaging

?

Film-coated tablets (for children from 6 years old), white or almost white, round, biconvex, with a black print Nurofen" on one side

on a cross-section of a tablet, the core is white or almost white, the shell is white or almost white.

1 tab.

ibuprofen 200 mg

croscarmellose sodium - 30 mg, sodium lauryl sulfate - 0.5 mg, sodium citrate dihydrate - 43.5 mg, stearic acid - 2 mg, colloidal silicon dioxide - 1 mg.

Shell composition: sodium carmellose - 0.7 mg, talc - 33 mg, acacia gum - 0.6 mg, sucrose - 116.1 mg, titanium dioxide - 1.4 mg, macrogol 6000 - 0.2 mg, black ink [Opakod S-1-277001] (shellac - 28.225%, iron dye black oxide (E172) - 24.65%, propylene glycol - 1.3%, isopropanol * - 0.55%, butanol * - 9.75%, ethanol * - 32.275%, purified water * - 3.25%).

* solvents evaporated after the printing process.

8 pcs.

- blisters (1) - cardboard packs.

pharmachologic effect

NSAIDs.

Has a fast directed action against pain (analgesic), antipyretic and anti-inflammatory action.

The mechanism of action of ibuprofen, a propionic acid derivative, is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.

Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of prostaglandins.

In addition, ibuprofen reversibly inhibits platelet aggregation.

The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics

Absorption and distribution Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract. After taking the drug on an empty stomach, Cmax of ibuprofen in blood plasma is reached after 45 minutes. Taking the drug with food can increase the time to reach Cmax up to 1-2 hours. Plasma protein binding is 90%. It slowly penetrates into the joint cavity, remains in the synovial fluid, creating higher concentrations in it than in the blood plasma. In the cerebrospinal fluid, lower concentrations of ibuprofen are found in comparison with blood plasma. In limited studies, ibuprofen has been found in breast milk at very low concentrations. Metabolism and excretion After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver.It is excreted by the kidneys (unchanged - no more than 1%) and, to a lesser extent, with bile. T1 / 2 - 2 hours

Indications for use

- headache

- migraine

- toothache

- neuralgia

- myalgia

- back pain

- rheumatic pains

- joint pain

- algodismenorrhea

- fever with flu and ARVI.

Contraindications for use

- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including history) - erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or bleeding ulcer) - a history of bleeding or perforation of gastrointestinal ulcers, provoked by the use of NSAIDs - severe liver failure or liver disease in the active phase - renal failure of severe severity (CC < 30 ml / min) - confirmed hyperkalemia - severe heart failure (NYHA class IV) - decompensated heart failure - the period after coronary artery bypass grafting - cerebrovascular or other bleeding - hemophilia and other blood clotting disorders (including hypocoagulation) - hemorrhagic diathesis - III trimester of pregnancy - children under 6 years old - fructose intolerance,

Dosage

200mg

Structure

The content of ibuprofen in one tablet is 200 mg.

Does not contain sugar.

Does not contain dyes.

Indications

Nurofen is used for headache and toothache, migraine, painful periods, neuralgia, back pain, muscle and rheumatic pain

and also in case of fever with flu and colds.

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract and the exacerbation phase, including gastric ulcer and 12 duodenal ulcer in the exacerbation stage, ulcerative colitis, peptic ulcer, Crohn's disease

heart failure

severe course of arterial hypertepsia

hypersensitivity to ibuprofen or to components of the drug

complete or incomplete syndrome of intolerance to acetylsalicylic acid (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma)

diseases of the optic nerve

violation of color vision, amblyopia, scotoma

deficiency of glucose-6-phosphate dehydrogenase, hemophilia and other blood clotting disorders, hemorrhagic diathesis, hypocoagulation state

pregnancy III trimester, lactation period

severe liver dysfunction

severe renal failure (creatipip clearance less than 30 ml / min)

hearing loss, pathology of the vestibular apparatus

the period after the aortocorporeal bypass grafting

gastrointestinal bleeding and intracranial hemorrhage

hemophilia and other blood clotting disorders, hemorrhagic diathesis

children under 6 years old.,

With care: old age, coronary heart disease, cerebrovascular disease, dyslipidemia, diabetes mellitus, peripheral artery disease, smoking, frequent alcohol consumption, prolonged use of HDL cholesterol, severe somatic diseases, concomitant use of oral corticosteroids (including prediizolone), anticoagulants ( including warfarin, clopidogrel, acetylsalicylic acid), taking selective serotonin reuptake inhibitors, diseases when taking the drug in patients with gastric ulcer and 12 duodenal ulcer in history, with gastritis, enteritis, colitis, with anamnestic information about bleeding from the gastrointestinal tract in the presence of concomitant liver and / or kidney diseases with cirrhosis of the liver with portal hypertension, nephrotic syndrome, chronic heart failure arterial hypertension with blood diseases of unknown etiology (leukopenia and anemia) with bronchial asthma, with hyperbilirubinemia pregnancy (I, II trimesters) age under 12.

INN / Active ingredient

Ibuprofen

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 3 years

Specifications

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the medicinal product

General

Release form

Tablet

Manufacturer country

Great Britain

Package quantity, pcs

8

Vacation conditions

Without recipe

Brand name

Nurofen

The amount of the dosage form in the primary package

8 pcs.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

NSAIDs

Anatomical and therapeutic characteristics

M01AE01 Ibuprofen

Dosage form

Film-coated tablets

The target audience

Children

Dosage (volume) of the substance in the preparation

200 mg

Expiration date in days

1095

Package weight, g

15

Mode of application

:

From 6 to 12 years old - 1 tablet no more than 4 times a day.

< br> From 12 years old - 1 tablet 3-4 times a day.

< br> Do not exceed 6 tablets in 24 hours.

< br> The intervals between taking the drug should be at least 6 hours.

Information on technical characteristics, delivery set, country of manufacture "