Nurofen Express Forte caps. 400mg # 10

Release form, composition and packaging

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Soft gelatine capsules, oval, translucent, red, with an identifying inscription NUROFEN" in white

the contents of the capsules are clear liquid from colorless to light pink.

1 caps.

ibuprofen 400 mg

macrogol 600 - 335.3 mg, potassium hydroxide - 44.82 mg, water - 29.88 mg.

Shell composition: gelatin - 197 mg, sorbitol (partially dehydrated) - 95.68 mg, water - 25.02 mg, crimson dye [Ponso 4R] (E124) - 0.79 mg, white ink [Opakod WB NS-78-18011] (water - 48 %, titanium dioxide (E171) - 29%, propylene glycol - 10%, isopropanol - 8%, hypromellose 3cP - 5%).

4 things.

- blisters (1) - cardboard packs.

4 things.

- blisters (2) - cardboard packs.

8 pcs.

- blisters (1) - cardboard packs.

8 pcs.

- blisters (2) - cardboard packs.

10 pieces.

- blisters (1) - cardboard packs.

10 pieces.

- blisters (2) - cardboard packs.

10 pieces.

- blisters (3) - cardboard packs.

pharmachologic effect

The mechanism of action of ibuprofen, a propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.

Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of prostaglandins.

Has a fast directed action against pain (analgesic), antipyretic and anti-inflammatory action.

In addition, ibuprofen reversibly inhibits platelet aggregation.

Pharmacokinetics

Absorption and distribution Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract. After taking 2 capsules of the drug on an empty stomach, ibuprofen is found in the blood plasma after 15 minutes, Cmax of ibuprofen in the blood plasma is reached after 30-40 minutes, which is 2 times faster than after taking an equivalent dose of Nurofen® in the dosage form, coated tablets 200 mg. Taking the drug with food can increase Tmax. Plasma protein binding over 90%. It slowly penetrates into the joint cavity, remains in the synovial fluid, creating higher concentrations in it than in the blood plasma. Metabolism and excretion After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver. T1 / 2 - 2 hours. Excreted by the kidneys (unchanged, no more than 1%) and,to a lesser extent, with bile. In limited studies, ibuprofen has been found in breast milk at very low concentrations. Pharmacokinetics in special groups of patients In the elderly, there were no significant differences in the pharmacokinetic profile of the drug compared with younger people.

Indications for use

- headache

- migraine

- toothache

- painful menstruation

- neuralgia

- back pain

- muscle pain

- rheumatic pains

- a fever with flu and colds.

Contraindications for use

- hypersensitivity to ibuprofen or any of the components that make up the drug - complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including in history) - erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or bleeding ulcer) - a history of bleeding or perforation of gastrointestinal ulcers, provoked by the use of NSAIDs - severe liver failure or liver disease in the active phase - renal failure of severe severity (CC < 30 ml / min), confirmed hyperkalemia - decompensated heart failure period after coronary artery bypass grafting - cer

Name ENG

NUROFEN EXPRESS FORTE

Clinical and pharmacological group

NSAIDs

ATX code

Ibuprofen

Dosage

400mg

Structure

One capsule contains the active ingredient - ibuprofen 400 mg, excipients: macrogol-600 335.3 mg, potassium hydroxide 44.82 mg, water 29.88 mg

capsule shell: gelatin 197 mg, sorbitol (partially dehydrated) 95.68 mg, water 25.02 mg, crimson dye [Ponso 4R] (E124) 0.79 mg, white ink [Opakod WB NS-78-18011] (water 48%, titanium dioxide (E171) 29%, propylene glycol 10%, isopropanol 8%, hypromellose 3cP 5%).

Indications

headache

migraine

toothache

painful periods

neuralgia

back pain

joint pain

muscle pain

rheumatic pains

fever with flu and colds.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 3 years

INN / Active ingredient

ibuprofen

Contraindications

hypersensitivity to ibuprofen or any of the components that make up the drug

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including in history)

erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding)

a history of bleeding or perforation of a gastrointestinal ulcer, provoked by the use of NSAIDs

severe liver failure or active liver disease

renal failure of severe severity (CC < 30 ml / min), confirmed hyperkalemia

decompensated heart failure

period after coronary artery bypass grafting

cerebrovascular or other bleeding

intolerance to fructose

hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis

III trimester of pregnancy

children under 12 years of age.

Precautions for use

If you have the conditions listed in this section, you should consult your doctor before using the drug.

Concomitant use of other NSAIDs, a history of a single episode of gastric ulcer or gastrointestinal ulcer bleeding gastritis, enteritis, colitis, presence of Helicobacter pylori infection, ulcerative colitis bronchial asthma or allergic diseases in the exacerbation phase or in history - the development of bronchospasm is possible systemic lupus erythematosus or mixed connective tissue disease (Sharp's syndrome) - increased risk of aseptic meningitis renal failure, incl. with dehydration (CC less than 30-60 ml / min), nephrotic syndrome, hepatic failure, liver cirrhosis with portal hypertension, hyperbilirubinemia, arterial hypertension and / or heart failure, cerebrovascular diseases, blood diseases of unknown etiology (leukopenia and anemia), severe somatic diseases, dyslipidemia / hyperlipidemia,diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, phenylketonuria or phenylalanine intolerance, concomitant use of drugs that can increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisone), anticoagulants (including including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, breastfeeding, elderly age.in particular, oral corticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including . acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, period of breastfeeding, old age.in particular, oral corticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including . acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, period of breastfeeding, old age.

Specifications

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the medicinal product

General

Release form

Capsules

Manufacturer country

Netherlands

Package quantity, pcs

ten

Minimum age from

12 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Nurofen

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

NSAIDs

Anatomical and therapeutic characteristics

M01AE01 Ibuprofen

Dosage form

Capsules

Dosage (volume) of the substance in the preparation

Ibuprofen 400 mg

Expiration date in days

1095

Package weight, g

twenty

Mode of application

:

Read the instructions carefully before taking the drug.

For oral administration.

For short term use only.

Adults and children over 12 years of age: orally 1 capsule without chewing.

The capsule should be taken with water.

The interval between doses of the drug should be at least 4 hours.

The maximum daily dose is 1200 mg.

The maximum daily dose for children 12-17 years old is 800 mg.

If, after taking the drug for 2-3 days, the symptoms persist or worsen, you must stop treatment and consult a doctor.

Information on technical characteristics, delivery set, country of manufacture "