Novocaine solution 0.5%, 10ml No. 10

Infiltration, conduction, epidural and spinal anesthesia, intraosseous anesthesia, mucosal anesthesia (in ENT practice); vagosympathetic and perirenal blockade. Circular and paravertebral blockade for eczema, neurodermatitis, ischalgia.

I / O: to potentiate the action of basic drugs for anesthesia; for relief of pain syndrome of various origins.

V / m: to dissolve penicillin in order to lengthen its duration; as an aid for certain diseases that are more common in old age, incl. endarteritis, atherosclerosis, arterial hypertension, spasms of the coronary vessels and cerebral vessels, diseases of the joints of rheumatic and infectious genesis.

Novocaine is injected intramuscularly - 5-10 ml of 1-2% solution 3 times a week for a month, after which a 10-day break is taken;

for infiltration anesthesia, 0.25-0.5% solutions are used, for conduction anesthesia - 2% solution.

Solution for infusion 0.5%

procaine

Hypersensitivity to procaine.

pharmachologic effect

Local anesthetic with moderate anesthetic activity and wide therapeutic range. Being a weak base, it blocks sodium channels, displaces calcium from receptors located on the inner surface of the membrane and, thus, prevents the generation of impulses in the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses conduction of not only painful, but also impulses of a different modality. When it enters the systemic circulation, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from the preganglionic endings (has a weak ganglion blocking effect), eliminates smooth muscle spasm,reduces the excitability of the myocardium and motor areas of the cerebral cortex.

Compared with lidocaine and bupivacaine, procaine has a less pronounced anesthetic effect and, therefore, has a relatively low toxicity and a greater therapeutic range.

Pharmacokinetics

Poorly absorbed through mucous membranes. When administered parenterally, it is well absorbed, rapidly hydrolyzed by plasma and tissue esterases with the formation of two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating effect) and PABA. T1 / 2 - 0.7 min. It is excreted mainly by the kidneys in the form of metabolites - 80%.

Indications of active substances of the drug Novocain

Infiltration, conduction, epidural and spinal anesthesia, intraosseous anesthesia, mucosal anesthesia (in ENT practice); vagosympathetic and perirenal blockade. Circular and paravertebral blockade for eczema, neurodermatitis, ischalgia.

I / O: to potentiate the action of basic drugs for anesthesia; for relief of pain syndrome of various origins.

V / m: to dissolve penicillin in order to lengthen its duration; as an aid for certain diseases that are more common in old age, incl. endarteritis, atherosclerosis, arterial hypertension, spasms of the coronary vessels and cerebral vessels, diseases of the joints of rheumatic and infectious genesis.

Side effect

Possibly: arterial hypotension, collapse, dizziness, weakness, urticaria, allergic reactions, anaphylactic shock.

Contraindications for use

Hypersensitivity to procaine.

special instructions

It should be borne in mind that when conducting local anesthesia when using the same total dose, the toxicity of procaine is the higher, the more concentrated the solution used is.

Procaine slowly penetrates through intact mucous membranes, therefore it is not very effective for surface anesthesia.

As an adjuvant, procaine is used intravenously and orally for arterial hypertension, late toxicosis of pregnant women with hypertensive syndrome, spasms of blood vessels, phantom pain, gastric ulcer and duodenal ulcer, NUC, itching, neurodermatitis, eczema, keratitis, iridocyclitis.

Drug interactions

When administered intravenously, it enhances the depressing effect on the central nervous system of agents for general anesthesia, hypnotics, sedatives, narcotic analgesics and tranquilizers.

The procaine metabolite PABA is a competitive antagonist of sulfonamides and can weaken their antimicrobial action.