Normax tablets 400mg, No. 6

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• diseases of the urinary tract;

• infections of the pelvic organs (including adnexitis, prostatitis);

• intestinal infections;

• infections of the skin and soft tissues;

• infections of the paranasal sinuses, pharynx, larynx, middle ear;

• ophthalmic infections.

Inside take 400 mg 2 times / day. For severe infections, a single dose can be increased to 800 mg. The duration of treatment is determined individually. The minimum course of treatment is 3 days.

Film-coated tablets of white or almost white color, capsule-shaped, with a score on one side.

1 tab.

norfloxacin 400 mg

Excipients: microcrystalline cellulose, purified talc, sodium starch glycolate, colloidal silicon dioxide, sodium lauryl sulfate, magnesium stearate, hydroxypropyl methylcellulose, titanium dioxide.

• Children and adolescents up to 18 years old;

• pregnancy;

• lactation (breastfeeding);

• hypersensitivity to norfloxaccine and other fluoroquinolone drugs.

pharmachologic effect

An antibacterial drug from the fluoroquinolone group. Possesses a wide spectrum of bactericidal action. Highly active against gram-negative bacteria: Escherichia coli, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp. (including Klebsiella pneumoniae), Morganella morganii, Neisseria spp. (including Neisseria gonorrhoeae), Salmonella spp., Shigella spp., Proteus spp., Pseudomonas aeruginosa, Enterobacter spp., Chlamydia trachomatis, Citrobacter freundii, Serratia spp., Yersinia spp. Active against gram-positive bacteria: Staphylococcus aureus (including strains producing penicillinase and methicillin-resistant strains), Staphylococcus epidermidis, Staphylococcus saprophyticus, some strains of Streptococcus spp. Enterococcus spp. Are not very sensitive to the drug. and Acinetobacter spp. Anaerobic bacteria are resistant to Normax.Pharmacokinetics When taken orally, 30-40% of the dose is absorbed, food intake reduces the rate of absorption. Norfloxacin is well distributed in the tissues of the genitourinary system. About 30% of the active substance is excreted unchanged in the urine.

Side effect

From the digestive system: nausea, heartburn, anorexia, diarrhea, abdominal pain. From the side of the central nervous system: headache, dizziness, fatigue, sleep disorders, irritability, anxiety. From the urinary system: interstitial nephritis is possible. Allergic reactions: if taken orally, skin rash, itching, Quincke's edema are possible.

Application during pregnancy and lactation

The drug is not recommended for use during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Normax in the form of tablets should be used with caution in patients with severely impaired liver function.

Application for impaired renal function

Normax in the form of tablets should be used with caution in patients with severe renal impairment.

special instructions

Normax in the form of tablets should be used with caution in patients with epilepsy, convulsive syndrome of a different etiology, severe impaired liver and / or kidney function. The drug should be taken at least 2 hours before or 2 hours after taking antacids or preparations containing iron, magnesium, zinc or sucralfate. Normax in the form of drops is intended for topical use only. To achieve the best therapeutic effect, drops should be used in combination with systemic antimicrobial therapy (except in mild cases). The solution and dropper should be protected from contamination.

Influence on the ability to drive vehicles and use mechanisms

Within 30 minutes after instilling the drug in the eyes, one should refrain from engaging in potentially hazardous activities that require increased attention.

Overdose

Currently, no cases of overdose of the drug Normax have been reported. Possible symptoms of accidental ingestion of drops inside: nausea, vomiting, diarrhea, headache, dizziness, anxiety.

Treatment: if necessary, carry out symptomatic therapy; it is necessary to ensure a sufficient flow of fluid into the body, the creation of an acidic urine reaction to prevent crystalluria.

Drug interactions

With the simultaneous administration of Normaks and warfarin, the anticoagulant effect of the latter is enhanced. With the simultaneous administration of Normax and cyclosporine, an increase in the concentration of the latter in the blood plasma is noted. With the simultaneous administration of Normax with antacids or preparations containing iron, magnesium, calcium, zinc, sucralfate, the absorption of norfloxacin is reduced due to the formation of complexones with metal ions. Pharmaceutical interactions Norfloxacin solution is incompatible with drugs with a pH value of 3-4, which are physically or chemically unstable.