Normase syrup 667 mg / ml fl. 200ml
Category
Laxatives
Scope of the medicinal product
Gastrointestinal tract
Release form
Syrup
Manufacturer country
Italy
Package quantity, pcs
one
Release form, composition and packaging
The syrup is transparent, colorless or light yellow with a brownish shade.
100 g
lactulose 66.7 g
citric acid - 0.05 g, creamy flavor (No. 7 bis) - 0.06 g, purified water - up to 100 ml.
Flavor composition: propylene glycol, dihydrocoumarin, vanillin.
200 ml - dark glass bottles (1) complete with a measuring cup - cardboard packs.
pharmachologic effect
Laxative.
It has a hyperosmotic, hypoammoniemic, laxative effect, stimulates intestinal motility, improves the absorption of phosphates and calcium salts.
Under the influence of the drug, the flora of the colon changes (an increase in the number of lactobacilli), which leads to an increase in acidity in the lumen of the colon and stimulates peristalsis.
Along with this, the volume increases and the feces soften.
As a result, the drug has a laxative effect without directly affecting the mucous membrane and smooth muscles of the colon.
Under the action of the drug, ammonia passes from the blood into the intestine, while the formation of nitrogen-containing toxic substances in its proximal section decreases and, accordingly, their absorption into the vena cava system.
The action can occur quickly or be delayed - after 24-48 hours.
Has the ability to inhibit the growth of Salmonella in the colon.
Does not decrease absorption of vitamins and is not addictive.
Pharmacokinetics
The absorption is low.
It is excreted through the intestines unchanged, 3% is excreted by the kidneys.
Indications for use
- chronic constipation
- regulation of stool in case of hemorrhoids, the need for surgery on the colon and in the anus, in the postoperative period
- hepatic precoma and coma
- hepatic encephalopathy
- hyperammonemia
- dysbiosis
- salmonellosis (except for generalized forms).
Contraindications for use
- intolerance to galactose or fructose
- galactosemia
- intestinal obstruction
- rectal bleeding (not hemorrhoidal)
- colostomy, ileostomy
- suspicion of appendicitis
- hypersensitivity to drug components.
The drug should be used with caution in diabetes mellitus.
Dosage regimen
The drug should be taken orally after meals.
For constipation, adults in the first 3 days are prescribed 15-40 ml / day, then 10-25 ml / day.
Children over 6 years old are prescribed 15 ml / day for the first 3 days, then 10 ml / day, at the age of 1-6 years - 5-10 ml / day, at the age of up to 1 year - 5 ml / day.
The duration of treatment is from 4 weeks to 3-4 months.
In hepatic coma, precoma, encephalopathy and hyperammonemia, the initial dose is 30-60 ml 3 times / day.
Then the dose is selected so that the soft stool is 2-3 times / day.
Treatment can last up to 3 months or more.
In the postoperative period, adults are prescribed 10-30 ml 3 times / day, children over 1 year old - 5-10 ml 2-3 times / day, under 1 year old - 5 ml 2-3 times / day.
The drug is prescribed 18-24 hours after surgery for 3-5 days.
Overdose
Data on drug overdose are not provided to Normase.
Side effect
From the digestive system: flatulence, nausea, diarrhea.
When using the drug in high doses for a long time in the treatment of hepatic encephalopathy due to diarrhea, the development of disorders of water and electrolyte metabolism is possible.
Drug interactions
With the simultaneous use of antibiotics and antacids, the effectiveness of lactulose is reduced.
Lactulose alters the pH-dependent release of enteric drugs.
It is not recommended to take lactulose within 2 hours after taking other medicines.
Application during pregnancy and lactation
Lactulose is safe when used during pregnancy and lactation (breastfeeding).
Special instructions
Name ENG
NORMASE
Clinical and pharmacological group
A laxative drug with osmotic properties.
Hypoammonic remedy
ATX code
Lactulose
Dosage
667mg / ml x 200ml
Structure
100 ml of syrup contains: active substance: lactulose solution (in terms of lactulose) 66.7 mg
excipients: citric acid
purified water
cream flavoring No. 7 bis (propylene glycol, dihydrocoumarin, vanillin).
Indications
chronic constipation
regulation of stool in case of hemorrhoids, the need for surgery on the colon and in the anus, in the postoperative period
hepatic precoma and coma, hepatic encephalopathy, hyperammonemia
dysbacteriosis, salmonellosis (except for generalized forms)
putrid dyspepsia syndrome in young children as a result of food poisoning.
Storage conditions and periods
At a temperature of 15-25 degrees (do not freeze).
Expiration date: 3 years
Contraindications
hypersensitivity
intolerance to galactose or fructose
galactosemia
intestinal obstruction
rectal bleeding, colo-, ileostomy
suspicion of appendicitis.
With care: diabetes mellitus.
INN / Active ingredient
lactulose
Specifications
Category
Laxatives
Scope of the medicinal product
Gastrointestinal tract
Release form
Syrup
Manufacturer country
Italy
Package quantity, pcs
one
Minimum age from
6 years
Way of introduction
Through the mouth
Vacation conditions
Without recipe
Brand name
L. Molteni & C. dei Fratelli Alliti Societa
Components
measuring glass
The amount of the dosage form in the primary package
200 ml
Primary packaging type
Bottle
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Laxative
Anatomical and therapeutic characteristics
A06AD11 Lactulose
Dosage form
Syrup
The target audience
Children
Expiration date in days
1095
Dosage (volume) of the substance in the preparation
lactulose 66.7 g
Package weight, g
315
Mode of application
:
For constipation, adults in the first 3 days are prescribed 15-40 ml / day, then 10-25 ml / day. Children over 6 years old - in the first 3 days, 15 ml / day is prescribed, then 10 ml / day, at the age of 1-6 years - 5-10 ml / day, at the age of 1 year - 5 ml / day. The duration of treatment is from 4 weeks to 3-4 months. < br> < br> With hepatic coma, precoma, encephalopathy and hyperammonemia, the initial dose is 30-60 ml 3 times / day. Then the dose is selected so that the stool is soft 2-3 times a day. Treatment can last up to 3 months or more. < br> < br> In the postoperative period, adults are prescribed 10-30 ml 3 times a day, children over 1 year old - 5-10 ml 2-3 times a day, up to 1 year - 5 ml 2-3 times a day. The drug is prescribed 18-24 hours after surgery for 3-5 days.
Information on technical characteristics, delivery set, country of manufacture