Normase syrup 667mg / ml, 200ml

• chronic constipation;

• regulation of stool in case of hemorrhoids, the need for surgery on the colon and in the anus, in the postoperative period;

• hepatic precoma and coma;

• hepatic encephalopathy;

• hyperammonemia;

• dysbiosis

• ; salmonellosis (with the exception of generalized forms).

The drug should be taken orally after meals.

For constipation, adults in the first 3 days are prescribed 15-40 ml / day, then 10-25 ml / day. Children over 6 years old are prescribed 15 ml / day for the first 3 days, then - 10 ml / day, at the age of 1-6 years - 5-10 ml / day, at the age of up to 1 year - 5 ml / day.

Duration of treatment is from 4 weeks to 3-4 months.

In hepatic coma, precoma, encephalopathy and hyperammonemia, the initial dose is 30-60 ml 3 times / day. Then the dose is selected so that the stool is soft 2-3 times / day. Treatment can last up to 3 months or more.

In the postoperative period, adults are prescribed 10-30 ml 3 times / day, children over 1 year old - 5-10 ml 2-3 times / day, under 1 year old - 5 ml 2-3 times / day. The drug is prescribed 18-24 hours after surgery for 3-5 days.

lactulose

• intolerance to galactose or fructose;

• galactosemia;

• intestinal obstruction;

• rectal bleeding (not hemorrhoidal);

• colostomy, ileostomy;

• suspicion of appendicitis;

• hypersensitivity to the components of the drug.

• The drug should be used with caution in diabetes mellitus.

pharmachologic effect

Laxative. It has a hyperosmotic, hypoammoniemic, laxative effect, stimulates intestinal peristalsis, improves the absorption of phosphates and calcium salts. Under the influence of the drug, the flora of the colon changes (an increase in the number of lactobacilli), which leads to an increase in acidity in the lumen of the colon and stimulates peristalsis. Along with this, the volume increases and the feces soften. As a result, the drug has a laxative effect without directly affecting the mucous membrane and smooth muscles of the colon. Under the action of the drug, ammonia passes from the blood into the intestine, while the formation of nitrogen-containing toxic substances in its proximal section decreases and, accordingly, their absorption into the vena cava system.The action can occur quickly or be delayed - after 24-48 hours. Has the ability to inhibit the growth of Salmonella in the colon. Does not decrease absorption of vitamins and is not addictive.

Pharmacokinetics

The absorption is low. It is excreted through the intestines unchanged, 3% is excreted by the kidneys. Side effect

From the digestive system: flatulence, nausea, diarrhea. When using the drug in high doses for a long time in the treatment of hepatic encephalopathy due to diarrhea, the development of violations of water and electrolyte metabolism is possible. Application during pregnancy and lactation Lactulose is safe when used during pregnancy and lactation (breastfeeding).

Application in children

It can be used according to indications and in doses that take into account the patient's age.

special instructions

With prolonged use of the drug (more than 6 months), the content of potassium, chlorine and carbon dioxide in the blood plasma should be regularly monitored. With gastrocardiac syndrome, doses should be gradually increased to avoid flatulence. Overdose

Data on drug overdose are not provided to Normase.

Drug interactions

With the simultaneous use of antibiotics and antacids, the effectiveness of lactulose is reduced. Lactulose alters the pH-dependent release of enteric drugs. It is not recommended to take lactulose within 2 hours after taking other medicines.