Norepynefryn | Norepinephrine agetan ampoules 2 mg / ml 8 ml, 10 pcs.
Special Price
$44.16
Regular Price
$57.00
In stock
SKU
BID496605
Latin name
Noradrenaline Aguettant
Noradrenaline Aguettant
Latin name
Noradrenaline Aguettant
Release form
Concentrate for preparing a solution for intravenous injection
Packing
10 pcs
Pharmacological action
Norepinephrine agetan - adrenomimetic.
Pharmacodynamics
l- and 2-adrenergic receptor agonist. It weakly excites 1 - and practically does not affect 2-adrenergic receptors. It has a powerful vasoconstrictor effect, leads to an increase in blood pressure.
Pharmacokinetics
Not absorbed in the digestive tract. With iv administration, it rapidly reaches Cmax in plasma (within 2–3 min).
Metabolized in the liver, kidneys and blood plasma with the participation of MAO and catechol-O-methyltransferase (COMT) to almost inactive metabolites that are excreted through the kidneys.
Indications
Acute hypotension accompanying cardiovascular collapse and shock (to restore and maintain blood pressure - iv perfusion).
Contraindications
severe hypersensitivity to the drug
arterial hypotension due to hypovolemia. An exception in these cases is the need to administer the drug to maintain blood flow in the coronary arteries of the heart and brain arteries before the end of therapy aimed at restoring bcc
mesenteric and peripheral vascular thrombosis due to the risk of aggravating ischemia and enlarging the
infarction zone conducting fluorotan and cyclopropane general anesthesia due to the risk of ventricular tachycardia and fibrillation)
severe hypoxia and hypercapnia.
Precautions: severe left ventricular failure, acute heart failure, recent myocardial infarction
simultaneous administration of MAO inhibitors of imipramine and tryptiline series (due to the risk of developing a pronounced and prolonged increase in blood pressure)
development of symptoms of cardiac arrhythmia (in this case, a dose reduction is necessary). With polymorphic extrasystole or the development of volleys of extrasystoles, the dose of the drug should be significantly reduced or treatment canceled.
Use in pregnancy and lactation
Pregnancy is not a limitation for the use of Norepinephrine Agetan. At the time of treatment, breast-feeding should be stopped (there is no experience with the drug in nursing women).
Composition
1 ml. contains:
Active ingredient: norepinephrine tartrate monohydrate (in terms of norepinephrine tartrate) 2 mg / ml
Excipients: sodium chloride sodium hydroxide or hydrochloric acid (pH = 3.0ִ.5) water for injection.
Dosage and administration
Intravenously, preferably in the vein of the elbow.
Concentrate should be diluted in 5% glucose solution or 0.9% sodium chloride solution. Do not mix with other drugs. With the introduction of Noradrenaline Agetan, it is necessary to constantly monitor blood pressure and heart rate.
After diluting the concentrate, the solution should be used within 12 hours.
The individual dose is determined depending on the clinical condition of the patient. An initial dose and rate of administration of 0.1 to 0.3? G / kg / min of norepinephrine tartrate is recommended. The maximum dose and rate of administration used in the treatment of septic and hemorrhagic shock can reach 3–5? G / kg / min.
Side effects
With the administration of Norepinephrine Agetan, the following symptoms may occur: ischemic disorders up to necrosis, caused by vasoconstriction and tissue hypoxia, as well as caused by extravasation of
arrhythmia
reflex bradycardia
anxiety
shortness of breath
tremor
transient headache
chest pain, swallowing pain and swelling mild pain In especially sensitive patients, an increase in blood pressure may be accompanied by headache, photophobia, stitching chest pain, pallor of the skin, increased sweating and vomiting.
With prolonged use, a dose adjustment is necessary to avoid recurrent hypotension during drug withdrawal.
Drug interaction
The main undesirable effects when combined with some groups of drugs are pharmacodynamic.
Serious ventricular arrhythmias (increased cardiac irritability) may occur when combined with inhaled anesthetic drugs.
When combined with serotonergic and adrenergic antidepressants, and also derivatives of imipramine and amitriptyline, paroxysmal hypertension may develop with a risk of cardiac arrhythmia due to an adrenergic blocking effect on the sympathetic nervous system.
Combination of Norepinephrine Agetan with selective and non-selective MAO inhibitors, linezolid, is contraindicated. at the same time, a synergistic increase in the pressor action of norepinephrine occurs, which requires careful medical monitoring.
Overdose
Symptoms: skin vascular spasm, collapse, anuria, marked elevation of blood pressure may occur.
Treatment: In the event of overdose, the dose of the drug should be reduced.
Storage Conditions
In a dry, dark place at a temperature not exceeding 30 РC.
shelf life
2 years
Deystvuyushtee substance
Norэpinefrin
Terms of dispatch from
pharmacies Prescription of
dosage form
infusion solution
Possible product names
NORADRENALIN AGETAN 0, 002 / ML 8ML N10AMP END
Noradrenaline Agetan 2mg / ml conc. d / prg. solution for iv input. 8ml Amp. X10 B (R)
Norepinephrine agetan ampoules 2 mg / ml 8 ml, 10 pcs.
NORADRENALINE AGHETAN END. Prigot. R-RA I / O INTRODUCTION. 2MG / ML AMP. 8ML No. 10
NORADRENALIN AGETAN CONC. Prigot. R-RA I / O INTRODUCTION. 2MG / ML AMP. 8ML No. 10 (09.13)
Laboratory Agetan, France
Noradrenaline Aguettant
Release form
Concentrate for preparing a solution for intravenous injection
Packing
10 pcs
Pharmacological action
Norepinephrine agetan - adrenomimetic.
Pharmacodynamics
l- and 2-adrenergic receptor agonist. It weakly excites 1 - and practically does not affect 2-adrenergic receptors. It has a powerful vasoconstrictor effect, leads to an increase in blood pressure.
Pharmacokinetics
Not absorbed in the digestive tract. With iv administration, it rapidly reaches Cmax in plasma (within 2–3 min).
Metabolized in the liver, kidneys and blood plasma with the participation of MAO and catechol-O-methyltransferase (COMT) to almost inactive metabolites that are excreted through the kidneys.
Indications
Acute hypotension accompanying cardiovascular collapse and shock (to restore and maintain blood pressure - iv perfusion).
Contraindications
severe hypersensitivity to the drug
arterial hypotension due to hypovolemia. An exception in these cases is the need to administer the drug to maintain blood flow in the coronary arteries of the heart and brain arteries before the end of therapy aimed at restoring bcc
mesenteric and peripheral vascular thrombosis due to the risk of aggravating ischemia and enlarging the
infarction zone conducting fluorotan and cyclopropane general anesthesia due to the risk of ventricular tachycardia and fibrillation)
severe hypoxia and hypercapnia.
Precautions: severe left ventricular failure, acute heart failure, recent myocardial infarction
simultaneous administration of MAO inhibitors of imipramine and tryptiline series (due to the risk of developing a pronounced and prolonged increase in blood pressure)
development of symptoms of cardiac arrhythmia (in this case, a dose reduction is necessary). With polymorphic extrasystole or the development of volleys of extrasystoles, the dose of the drug should be significantly reduced or treatment canceled.
Use in pregnancy and lactation
Pregnancy is not a limitation for the use of Norepinephrine Agetan. At the time of treatment, breast-feeding should be stopped (there is no experience with the drug in nursing women).
Composition
1 ml. contains:
Active ingredient: norepinephrine tartrate monohydrate (in terms of norepinephrine tartrate) 2 mg / ml
Excipients: sodium chloride sodium hydroxide or hydrochloric acid (pH = 3.0ִ.5) water for injection.
Dosage and administration
Intravenously, preferably in the vein of the elbow.
Concentrate should be diluted in 5% glucose solution or 0.9% sodium chloride solution. Do not mix with other drugs. With the introduction of Noradrenaline Agetan, it is necessary to constantly monitor blood pressure and heart rate.
After diluting the concentrate, the solution should be used within 12 hours.
The individual dose is determined depending on the clinical condition of the patient. An initial dose and rate of administration of 0.1 to 0.3? G / kg / min of norepinephrine tartrate is recommended. The maximum dose and rate of administration used in the treatment of septic and hemorrhagic shock can reach 3–5? G / kg / min.
Side effects
With the administration of Norepinephrine Agetan, the following symptoms may occur: ischemic disorders up to necrosis, caused by vasoconstriction and tissue hypoxia, as well as caused by extravasation of
arrhythmia
reflex bradycardia
anxiety
shortness of breath
tremor
transient headache
chest pain, swallowing pain and swelling mild pain In especially sensitive patients, an increase in blood pressure may be accompanied by headache, photophobia, stitching chest pain, pallor of the skin, increased sweating and vomiting.
With prolonged use, a dose adjustment is necessary to avoid recurrent hypotension during drug withdrawal.
Drug interaction
The main undesirable effects when combined with some groups of drugs are pharmacodynamic.
Serious ventricular arrhythmias (increased cardiac irritability) may occur when combined with inhaled anesthetic drugs.
When combined with serotonergic and adrenergic antidepressants, and also derivatives of imipramine and amitriptyline, paroxysmal hypertension may develop with a risk of cardiac arrhythmia due to an adrenergic blocking effect on the sympathetic nervous system.
Combination of Norepinephrine Agetan with selective and non-selective MAO inhibitors, linezolid, is contraindicated. at the same time, a synergistic increase in the pressor action of norepinephrine occurs, which requires careful medical monitoring.
Overdose
Symptoms: skin vascular spasm, collapse, anuria, marked elevation of blood pressure may occur.
Treatment: In the event of overdose, the dose of the drug should be reduced.
Storage Conditions
In a dry, dark place at a temperature not exceeding 30 РC.
shelf life
2 years
Deystvuyushtee substance
Norэpinefrin
Terms of dispatch from
pharmacies Prescription of
dosage form
infusion solution
Possible product names
NORADRENALIN AGETAN 0, 002 / ML 8ML N10AMP END
Noradrenaline Agetan 2mg / ml conc. d / prg. solution for iv input. 8ml Amp. X10 B (R)
Norepinephrine agetan ampoules 2 mg / ml 8 ml, 10 pcs.
NORADRENALINE AGHETAN END. Prigot. R-RA I / O INTRODUCTION. 2MG / ML AMP. 8ML No. 10
NORADRENALIN AGETAN CONC. Prigot. R-RA I / O INTRODUCTION. 2MG / ML AMP. 8ML No. 10 (09.13)
Laboratory Agetan, France
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