Nixar tablets 20mg, No. 10

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen. Inside, 1 single dose once a day, one hour before meals or 2 hours after meals.

Pills

Active substance:

bilastine

Age up to 12 years, pregnancy and breastfeeding period.

pharmachologic effect

Long-acting antihistamine, selectively blocks peripheral H1 receptors.

A significant therapeutic effect is observed one hour after administration, the antihistamine effect lasts for 24 hours. Possibly insignificant penetration through the BBB. It has no anticholinergic effect. The lengthening of the QT interval on the ECG is not observed.

Indications of active substances of the drug NixarЃ

Allergic (seasonal and year-round) rhinoconjunctivitis, urticaria.

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen. Inside, 1 single dose once a day, one hour before meals or 2 hours after meals.

Side effect

Gastrointestinal disorders: dryness of the oral mucosa, diarrhea, dyspepsia, gastritis, pain in the upper abdomen, discomfort in the stomach, nausea.

Skin and subcutaneous tissue disorders: pruritus.

Nervous system disorders: drowsiness, headache, dizziness, anxiety, insomnia.

Metabolic disorders: increased appetite, weight gain.

Hearing disorders: tinnitus, vertigo.

Disturbances from the cardiovascular system: blockade of the right bundle branch, sinus arrhythmia, prolongation of the QT interval on the ECG, other changes on the ECG.

Others: herpetic lesions of the oral cavity, thirst, fatigue, asthenia, fever, an increase in the concentration of triglycerides in the blood plasma, an increase in the concentration of creatinine in the blood plasma, an increase in the activity of 'liver enzymes' (AST, ALT, gamma-glutamyltransferase).

Contraindications for use

Age up to 12 years, pregnancy and breastfeeding period.

Application during pregnancy and lactation

The use is contraindicated during pregnancy and during breastfeeding.

Application in children

The use is contraindicated in children under 12 years of age.

special instructions

In patients with moderate to severe renal insufficiency, caution should be exercised when used simultaneously with P-glycoprotein inhibitors (ketoconazole, erythromycin, cyclosporine, ritonavir, diltiazem, etc.).

Influence on the ability to drive vehicles and mechanisms

Dizziness, drowsiness may appear.

Drug interactions

When used simultaneously with ketoconazole or erythromycin, the area under the concentration-time curve increased 2 times, and Cmax - 2-3 times. Diltiazem increases Cmax by 50%. Grapefruit and other fruit juices reduce bioavailability by 30%. Medicines that are substrates or inhibitors of OATP1A2 (for example, ritonavir or rifampicin) can reduce the concentration of the drug in the blood plasma.