Nicotinic acid solution 1%, 1ml No. 10

Hypo- and avitaminosis PP: pellagra, inadequate and unbalanced nutrition (including parenteral), malabsorption syndrome (including against the background of dysfunction of the pancreas), rapid weight loss, gastrectomy, Hartnup's disease (hereditary disease accompanied by a violation assimilation of some amino acids, including tryptophan), gastrointestinal diseases (celiac disease, persistent diarrhea, tropical sprue, Crohn's disease).

Conditions of increased body demand for vitamin PP: prolonged fever, diseases of the hepatobiliary region (acute and chronic hepatitis, liver cirrhosis), hyperthyroidism, chronic infections, malignant tumors, prolonged stress, pregnancy (especially against the background of nicotine and drug addiction, multiple pregnancy), period lactation.

Hyperlipidemia, incl. primary hyperlipidemia (types IIa, IIb, III, IV, V).

Ischemic disorders of cerebral circulation, obliterating vascular diseases of the extremities (obliterating endarteritis, Raynaud's disease), vasospasm of the extremities, bile and urinary tract; diabetic polyneuropathy, microangiopathy.

Neuritis of the facial nerve, hypoacid gastritis, enterocolitis, colitis, long-term non-healing wounds and trophic ulcers.

In / in (slowly), in / m or s / c. Subcutaneous and intramuscular injection are painful.

With pellagra: 1% solution of 1 ml is parenterally administered 1Ц2 times a day for 10Ц15 days.

In ischemic stroke: IV, 1 ml of 1% solution.

Higher doses for adults: single - 100 mg, daily - 300 mg.

in ampoules of 1 ml (complete with an ampoule knife or ampoule scarifier); in a pack of cardboard 10 ampoules.

Hypersensitivity to niacin.

For oral administration: gastric ulcer and duodenal ulcer in the acute phase, children under 2 years of age (as a lipid-lowering agent).

For parenteral use: severe arterial hypertension, atherosclerosis, gout, hyperuricemia, childhood.

pharmachologic effect

Vitamin and lipid-lowering agent. In the body, nicotinic acid is converted to nicotinamide, which binds to the coenzymes of codehydrogenase I and II (NAD and NADP), which carry hydrogen, and is involved in the metabolism of fats, proteins, amino acids, purines, tissue respiration, glycogenolysis, and synthetic processes. Replenishes the deficiency of vitamin PP (vitamin B3), is a specific antipellagric agent (vitamin PP vitamin deficiency). Normalizes the concentration of blood lipoproteins; in high doses (inside 3-4 g / day) reduces the concentration of total cholesterol, LDL, TG, reduces the cholesterol / phospholipid index, increases the content of HDL, which has an antiatherogenic effect. It has a vasodilating effect at the level of small vessels (including the brain), improves microcirculation,has a weak anticoagulant effect (increases the fibrinolytic activity of the blood).

The hypocholesterolemic effect is noted after a few days, the decrease in TG - a few hours after ingestion.

Indications of the active substances of the drug Nicotinic acid

Hypo- and avitaminosis PP: pellagra, inadequate and unbalanced nutrition (including parenteral), malabsorption syndrome (including against the background of dysfunction of the pancreas), rapid weight loss, gastrectomy, Hartnup's disease (hereditary disease accompanied by a violation assimilation of some amino acids, including tryptophan), gastrointestinal diseases (celiac disease, persistent diarrhea, tropical sprue, Crohn's disease).

Conditions of increased body demand for vitamin PP: prolonged fever, diseases of the hepatobiliary region (acute and chronic hepatitis, liver cirrhosis), hyperthyroidism, chronic infections, malignant tumors, prolonged stress, pregnancy (especially against the background of nicotine and drug addiction, multiple pregnancy), period lactation.

Hyperlipidemia, incl. primary hyperlipidemia (types IIa, IIb, III, IV, V).

Ischemic disorders of cerebral circulation, obliterating vascular diseases of the extremities (obliterating endarteritis, Raynaud's disease), vasospasm of the extremities, bile and urinary tract; diabetic polyneuropathy, microangiopathy.

Neuritis of the facial nerve, hypoacid gastritis, enterocolitis, colitis, long-term non-healing wounds and trophic ulcers.

Dosage regimen

For the prevention of pellagra for adults inside 15-25 mg / day, for children - 5-20 mg / day. With pellagra for adults, 100 mg orally 2-4 times / day for 15-20 days, parenteral - 10 mg 1-2 times / day for 10-15 days. Children inside - 5-50 mg 2-3 times / day. For other indications, inside adults 20-50 mg (up to 100 mg), children - 5-30 mg 2-3 times / day. With ischemic stroke, 10 mg is administered intravenously.

Side effect

From the side of the cardiovascular system: hyperemia of the skin of the face and upper half of the body with a tingling sensation and burning, with rapid administration - a decrease in blood pressure, orthostatic hypotension, collapse.

From the side of the central nervous system and peripheral nervous system: paresthesia, dizziness.

From the digestive system: with prolonged use - fatty degeneration of the liver.

From the side of metabolism: with prolonged use - hyperuricemia, decreased glucose tolerance, increased blood levels of AST, LDH, ALP.

Local reactions: soreness at the site of s / c and i / m injections.

Others: allergic reactions.

Contraindications for use

Hypersensitivity to niacin.

For oral administration: gastric ulcer and duodenal ulcer in the acute phase, children under 2 years of age (as a lipid-lowering agent).

For parenteral use: severe arterial hypertension, atherosclerosis, gout, hyperuricemia, childhood.

Application for violations of liver function

Use with caution in patients with hepatic impairment.

With prolonged use of nicotinic acid in high doses, it is possible to develop fatty liver infiltration.

During treatment, it is necessary to monitor liver function. To prevent complications from the liver, it is recommended to include in the diet foods rich in methionine (cottage cheese) or to use methionine, lipoic acid and other lipotropic agents.

Application in children

Contraindications:

• for oral administration: children under 2 years of age (as a lipid-lowering agent).

• for parenteral use: children.

special instructions

Use with caution orally in patients with hemorrhages, glaucoma, gout, hyperuricemia, liver failure, arterial hypotension, hyperacid gastritis, gastric ulcer and duodenal ulcer (in remission).

Use parenterally with caution in patients with hemorrhages, glaucoma, liver failure, arterial hypotension, hyperacid gastritis, gastric ulcer and duodenal ulcer (in the acute phase).

With prolonged use of nicotinic acid in high doses, it is possible to develop fatty liver infiltration.

During treatment, it is necessary to monitor liver function.

It is inappropriate to use for the correction of dyslipidemia in patients with diabetes mellitus.

To prevent complications from the liver, it is recommended to include in the diet foods rich in methionine (cottage cheese) or to use methionine, lipoic acid and other lipotropic agents.

Drug interactions

Care must be taken when combined with antihypertensive drugs, anticoagulants and acetylsalicylic acid.

Nicotinic acid reduces the toxicity of neomycin and prevents the reduction in cholesterol and HDL levels it induces.