Next tab. p / o captivity. 400mg + 200mg # 10

Special Price $9.70 Regular Price $18.00
In stock
SKU
OTC10201020
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Package quantity, pcs:

6

ten

twenty

Release form:

Capsules

Tablet

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the medicinal product

General

Release form

Tablet

Manufacturer country

Russia

Package quantity, pcs

ten

Description

Release form, composition and packaging

Tablets, film-coated red, oval, biconvex, with a risk, on a cross section the core is white or almost white.

1 tab.

ibuprofen 400 mg

paracetamol 200 mg

calcium hydrogen phosphate (Fujicalin) - 80 mg, microcrystalline cellulose - 64.5 mg, croscarmellose sodium - 24.3 mg, hyprolose (hydroxypropyl cellulose (Klucel EF)) - 19.3 mg, talc - 12.1 mg, magnesium stearate - 7.3 mg, colloidal silicon dioxide (aerosil) - 2.5 mg. Shell composition: Opadry 20A250004 Red (Opadry 20A250004 Red) [hypromellose (hydroxypropyl methylcellulose) - 13.1 mg, hyprolose (hydroxypropyl cellulose) - 8.1 mg, talc - 6.4 mg, titanium dioxide - 2.5 mg, crimson dye [Ponso 4R] (E124) - 0.9 mg, dye sunset yellow (E110) - 0.5 mg] - 31.5 mg Opadry II 85F19250 Transparent (Opadry II 85F19250 Clear) [macrogol (polyethylene glycol) - 0.3 mg, polyvinyl alcohol - 1 mg, polysorbate 80 - 0.1 mg, talc - 0.6 mg] - 2 mg. 2 pcs. - contour cell packaging (1) - cardboard packs.

2 pcs.

- contour cell packages (2) - cardboard packs.

6 pcs.

- contour cell packaging (1) - cardboard packs.

6 pcs.

- contour cell packages (2) - cardboard packs.

10 pieces.

- contour cell packaging (1) - cardboard packs.

10 pieces.

- contour cell packages (2) - cardboard packs.

12 pcs.

- contour cell packaging (1) - cardboard packs.

12 pcs.

- contour cell packages (2) - cardboard packs.

pharmachologic effect

The combined preparation has an analgesic, anti-inflammatory and antipyretic effect.

Paracetamol is a non-narcotic analgesic that has antipyretic and analgesic effects due to the blockade of COX in the central nervous system and the effect on the centers of pain and thermoregulation.

Ibuprofen is an NSAID that has analgesic, anti-inflammatory and antipyretic effects associated with non-selective suppression of COX activity, which regulates prostaglandin synthesis.

The components of the drug affect both the central and peripheral mechanisms of the formation of pain syndrome.

The targeted, complementary action of the two components has a quick therapeutic effect and a pronounced analgesic effect.

Pharmacokinetics

Paracetamol Absorption - high, Cmax is 5-20 μg / ml, Tmax - 0.5-2 hours

binding to plasma proteins - 15%.

Penetrates the BBB.

It is metabolized in the liver, with the formation of both active and inactive metabolites.

T1 / 2 - 1-4 hours. Mainly excreted by the kidneys in the form of metabolites - glucuronides and sulfates, 3% - unchanged.

Ibuprofen Well absorbed from the gastrointestinal tract.

Tmax when taken on an empty stomach - 45 minutes, when taken after meals - 1.5-2.5 hours. Plasma protein binding - 90%.

The concentration of the drug in the synovial fluid exceeds the content in the plasma.

Undergoes presystemic and post-systemic metabolism in the liver.

Has a two-phase kinetics of excretion, T1 / 2 is 2-2.5 hours. It is excreted by the kidneys (unchanged, not more than 1%) and to a lesser extent - with bile.

Indications for use

- headache (including migraine)

- toothache

- algodismenorrhea

- neuralgia

- myalgia

- back pain

- joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system

- pain with bruises, sprains, dislocations, fractures

- post-traumatic and postoperative pain syndrome

- feverish conditions (including with flu and colds).

Contraindications for use

- hypersensitivity to drug components

- erosive and ulcerative diseases of the digestive tract (in the acute phase), gastrointestinal bleeding

- severe hepatic and / or renal impairment

- blood clotting disorders (hemophilia, prolongation of bleeding time, tendency to bleeding, hemorrhagic diathesis)

- complete or not

Name ENG

NEXT

Clinical and pharmacological group

NSAIDs in combination with an antipyretic analgesic

ATX code

Ibuprofen in combination with other drugs

Dosage

400mg + 200mg

Structure

1 tablet contains: Active ingredients: ibuprofen 400 mg, paracetamol 200 mg

Excipients: calcium hydrogen phosphate (Fujicalin), microcrystalline cellulose, croscarmellose sodium, hyprolose (hydroxypropyl cellulose (Klucel EF)), talc, magnesium stearate, colloidal silicon dioxide (aerosil

Indications

headache (including migraine)

toothache

algodismenorrhea (painful menstruation)

neuralgia

myalgia

back pain

joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system

pain with bruises, sprains, dislocations, fractures

post-traumatic and postoperative pain syndrome

feverish conditions (including flu and colds).

INN / Active ingredient

ibuprofen, paracetamol

Contraindications

hypersensitivity to drug components

erosive and ulcerative diseases of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding

severe hepatic and / or renal impairment

bleeding disorders (hemophilia, prolongation of bleeding time, tendency to bleeding, hemorrhagic diathesis)

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, incl.

history

condition after coronary artery bypass grafting

confirmed hyperkalemia

deficiency of glucose-6-phosphate dehydrogenase

children under 12 years of age.

Precautions: Chronic heart failure

viral hepatitis, alcoholic liver damage, hepatic and / or renal failure of moderate to mild severity, benign hyperbilirubinemia (Gilbert's, Dubin-Johnson's and Rotor's syndrome), cirrhosis of the liver with portal hypertension, nephrotic syndrome

diabetes mellitus, peripheral arterial disease, gastric ulcer and duodenal ulcer (in history)

gastritis, enteritis, colitis

bronchial asthma, bronchospasm

elderly age

pregnancy (I and II trimesters - use is possible only as directed by a doctor in cases where the potential benefit outweighs the possible risk).

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 2 years

Specifications

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the medicinal product

General

Release form

Tablet

Manufacturer country

Russia

Package quantity, pcs

ten

Minimum age from

12 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

OTCPharm

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Anatomical and therapeutic characteristics

M01AE51 Ibuprofen, in combination with other drugs

Dosage form

Film-coated tablets

Expiration date in days

730

The target audience

Children

Dosage (volume) of the substance in the preparation

400 mg + 200 mg

Package weight, g

ten

Mode of application

:

Next tablets are taken orally, after meals. < br> < br> Adults: 1 tablet 3 times a day.

The maximum daily dose is 3 tablets.

< br> Children over 12 years old (body weight over 40 kg): 1 tablet 2 times a day. < br> < br> Duration of treatment is not more than 3 days as an antipyretic agent and not more than 5 days as an anesthetic. < br> < br> Continuation of treatment with the drug is possible only after consulting a doctor.

Pharmaco-therapeutic group

:

Combined analgesic (NSAIDs + non-narcotic analgesic)

Information on technical characteristics, delivery set, country of manufacture

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