Next tab. p / o captivity. 400mg + 200mg # 10
Package quantity, pcs:
6
ten
twenty
Release form:
Capsules
Tablet
Category
Pain relievers
,
Migraine
,
Pain and fever
Scope of the medicinal product
General
Release form
Tablet
Manufacturer country
Russia
Package quantity, pcs
ten
Release form, composition and packaging
Tablets, film-coated red, oval, biconvex, with a risk, on a cross section the core is white or almost white.
1 tab.
ibuprofen 400 mg
paracetamol 200 mg
calcium hydrogen phosphate (Fujicalin) - 80 mg, microcrystalline cellulose - 64.5 mg, croscarmellose sodium - 24.3 mg, hyprolose (hydroxypropyl cellulose (Klucel EF)) - 19.3 mg, talc - 12.1 mg, magnesium stearate - 7.3 mg, colloidal silicon dioxide (aerosil) - 2.5 mg. Shell composition: Opadry 20A250004 Red (Opadry 20A250004 Red) [hypromellose (hydroxypropyl methylcellulose) - 13.1 mg, hyprolose (hydroxypropyl cellulose) - 8.1 mg, talc - 6.4 mg, titanium dioxide - 2.5 mg, crimson dye [Ponso 4R] (E124) - 0.9 mg, dye sunset yellow (E110) - 0.5 mg] - 31.5 mg Opadry II 85F19250 Transparent (Opadry II 85F19250 Clear) [macrogol (polyethylene glycol) - 0.3 mg, polyvinyl alcohol - 1 mg, polysorbate 80 - 0.1 mg, talc - 0.6 mg] - 2 mg. 2 pcs. - contour cell packaging (1) - cardboard packs.
2 pcs.
- contour cell packages (2) - cardboard packs.
6 pcs.
- contour cell packaging (1) - cardboard packs.
6 pcs.
- contour cell packages (2) - cardboard packs.
10 pieces.
- contour cell packaging (1) - cardboard packs.
10 pieces.
- contour cell packages (2) - cardboard packs.
12 pcs.
- contour cell packaging (1) - cardboard packs.
12 pcs.
- contour cell packages (2) - cardboard packs.
pharmachologic effect
The combined preparation has an analgesic, anti-inflammatory and antipyretic effect.
Paracetamol is a non-narcotic analgesic that has antipyretic and analgesic effects due to the blockade of COX in the central nervous system and the effect on the centers of pain and thermoregulation.
Ibuprofen is an NSAID that has analgesic, anti-inflammatory and antipyretic effects associated with non-selective suppression of COX activity, which regulates prostaglandin synthesis.
The components of the drug affect both the central and peripheral mechanisms of the formation of pain syndrome.
The targeted, complementary action of the two components has a quick therapeutic effect and a pronounced analgesic effect.
Pharmacokinetics
Paracetamol Absorption - high, Cmax is 5-20 μg / ml, Tmax - 0.5-2 hours
binding to plasma proteins - 15%.
Penetrates the BBB.
It is metabolized in the liver, with the formation of both active and inactive metabolites.
T1 / 2 - 1-4 hours. Mainly excreted by the kidneys in the form of metabolites - glucuronides and sulfates, 3% - unchanged.
Ibuprofen Well absorbed from the gastrointestinal tract.
Tmax when taken on an empty stomach - 45 minutes, when taken after meals - 1.5-2.5 hours. Plasma protein binding - 90%.
The concentration of the drug in the synovial fluid exceeds the content in the plasma.
Undergoes presystemic and post-systemic metabolism in the liver.
Has a two-phase kinetics of excretion, T1 / 2 is 2-2.5 hours. It is excreted by the kidneys (unchanged, not more than 1%) and to a lesser extent - with bile.
Indications for use
- headache (including migraine)
- toothache
- algodismenorrhea
- neuralgia
- myalgia
- back pain
- joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system
- pain with bruises, sprains, dislocations, fractures
- post-traumatic and postoperative pain syndrome
- feverish conditions (including with flu and colds).
Contraindications for use
- hypersensitivity to drug components
- erosive and ulcerative diseases of the digestive tract (in the acute phase), gastrointestinal bleeding
- severe hepatic and / or renal impairment
- blood clotting disorders (hemophilia, prolongation of bleeding time, tendency to bleeding, hemorrhagic diathesis)
- complete or not
Name ENG
NEXT
Clinical and pharmacological group
NSAIDs in combination with an antipyretic analgesic
ATX code
Ibuprofen in combination with other drugs
Dosage
400mg + 200mg
Structure
1 tablet contains: Active ingredients: ibuprofen 400 mg, paracetamol 200 mg
Excipients: calcium hydrogen phosphate (Fujicalin), microcrystalline cellulose, croscarmellose sodium, hyprolose (hydroxypropyl cellulose (Klucel EF)), talc, magnesium stearate, colloidal silicon dioxide (aerosil
Indications
headache (including migraine)
toothache
algodismenorrhea (painful menstruation)
neuralgia
myalgia
back pain
joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system
pain with bruises, sprains, dislocations, fractures
post-traumatic and postoperative pain syndrome
feverish conditions (including flu and colds).
INN / Active ingredient
ibuprofen, paracetamol
Contraindications
hypersensitivity to drug components
erosive and ulcerative diseases of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding
severe hepatic and / or renal impairment
bleeding disorders (hemophilia, prolongation of bleeding time, tendency to bleeding, hemorrhagic diathesis)
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, incl.
history
condition after coronary artery bypass grafting
confirmed hyperkalemia
deficiency of glucose-6-phosphate dehydrogenase
children under 12 years of age.
Precautions: Chronic heart failure
viral hepatitis, alcoholic liver damage, hepatic and / or renal failure of moderate to mild severity, benign hyperbilirubinemia (Gilbert's, Dubin-Johnson's and Rotor's syndrome), cirrhosis of the liver with portal hypertension, nephrotic syndrome
diabetes mellitus, peripheral arterial disease, gastric ulcer and duodenal ulcer (in history)
gastritis, enteritis, colitis
bronchial asthma, bronchospasm
elderly age
pregnancy (I and II trimesters - use is possible only as directed by a doctor in cases where the potential benefit outweighs the possible risk).
Storage conditions and periods
At a temperature not higher than 25 degrees.
Expiration date: 2 years
Specifications
Category
Pain relievers
,
Migraine
,
Pain and fever
Scope of the medicinal product
General
Release form
Tablet
Manufacturer country
Russia
Package quantity, pcs
ten
Minimum age from
12 years
Way of introduction
Through the mouth
Vacation conditions
Without recipe
Brand name
OTCPharm
The amount of the dosage form in the primary package
10 pieces.
Primary packaging type
Blister
Type of consumer packaging
Pack of cardboard
Anatomical and therapeutic characteristics
M01AE51 Ibuprofen, in combination with other drugs
Dosage form
Film-coated tablets
Expiration date in days
730
The target audience
Children
Dosage (volume) of the substance in the preparation
400 mg + 200 mg
Package weight, g
ten
Mode of application
:
Next tablets are taken orally, after meals. < br> < br> Adults: 1 tablet 3 times a day.
The maximum daily dose is 3 tablets.
< br> Children over 12 years old (body weight over 40 kg): 1 tablet 2 times a day. < br> < br> Duration of treatment is not more than 3 days as an antipyretic agent and not more than 5 days as an anesthetic. < br> < br> Continuation of treatment with the drug is possible only after consulting a doctor.
Pharmaco-therapeutic group
:
Combined analgesic (NSAIDs + non-narcotic analgesic)
Information on technical characteristics, delivery set, country of manufacture