Natamycin | Pimafucin vaginal suppositories 100 mg, 3 pcs.

Latin name

Pimafucin

Packing

3 pcs

Pharmacological action

Pimafucin - fungicidal, antifungal.

Pharmacodynamics

Natamycin irreversibly binds to the sterols of the cell membranes of fungi, disrupting the integrity and function, which leads to the death of microorganisms.

Most pathogenic yeasts, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. Primary resistance to natamycin is not found in clinical practice.

Pharmacokinetics

Natamycin has only local action, not absorbed from the digestive tract, through the skin and mucous membranes.

Indications

Vaginitis, vulvitis, vulvovaginitis, caused mainly by Candida fungi.

Contraindications

Hypersensitivity to the components of the drug.

Use during pregnancy and lactation

Pimafucin may be used during pregnancy and lactation, if indicated.

Composition

1 suppository contains:

Active ingredient: natamycin 100 mg excipients : cetyl alcohol - 690 mg solid fat - 700 mg sorbitol - 460 mg polysorbate 80 - 460 mg sodium bicarbonate - 69 mg adipic acid - 64 mg.

Dosage and administration of

For vaginitis, vulvitis, vulvovaginitis - 1 suppository for 3-6 days. The suppository is injected into the vagina in the prone position, as deep as possible, 1 time per day at night. With the persistent course of vaginitis caused by Candida albicans, Pimafucin is additionally prescribed in the form of tablets for oral administration (1 tablet 4 times a day for 10–20 days) to sanitize the focus of candidal infection in the intestines. For the treatment of candidiasis of the genital organs of a partner, Pimafucin in the form of a cream is used. The duration of treatment is set individually. After the symptoms disappear, it is recommended to continue treatment for a few more days.

Side effects

From the gastrointestinal tract: in some cases, when using enteric tablets, especially in the early days of treatment, nausea and diarrhea are possible, usually resolving on their own.

Local reactions: possible slight irritation, burning sensation (when applying cream, vaginal suppositories).

Overdose

There have been no reports of an overdose of Pimafucine to date. Prolonged use of Pimafucine does not adversely affect the skin or mucous membranes and systemic effects are virtually eliminated. Accidental intake of a large amount of the drug should not cause any toxic effect, since there is no absorption from the intestine.

Storage conditions

At a temperature not exceeding 25 РC.

Shelf life

2 years

Deystvuyushtee substance

Natamycin

Prescription conditions from

pharmacies Without prescription

dosage form

vaginal suppositories

Possible product names

Pimafucin supp vagin 100mg х 3

PIMAFUCIN 0.1 N3 SUPP

PIMAFUCIN 0.1 N3 SUPP VAG

Pimafucin 100mg srdlpc 100mg 3rdmfs. No. 3 SUPP.

Temmler Italia S.R.L., the Netherlands