Natamycin vaginal suppositories 100mg, No. 3

• Vaginitis

• vulvitis

• vulvomagnets caused by fungi of the genus Candida.

Route of administration - for vaginal use

Suppositories, previously released from the contour packaging, are introduced into the vagina while in the supine position as deep as possible 1 time per day at night.

Dosage

For candidal vaginitis, vulvitis, vulvovaginitis: intravaginally, one suppository for 3-6 days.

The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days. During menstruation, the use of suppositories is interrupted.

With a persistent course of vaginitis caused by Candida albicans, natamycin is additionally prescribed in the form of tablets for oral administration: 1 tablet 4 times a day for 10-20 days to sanitize the focus of candidal infection in the intestine.

Active substance : natamycin (in terms of 100% substance) - 100 mg:

Excipients : macrogol glnceryl hydroxystearate - 75 mg, colloidal silicon dioxide - 20 mg. solid fat (Supiocyr AM) up to 1500 mg.

• Hypersensitivity to the components of the drug.

Carefully:

No special precautions are required when using Natamicia.

Trade name of the drug

Natamycin

International non-proprietary name

Natamycin

Dosage form

vaginal suppositories

Composition

Active substance : natamycin (in terms of 100% substance) - 100 mg:

Excipients : macrogol glnceryl hydroxystearate - 75 mg, colloidal silicon dioxide - 20 mg. solid fat (Supiocyr AM) up to 1500 mg.

Description

Torpedo-shaped suppositories from light yellow to light brown. The longitudinal section must be free of foreign inclusions. The presence of an air rod or a funnel-shaped recess is allowed.

Pharmacotherapeutic group

Antifungal agent

ATX code

G01AA02

Pharmacodynamics:

Mechanism of action

Natamicia is an antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. It binds to the rocks of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms.

Active against most pathogenic yeast-like fungi (especially Candida albicans). yeast (Tontlopsis and Rhodolorula) and other pathogenic fungi (Aspergillus Penicillium). Less active against dermatophytes (Trichophyton Microsporuin Epidennophvton).

In vitro sensitivity

It does not affect in vitro gram-positive and gram-negative bacteria.

Resistance

Resistance to natamycin does not occur in clinical practice.

Pharmacokinetics:

Natamycin does not have a systemic effect, since it is practically not absorbed through intact skin and intact mucous membranes.

Indications:

• Vaginitis

• vulvitis

• vulvomagnets caused by fungi of the genus Candida.

Contraindications:

• Hypersensitivity to the components of the drug.

Carefully:

No special precautions are required when using Natamicia.

Pregnancy and lactation:

It is possible to use the drug in pregnant women and during lactation.

Method of administration and dosage:

Route of administration - for vaginal use

Suppositories, previously released from the contour packaging, are introduced into the vagina while in the supine position as deep as possible 1 time per day at night.

Dosage

For candidal vaginitis, vulvitis, vulvovaginitis: intravaginally, one suppository for 3-6 days.

The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days. During menstruation, the use of suppositories is interrupted.

With a persistent course of vaginitis caused by Candida albicans, natamycin is additionally prescribed in the form of tablets for oral administration: 1 tablet 4 times a day for 10-20 days to sanitize the focus of candidal infection in the intestine.

Side effects:

When applied topically, slight irritation and burning sensation at the injection site is possible.

Overdose:

Currently, no cases of drug overdose have been reported.

Interaction:

The drug interaction of Natamycin with other drugs has not been described.

Special instructions:

With vaginal application by the action of body temperature, the suppositories turn into a foamy mass, which contributes to the uniform distribution of natampcin over the vaginal mucosa.

During the treatment period, there is no need to exclude sexual intercourse, however, it is recommended to examine the sexual partners and. in case of revealing a candidal lesion, conduct a course of treatment with natamycin. During the period of treatment, barrier methods of contraception should be used.

Impact on the ability to drive vehicles. Wed and fur .:

The use of the drug Natamycin ns affects the ability to drive vehicles and mechanisms.

Release form / dosage:

Vaginal suppositories 100 mg.

Packaging:

3 vaginal suppositories in a blister strip made of PVC / PE.

1 blister strip along with instructions for use in a cardboard box.

Storage conditions:

In a place protected from moisture and light at a temperature not exceeding 25 ? C. Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date stated on the package.

Vacation conditions

Without recipe.