Nanotropil Novo tablets 100mg, No. 30

Х Diseases of the central nervous system of various origins, especially those associated with metabolic disorders in the brain, intoxication (in particular, in post-traumatic conditions), accompanied by a deterioration in intellectual and mnestic functions, a decrease in motor activity;

Х Neurotic conditions, manifested by lethargy, increased exhaustion, decreased psychomotor activity, impaired attention, memory impairment;

Х Violations of the learning process;

Х Psychoorganic syndromes, manifested by intellectual-mnestic disorders and apathetic-abulic phenomena, as well as sluggish states in schizophrenia;

Х Convulsive states;

Х Obesity (alimentary-constitutional genesis);

Х Prevention of hypoxia, increased resistance to stress, correction of the functional state of the body in extreme conditions of professional activity in order to prevent the development of fatigue and to increase mental and physical performance, correction of the daily biorhythm, inversion of the sleep-wake cycle;

Х Chronic alcoholism (in order to reduce intellectual and mnestic disorders).

Nanotropil tablets are newly taken orally immediately after a meal.

The dose of fonturacetam and the course of treatment are determined by the attending physician in accordance with the characteristics of the patient's condition.

Recommended single doses can vary from 100 to 250 mg (average - 150 mg), daily doses - from 200 to 300 mg (average 250 mg).

The maximum allowable dose should not be higher than 750 mg / day.

A daily dose of less than 100 mg should be taken at one time in the morning; it is recommended that a dose of more than 100 mg be divided into two doses.

The duration of therapy can be from 14 to 90 days, on average - 30 days.

One month after the completion of treatment, if necessary, it is possible to prescribe a second course.

For the treatment of alimentary-constitutional obesity and to enhance performance, the drug is recommended to be used in a dose of 100-200 mg 1 time / day (in the morning).

The duration of treatment for primary obesity is 30-60 days, with the aim of increasing efficiency - 14 days, and for athletes - 3 days.

You should not take Nanotropil again later than 15 hours.

Composition for one tablet:

Package quantity - 30 tab.

Active ingredient: Phenylpiracetam 100.00 mg

Chemical formula: C12H14N2O2

Excipients:

• Povidone K-17 15.20 mg

• Microcrystalline cellulose 167.00 mg

• Sodium carboxymethyl starch 15.10 mg

• Magnesium stearate 2.70 mg

• Individual intolerance;

• Children under 18 years of age (safety and efficacy of the drug have not been established).

• With caution Patients with severe organic lesions of the liver and kidneys, severe arterial hypertension, severe atherosclerosis, previous panic attacks, acute psychotic conditions proceeding with psychomotor agitation - due to the possibility of exacerbation of anxiety, panic, hallucinations and delusions, as well as patients prone to to allergic reactions to nootropic drugs of the pyrrolidone group. Application during pregnancy and during breastfeeding Should not be prescribed during pregnancy and lactation due to the lack of data from clinical studies.

Pharmacodynamics

A nootropic drug with a pronounced antiamnestic effect has a direct activating effect on the integrative activity of the brain, promotes memory consolidation, improves concentration and mental activity, facilitates the learning process, increases the speed of information transfer between the cerebral hemispheres and the resistance of brain tissue to toxic effects, possesses anticonvulsant action and anxiolytic activity. It has a positive effect on metabolic processes, stimulates redox processes, increases the energy potential of the body by utilizing glucose. Increases the content of norepinephrine, dopamine and serotonin in the brain, does not affect the level of GABA, does not bind to GABAA and GABAB receptors,does not have a noticeable effect on the spontaneous bioelectric activity of the brain. It does not affect respiration and the cardiovascular system, exhibits an unexpressed diuretic effect, and has anorexigenic activity when used as a course. The stimulating effect is manifested in the ability to have a moderately pronounced effect, which manifests itself in relation to motor reactions, an increase in physical performance, as well as a weakening of the severity of the hypnotic effect of ethanol and hexobarbital. The psychostimulating effect prevails in the ideational sphere. The moderate psychostimulating effect of the drug is combined with anxiolytic activity. It has some analgesic effect, increasing the pain threshold.The adaptogenic effect is manifested in an increase in the body's resistance to stress under conditions of excessive mental and physical stress, with fatigue, hypokinesia and immobilization, at low temperatures. Against the background of taking the drug, an improvement in vision was noted, which manifests itself in an increase in acuity, brightness and visual fields. Improves blood flow to the lower extremities. Stimulates the production of antibodies in response to the introduction of an antigen, which indicates immunostimulating properties, but at the same time does not contribute to the development of immediate hypersensitivity and does not change the allergic inflammatory reaction of the skin caused by the introduction of a foreign protein. With course use, drug dependence, tolerance, 'withdrawal syndrome' do not develop. The effect is manifested in a single dose, which is important when using the drug in extreme conditions.Does not possess teratogenic, mutagenic, carcinogenic and embryotoxic properties. It has low toxicity, the lethal dose in an acute experiment is 800 mg / kg.

Pharmokinetics

It is rapidly absorbed, penetrates into various organs and tissues, easily passes through the blood-brain barrier. Absolute oral bioavailability is 100%. The maximum concentration in the blood (Tmax) is reached after 1 hour, the half-life (T 1/2) is 3-5 hours. It is not metabolized in the body. It is excreted unchanged: approximately 40% - with urine and 60% - with bile and sweat.

Overdose

Overdose cases were not observed. Treatment: symptomatic therapy.

Side effects

Insomnia (if the drug is taken later than 15 hours). In some patients, in the first 1-3 days of admission, psychomotor agitation, hyperemia of the skin, a feeling of warmth, an increase in blood pressure are possible

Special conditions

With excessive psychoemotional exhaustion against the background of stress and fatigue, chronic insomnia, a single dose of the drug on the first day can cause a sharp need for sleep. Such patients on an outpatient basis should be advised to start the course of taking the drug on non-working days. Influence on the ability to drive vehicles, mechanisms Care should be taken when driving vehicles and mechanisms, especially in the first days of admission, given the possible occurrence of drowsiness (see 'Special instructions').

Drug interactions

Phenylpiracetam can enhance the effect of drugs that stimulate the central nervous system and nootropic drugs. The drug exhibits a pronounced antagonism to the cataleptic effect of neuroleptics, and also weakens the severity of the hypnotic effect of ethanol and hexobarbital.

Manufacturer: Valenta-Intellect (JSC 'Obninskaya KhFK')

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