Mucosat injection solution 100mg / ml, 2ml No. 5

Degenerative-dystrophic diseases of the joints and spine:

- osteoarthritis of the peripheral joints;

- intervertebral osteochondrosis and osteoarthritis.

To accelerate the formation of callus in fractures.

MucosatЃ is administered intramuscularly in a dose of 1 ml every other day. With good tolerance, the dose is increased to 2 ml, starting with the fourth injection. The course of treatment is 25-30 injections. If necessary, it is possible to conduct repeated courses after 6 months.

For the formation of callus, the course of treatment is 3-4 weeks (10-14 injections every other day).

Active substance:

chondroitin sodium sulfate 100 mg

Excipients:

benzyl alcohol 9 mg; water for injection up to 1 ml.

• Hypersensitivity to the drug,

• bleeding tendency

• thrombophlebitis.

pharmachologic effect

The drug has a chondroprotective, stimulating regeneration of cartilage tissue, anti-inflammatory effect. Participates in the construction of the basic substance of cartilage and bone tissue, improves phosphorus - calcium metabolism in cartilage tissue, inhibits enzymes that disrupt the structure and function of articular cartilage, inhibits the processes of degeneration of cartilage tissue. Stimulates the synthesis of proteoglycans, normalizes the metabolism of hyaline cartilage, promotes the regeneration of cartilaginous surfaces and articular sac. It prevents the compression of connective tissue, increases the production of synovial fluid and the mobility of the affected joints, reduces concomitant inflammation, soreness, and helps to reduce the need for NSAIDs. With degenerative changes in cartilage tissue, it is a means of replacement therapy.

A positive effect is observed already 2-3 weeks after the start of drug administration. The therapeutic effect lasts a long time (3-6 months) after the end of the course of treatment.

Pharmacokinetics:

Chondroitin sodium sulfate is readily absorbed after intramuscular administration. Already after 30 minutes, it is found in the blood in significant concentrations: the maximum concentration is reached after 1 hour, then its content gradually decreases within 2 days.

Chondroitin sodium sulfate accumulates mainly in cartilage tissue.

The synovium is not an obstacle to its penetration into the joint cavity. 15 minutes after the intramuscular injection of chondroitin, sodium sulfate is found in the synovial fluid, then it enters the articular cartilage, where its content reaches a maximum after 48 hours.

Indications for use

Degenerative-dystrophic diseases of the joints and spine:

- osteoarthritis of the peripheral joints;

- intervertebral osteochondrosis and osteoarthritis.

To accelerate the formation of callus in fractures.

Contraindications

Hypersensitivity to the drug, a tendency to bleeding, thrombophlebitis.

Application during pregnancy and lactation, as well as in children .

Currently, there are no data on the use of MucosatЃ during pregnancy and lactation, as well as in children.

Method of administration and dosage

MucosatЃ is administered intramuscularly in a dose of 1 ml every other day. With good tolerance, the dose is increased to 2 ml, starting with the fourth injection. The course of treatment is 25-30 injections. If necessary, it is possible to conduct repeated courses after 6 months.

For the formation of callus, the course of treatment is 3-4 weeks (10-14 injections every other day).

Side effect

Allergic reactions and hemorrhages at the injection site are possible. In these cases, the drug is canceled.

Interaction with other medicinal products

When undergoing a course of treatment with the drug 'MucosatЃ', one should be careful about the simultaneous use of direct anticoagulants. It is also possible to enhance the action of indirect anticoagulants, antiplatelet agents and fibrinolytics.