Mitrek 19g

DESCRIPTION

Mitrek (Mitrec) - suspension for intrauterine administration for the treatment of endometritis in cows. In appearance, the drug is a suspension of light yellow to yellow color.

COMPOSITION

One syringe of the drug as an active ingredient contains: cefapirin (in the form of benzathine salt) -500 mg and excipients: butylhydroxytoluene (ionol), benzyl alcohol, colloidal anhydrous silicon dioxide (Aerosil 300) and triglycerides of saturated fatty acids (miritol 318) - up to 19g.

PHARMACOLOGICAL PROPERTIES

Mitrek belongs to the antibacterial drugs of the cephalosporin group.

Cefapirin, which is part of the drug, has a wide spectrum of bactericidal action against Staphylococcus spp., Streptococcus pyogenes, Pasteurella spp., Proteus mirabilis, Fusobacterium spp., Escherichia coli, Klebsieila spp., Neissel'ia spp., Pseudomonosapp. , Salmonella spp., Shigella spp., Flaemophilus influenzae and other pathogenic microorganisms, mainly isolated in subacute and chronic forms of endometritis in cows.

The bactericidal effect of cefapirin is to inhibit the synthesis of the cell wall, which causes the destruction of the cytoplasmic membrane and the death of the bacterial cell.

The antibiotic is resistant to the action of the enzyme penicillinase and retains its activity under aerobic and anaerobic conditions.

After intrauterine administration of the drug Mitrek, cefapirin benzathine easily penetrates from the uterine cavity into the endometrium, where it remains in a bactericidal concentration for at least 24 hours. Cefapirin benzathine enters the systemic circulation in insignificant quantities, the maximum concentration of the antibiotic in the blood plasma 1-2 hours after administration is O, 11-0.44 Ојg / ml. The antibiotic is excreted from the body mainly in the urine in an unchanged form, and in the form of a metabolite - deacetylcephapirin.

According to the degree of impact on the body, Mitrek belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).

DOSAGE AND APPLICATION

Mitrek is used in cows for the treatment of subacute and chronic forms of endometritis of bacterial etiology, which usually occur 14 days after calving, as well as with latent forms of endometritis.

Mitrek is administered to cows in the uterine cavity at a dose of 19 g (contents of one syringe). For the treatment of subacute and chronic forms of endometritis, Mitrek is used no earlier than] 4 days after calving. If necessary, the treatment is repeated after 7-14 days at the same dose. Pre-administration of F2a prostaglandins 3-4 days before drug administration significantly increases the effectiveness of treatment and eliminates the need for repeated administration of the drug.

For the treatment of latent forms of endometritis, the drug is administered 6-24 hours after insemination.

Before the introduction of the drug, the external genital organs and the root of the tail are sanitized. If necessary, the uterine cavity is freed from inflammatory exudate. The syringe is connected to the catheter, a glove is put on the hand and the cervix is ​​rectally fixed, then the catheter is carefully inserted through the cervix into the uterine cavity and the contents of the syringe are squeezed out.

SPECIAL INSTRUCTIONS

When working with Mitrek, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines. People with hypersensitivity to the components of the drug should avoid direct contact with the drug.

Overdose symptoms: the drug has not been established.

The simultaneous use of the drug Mitrek and other drugs for intrauterine administration containing antibiotics is not allowed.

The peculiarities of the action during the first use and upon discontinuation of the drug were not revealed.

Violations of the timing of the use of the drug should be avoided, as this can lead to a decrease in therapeutic efficacy. If the next dose is missed, the drug must be administered as soon as possible in the same dose. You should not enter a double dose to compensate for the missed dose.

Slaughter of cows for meat is carried out no earlier than 24 hours after the last injection of the drug. Meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding carnivores.

CONTRAINDICATIONS

A contraindication to the use of the drug is an increased individual sensitivity to one of the components of the drug, including a history of cephalosporin and other beta-lactam antibiotics. The drug should not be used if microorganisms resistant to cephalosporins are isolated from a sick animal.

It is forbidden to use the drug for pregnant cows.

SIDE EFFECTS

When using the drug according to the instructions for use of the side. no phenomena and complications have been established. In case of an allergic reaction, the use of the drug is discontinued, antihistamines and symptomatic therapy are prescribed to the animal.

SHELF LIFE AND STORAGE

The shelf life of the drug, subject to storage conditions in the manufacturer's closed packaging, is 3 years from the date of production. It is necessary to open the medicinal product immediately before its use; after opening the package, the drug cannot be stored.

Store the medicinal product in the manufacturer's sealed packaging, separately from food and feed, in a place protected from direct sunlight, at a temperature of 2 В° C to 25 В° C.

PACKAGING

Mitrek is produced packaged in 19g in polymer syringes sealed with a protective cap, which are packed together with catheters for intrauterine administration, disposable gloves for rectal fixation of the cervix and instructions for use.

Specifications

KolVUP

thirty

Manufacturer

Nita-Farm

Temperature regime

from +2 to +25

Teaser

for the treatment of endometritis in cows