Minocycline | Minolexin capsules 100 mg, 20 pcs.

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SKU
BID470357
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Latin name

MINOLEXIN
Latin name

MINOLEXIN

Release form

Hard gelatin capsules, No. 2, with a body and a white lid, the contents of the capsules are yellow powder.



packaging 20 pcs

Pharmacological action of

Minolexin is a semi-synthetic antibiotic from the tetracycline group. It has a bacteriostatic effect on cells of sensitive strains of microorganisms due to reversible inhibition of protein synthesis at the level of 30S ribosome subunits. It has a wide range of antibacterial activity.

Sensitivity of microorganisms: Some of the microorganisms listed below have shown resistance to minocycline, therefore laboratory tests are recommended before use. sensitivity study. Antibiotics of the tetracycline group are not recommended for the treatment of streptococcal and staphylococcal infections, unless

sensitivity of microorganisms to minocycline is shown.

Gram-positive aerobic: Bacillus anthracis, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae.

Gram-negative aerobic: Bartonella bacilliformis, Brucella species, Calymmatobacterium granulomatis, Campylobacterfetils, Francisella tularensis, Haemophilus ducreyi, Vibrio cholerae, Yersinia pestis.

Indications

Minolexin is used to treat the following diseases, provided pathogenic microorganisms are sensitive: Acne

Skin infections

Spotted fever, typhoid fever, typhoid fever, respiratory tract disease Ornithosis

Trachoma (infectious keratoconjunctivitis)

Conjunctivitis with inclusions (paratrachoma)

Non-nonococcal urethritis, cervical and posterior canal infections Adult ode

Cyclic fever

Chancroid

Plague

Tularemia

Cholera

Brucellosis

Bartonellosis

Inguinal granuloma

Syphilis

Gonorrhea (Gonorrhea non-venereal syphilis)

Listeriosis

Anthrax

Angina Vincent

Actinomycosis.

In the case of acute intestinal amebiasis, minocycline may be used as a supplement to amoebicidal drugs.

In severe acne. minocycline can be used as adjunctive therapy.

Oral administration of minocycline is indicated for asymptomatic carriage of Neisseria mepigitidis to eradicate meningococci from the nasopharynx.

Contraindications

Hypersensitivity to minocycline, tetracyclines and other components of the

preparation Porphyria

Severe hepatic and renal failure

Leukopenia

Pregnancy breastfeeding

Systemic lupus erythematosus

Children under 8 years of age have been diagnosed with acute illness

malabsorption Precautions: impaired liver and kidney function, concomitant use with hepatotoxic drugs.

Composition

Active ingredient: minocycline hydrochloride dihydrate (in terms of minocycline) 100 mg

Excipients: microcrystalline cellulose, low molecular weight povidone, potato starch, magnesium stearate, lactose monohydrate.

Dosage and Administration

Inside, after meals. It is recommended to drink plenty of fluids (can be milk) for. reduce the risk of irritation and ulceration in the esophagus.

The initial dose of Minolexin is 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), then take 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours (twice a day) .

The maximum daily dose should not exceed 400 mg.

Urogenital and anogenital infections caused by chlamydia and ureaplasma: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours for 7-10 days.

Inflammatory diseases of the pelvic organs in women in the acute stage: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours, sometimes in combination with cephalosporins.

Primary syphilis in patients. with hypersensitivity to penicillins: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) twice a day for 10 to 15 days.

Gonorrhea: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) twice a day for 4-5 days, or once 300 mg.

Uncomplicated gonococcal infections (excluding urethritis and anorectal infections) in men: initial dose - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), maintenance dose - 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours for at least 4 days, followed by a microbiological assessment of recovery 2-3 days after stopping the drug.

Uncomplicated gonococcal urethritis in men: 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours for 5 days.

Acne: 50 mg (1 capsule of 50 mg) per day, for a long course of 6-12 weeks.

Side effects of the

From the digestive system: anorexia, nausea, vomiting, diarrhea, dyspepsia, stomatitis, glossitis, dysphagia, hypoplasia of tooth enamel, enterocolitis, pseudomembranous colitis, inflammatory and pancreatic inflammation) cavity and anogenital region, hyperbilirubinemia, cholestasis, an increase in the content of “liver” enzymes, liver failure, including terminal, hepatitis, including autoimmune.

From the genitourinary system: candida vulvovaginitis, interstitial nephritis, dose-dependent increase in urea in plasma.

From the skin: baldness, erythema nodosum, nail pigmentation, itching, toxic epidermal necrosis, vasculitis, maculopapular and erythematous rash, Stevens-Johnson syndrome, exfoliative dermatitis, balanitis.

From the respiratory tract: shortness of breath, bronchospasm, exacerbation of asthma, pneumonia.

From the musculoskeletal system: arthralgia, arthritis, limited mobility and swelling of the joints, discoloration of bone tissue, muscle pain (myalgia).

Allergic reactions: urticaria, angioedema, polyarthralgia, anaphylactic reactions (including shock), anaphylactoid purpura (Purple by Schoenlein Genoch), pericarditis, exacerbations of systemic lupus erythematosus, lung infiltration, accompanied by eosinophilia.

From the hemopoietic organs: agranulocytosis, hemolytic anemia, tr6mbocytopenia, leukopenia, neutrocytopenia, pancytopenia, eosinopenia, eosiophilia.

From the central nervous system: cramps, dizziness, numbness (including limbs), lethargy, vertigo, increased intracranial pressure in adults, headaches.

From the sensory organs: tinnitus and hearing impairment.

From the side of metabolism: Thyroid gland: an isolated case of a malignant neoplasm, discoloration (according to the results of patho-morphological studies), impaired function.

Others: Change in color of the oral cavity (tongue, gum, palate), change in color of tooth enamel, fever, discharge color (for example, sweat).

Drug Interactions

The tetracycline group of drugs reduces the prothrombin activity of blood plasma, which may necessitate a reduction in the doses of anticoagulants in patients undergoing anticoagulant therapy.

Due to the fact that bacteriostatic drugs affect the bactericidal effect of penicillins, the simultaneous administration of penicillin and tetracycline groups should be avoided.

The absorption of tetracyclines is impaired when taken with antacids containing aluminum, calcium, magnesium or iron-containing drugs, which can lead to a decrease in the effectiveness of antibiotic therapy.

There have been cases of terminal renal toxicity while taking methoxyfruran and drugs of the

group of tetracyclines.

The simultaneous use of antibiotics of the tetracycline group and oral contraceptives can lead to a decrease in the effectiveness of contraception.

Avoid isotretinoin immediately before, simultaneously and immediately after taking minocycline, since both drugs can cause a benign increase in intracranial pressure.

Concomitant use of tetracycline drugs with ergot alkaloids and their derivatives increases the risk of ergotism.

Overdose of

Symptoms: Dizziness, nausea, and vomiting are most commonly observed.

Treatment: The selective antidote for minocycline is currently unknown. In case of an overdose, it is necessary to stop taking the drug, provide symptomatic treatment and supportive therapy. Hemo- and peritoneal dialysis remove minocycline in small quantities.

Storage Conditions

In a place protected from moisture and light, at temperatures. is not higher than 25 РC. Keep out of reach of children.

Expiration

2 years.

Active ingredient

Minocycline

Pharmacy terms Pharmacies

In retseptu

lekarstvennaja form

kapsul

Prescription

For children over 8 years of age, Adults as prescribed by the doctor, Children as prescribed by the doctor

Indications

Indications

From inflammations of the female genital organs, From infections of the bile , From infectious diseases, From respiratory infections, From skin infections, Bronchitis, From prostatitis, From pneumonia, From cholecystitis, Acne, From sore throat

АВВА РУС, Russia

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