Milprazone for dogs weighing more than 5 kg 2 tablets 12.5 mg

DESCRIPTION

Milprazone is a broad-spectrum anthelmintic drug for dogs weighing more than 5 kg. Dosage form: tablets for oral administration. In appearance, they are round, biconvex tablets with a yellowish-white meat taste with brown blotches.

COMPOSITION

The drug in 1 tablet contains: milbemycin oxime - 12.5 mg, praziquantel - 125 mg and excipients: microcrystalline cellulose - 115.40 mg, lactose monohydrate - 195.50 mg, povidone - 20 mg, croscarmellose sodium - 50 mg, colloidal silicon colloidal - 7.60 mg anhydrous , magnesium stearate - 12mg, meat flavor (Aroma Meat Flavor 10022) - 90mg, dry yeast - 32mg.

PHARMACOLOGICAL PROPERTIES

Milprazone tablets for dogs belong to the group of combined anthelmintic drugs with nematodicidal and cestodicidal action.

The active ingredients included in the preparation provide its wide spectrum of anthelmintic action.

Milbemycin oxime is a macrocyclic lactone obtained as a result of the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus, is active against larvae and imago of nematodes parasitizing in the gastrointestinal tract of dogs, as well as larvae of Dirofilaria immitis.

The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chlorine ions (Cl-), which leads to overpolarization of the membranes of the cells of the nervous and muscle tissue, paralysis and death of the parasite. The maximum concentration of milbemycin oxime in the blood plasma of dogs is reached within 2-4 hours, the bioavailability is about 80%. The compound is excreted from the body mainly unchanged.

Praziquantel is an acylated pyrazinisoquinoline derivative that has a pronounced effect against cestodes and nematodes. Increasing the permeability of the parasite's cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and destruction of the tegument, which leads to the death of the parasite and promotes its excretion from the animal's body. The maximum plasma concentration of praziquantel in dogs is reached after 1-4 hours. The compound undergoes rapid and almost complete biotransformation in the liver. The level of binding in plasma is about 80%, it is excreted from the body within 2 days mainly in the urine.

Milprazone tablets for dogs, according to the degree of impact on the body, are classified as low-hazard substances (hazard class 4 according to GOST 12.1.007-76), in recommended doses they do not have a sensitizing, embryotoxic and teratogenic effect, are well tolerated by dogs of different breeds and ages. The drug is toxic to bees, as well as fish and other aquatic organisms.

Milprazone tablets for dogs are compatible with selamectin, there is no information on the compatibility of the drug with other macrocyclic lactones.

INDICATIONS

MilprazoneВ® tablets for dogs are prescribed for therapeutic and prophylactic purposes in case of nematodes, cestodes and associative nematodes-cestodes infestations caused by helminths of the following types: cestodes - Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp .; nematodes - Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Thelazia callipaeda; Angiostrongylus vasorum (reduces the intensity of infection), Crenosoma vulpis (reduces the intensity of infection), Dirofilaria immitis (prevention of the disease).

APPLICATION

Milprazone tablets for dogs are used once during feeding with a small amount of food or injected forcibly onto the root of the tongue after feeding in a minimum therapeutic dose of 0.5 mg milbemycin oxime and 5 mg praziquantel per 1 kg of animal weight, based on:

Animal weight For puppies and small dogs weighing up to 5kg (oval tablets containing milbemycin oxime - 2.5mg and praziquantel - 25mg) For dogs weighing over 5kg (round tablets containing milbemycin oxime - 12.5mg and praziquantel - 125mg)

0.5-1kg ? pills -

1-5kg 1 tablet -

5-10kg 2 tablets 1 tablet

10-25kg - 1 tablet

25-50kg - 2 tablets

50-75kg - 3 tablets

The unused half of the tablet can be placed in a blister and stored until the next deworming, but no more than 6 months after opening the package.

A preliminary fasting diet and the use of laxatives before deworming are not required.

For deworming dogs with infestation caused by Angiostrongylus vasorum, Milprazone tablets for dogs are used for therapeutic purposes four times with an interval of 7 days, for prophylaxis - every 4 weeks at a therapeutic dose.

For deworming dogs with an invasion caused by Thelazia callipaeda, the drug is used twice with an interval of 7 days.

In order to prevent dirofilariasis in regions unfavorable for the disease, the drug is used in the spring-summer-autumn period: before the start of flight of mosquitoes and mosquitoes (carriers of the pathogen D. immitis) once, then once a month and the last time in the season 1 month after the end of the flight insects. Before deworming, you should consult a veterinarian to exclude the presence of microfilariae in the animal's blood.

When carrying out deworming, you should adhere to the time recommended by the instruction. In case of skipping the next treatment, the use of the drug is resumed in the same dose and according to the same scheme.

CONTRAINDICATIONS

Contraindication to use is the individual hypersensitivity of the animal to the components of the drug (including a history), pronounced impaired renal and liver function. Depleted and sick with infectious diseases animals are not subject to deworming.

Do not use the drug in puppies younger than 2 weeks of age and weighing less than 0.5 kg. Deworming of lactating and pregnant bitches, collie, bobtail and sheltie puppies, if necessary, is carried out under the supervision of a veterinarian.

The drug is not intended for use in productive animals.

OVERDOSE

In case of an overdose of the drug, some dogs may experience depression, drooling, muscle paresis, trembling and / or a wobbly gait. These symptoms disappear spontaneously during the day, if necessary, the animal is prescribed symptomatic therapy.

SIDE EFFECTS

As a rule, side effects and complications are not observed when using the drug according to this instruction. Some animals may experience lethargy, ataxia, muscle tremors, vomiting and / or diarrhea; in these cases, the drug is discontinued and the animal is prescribed symptomatic therapy.

PRECAUTIONS

When working with Milprazone tablets for dogs, it is necessary to follow the general rules of personal hygiene and safety precautions provided when working with medicinal products. People with hypersensitivity to the components of the drug should avoid direct contact with Milprazone tablets for dogs.

It is forbidden to use empty packaging from under the medicinal product for household purposes, it must be disposed of with household waste.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of running water.In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (with you have instructions for use of the drug or a label) ...

STORAGE

Store the drug in a closed manufacturer's packaging in a dry place protected from direct sunlight, separately from food and feed, at a temperature of 5 В° C to 25 В° C. The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 2 years from the date of manufacture.

PACKING

The drug is released packaged in 2 tablets in blisters, packed in cardboard boxes.

Specifications

KolVUP

1

Manufacturer

KRKA

Temperature regime

from +5 to +25

Teaser

broad-spectrum anthelmintic drug for dogs weighing more than 5kg with meat flavor