Milprazone for cats weighing up to 2 kg 2 tablets 4 mg

DESCRIPTION

Milprazone is an anthelmintic drug for kittens and cats weighing up to 2 kg. Dosage form: tablets for oral administration. In appearance, they are brown-yellow oval biconvex tablets with a taste of meat, film-coated, with a line on one side

COMPOSITION

The drug contains: milbemycin oxime - 4 mg / tab. And praziquantel - 10mg / tab. and excipients: microcrystalline cellulose - 32.98 mg, lactose monohydrate - 75.37 mg, povidone - 0.75 mg, croscarmellose sodium - 5.50 mg, colloidal anhydrous silicon - 0.90 mg, magnesium stearate - 2.50 mg, White opadray - 3 , 20mg, meat flavor - 0.40mg, dry yeast - 0.20mg, iron oxide yellow E172 - 0.20mg

PHARMACOLOGICAL PROPERTIES

Milprazone tablets for cats belong to the group of combined anthelmintic drugs with nematodicidal and cestodicidal action.

The active ingredients included in the preparation provide its wide spectrum of anthelmintic action.

Milbemycin oxime is a macrocyclic lactone obtained as a result of the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus, active against larvae and imago of nematodes parasitizing in the gastrointestinal tract of cats, as well as larvae of the nematode Dirofilaria immitis.

The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chlorine ions (Cl-), which leads to overpolarization of the membranes of the cells of the nervous and muscle tissue, paralysis and death of the parasite. After oral administration of the drug, the maximum concentration of milbemycin oxime in the blood plasma of cats is reached after 2 hours, the compound is excreted from the body mainly unchanged, the half-life is about 13 hours.

Praziquantel is an acylated pyrazinisoquinoline derivative that has a pronounced effect against cestodes and nematodes. Increasing the permeability of the parasite's cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and destruction of the tegument, which leads to the death of the parasite and promotes its excretion from the animal's body. After oral administration of the drug, the maximum concentration of praziquantel in the blood plasma of cats is reached after 1 hour, the compound is excreted from the body mainly in the form of inactive metabolites in the urine, the half-life is about 3 hours.

Milprazone tablets for cats, according to the degree of impact on the body, are classified as moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses they do not have a sensitizing, embryotoxic and teratogenic effect, are well tolerated by cats of different breeds and ages. The drug is toxic to bees, as well as fish and other aquatic organisms.

Milprazone tablets for cats are compatible with selamectin, there is no information on the compatibility of the drug with other macrocyclic lactones.

INDICATIONS

Milprazone tablets for cats are prescribed for therapeutic and prophylactic purposes for nematodes, cestodes and associative nematodes-cestodes caused by both larval forms and sexually mature cestodes and nematodes of the following types: cestodes - Dipylidium caninum, Taloceniacoccus; Echinococcus; nematodes - Ancylostoma tubaeforme, Toxocara cati, Dirofilaria immitis (disease prevention).

APPLICATION

The drug is administered to cats once during feeding with a small amount of food or injected forcibly onto the root of the tongue after feeding in a minimum therapeutic dose of 2 mg milbemycin oxime and 5 mg praziquantel per 1 kg of animal weight, based on:

Animal weight For kittens and cats weighing more than 2kg (brown-yellow tablets containing 4mg milbemycin oxime and 10mg praziquantel) For cats over 2kg (brown-red tablets containing 16mg milbemycin oxime and 40mg praziquantel)

0.5-1kg ? pills -

1-2kg 1 tablet -

2-4kg - ? pills

4-8kg - 1 tablet

8-12kg - 1+? pills

A preliminary fasting diet and the use of laxatives before deworming are not required.

For therapeutic purposes, cats are dewormed according to indications, for prophylactic purposes - on a quarterly basis, as well as before each vaccination and mating in a therapeutic dose. A single dose of deworming drug protects cats from Dirofilaria immitis infection for up to one month. For the subsequent prevention of dirofilariasis, it is advisable to use a drug containing one active ingredient milbemycin oxime.

The unused half of the tablet can be placed in a blister and stored until the next deworming, but no more than 6 months after opening the package.

When carrying out deworming, you should adhere to the time recommended by the instruction. In case of skipping the next treatment, the use of the drug is resumed in the same dose and according to the same scheme.

SPECIAL INSTRUCTIONS

Deworming of pregnant and lactating cats, if necessary, is carried out under the supervision of a veterinarian.

CONTRAINDICATIONS

Contraindication to use is the individual hypersensitivity of the animal to the components of the drug (including a history), pronounced impaired renal and liver function. Do not use the drug in kittens younger than 6 weeks of age and weighing less than 0.5 kg. Depleted and sick with infectious diseases animals are not subject to deworming.

The drug is not intended for use in productive animals.

OVERDOSE

Overdose in cats may cause lethargy, ataxia, muscle tremors, vomiting and / or diarrhea. Symptoms disappear spontaneously within a day, if necessary, the animal is prescribed symptomatic therapy.

SIDE EFFECTS

As a rule, side effects and complications are not observed when using the drug according to this instruction.

In rare cases, more often in kittens, lethargy, ataxia, muscle tremors, vomiting and / or diarrhea may occur. In this case, symptomatic therapy is prescribed to the animal.

PRECAUTIONS

When working with Milprazone tablets for cats, it is necessary to follow the general rules of personal hygiene and safety measures provided for when working with medications. People with hypersensitivity to the components of the drug should avoid direct contact with Milprazone tablets for cats.

It is forbidden to use empty packaging from under the medicinal product for household purposes, it must be disposed of with household waste.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of running water. In case of allergic reactions or in case of accidental ingestion of the drug into the human body, you should immediately contact a medical institution (with you have instructions for using the drug or a label).

SHELF LIFE AND STORAGE

Store the drug in a closed manufacturer's packaging in a dry place protected from direct sunlight, separately from food and feed, at a temperature of 5 В° C to 25 В° C. The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 2 years from the date of manufacture.

PACKAGING

The drug is released packaged in 2 tablets in blisters, packed in cardboard boxes.

Specifications

Bonus points

0

KolVUP

1

Manufacturer

KRKA

Temperature regime

from +5 to +25

Teaser

anthelmintic drug for kittens and cats weighing up to 2kg

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