Milbemax anthelmintic for adult dogs 2 tablets

DESCRIPTION

Milbemax is an anthelmintic drug for adult dogs. In appearance, the drug is a white, elongated tablet with beveled edges and a transverse notch on one side.

COMPOSITION

As active substances, it contains milbemycin oxime - 12.5 mg and praziquantel - 125 mg / tab. As auxiliary components it contains: microcrystalline cellulose - 20%, sodium croscarmellose - 3%, povidone - 1.5%, lactose monohydrate - 51.5%, colloidal silicon and magnesium stearate - 2%.

PHARMACOLOGICAL PROPERTIES

Milbemax tablets for dogs are a combined anthelmintic drug of nematodicidal and cestodicidal action.

Milbemycin oxime, which is part of the drug, belongs to the group of macrocyclic lactones released as a result of the enzymatic activity of Streptomyces hygroscopkus var. aureolacrimosus, is active against larvae and adults of nematodes parasitizing in the gastrointestinal tract of dogs, as well as larvae of the nematode Dirofilaria immitis. The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chloride ions (CI), which leads to overpolarization of the membranes of nerve and muscle tissue cells, paralysis and death of the parasite. The maximum concentration of milbemycin oxime in the blood plasma of dogs is reached within 2-4 hours, the bioavailability is about 80%. The compound is excreted from the body mainly unchanged. Praziquantel is an acylated pyrazine isoquinoline derivative, has a pronounced effect against cestodes and nematodes. By increasing the permeability of the parasite's cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and destruction of the tegument, which leads to the death of the parasite and promotes its excretion from the animal's body. The maximum plasma concentration of praziquantel in dogs is reached after 1-4 hours. The compound undergoes rapid and almost complete biotransformation in the liver. The level of binding in plasma is about 80%, it is excreted from the body within 2 days mainly in the urine. The maximum plasma concentration of praziquantel in dogs is reached after 1-4 hours. The compound undergoes rapid and almost complete biotransformation in the liver. The level of binding in plasma is about 80%, it is excreted from the body within 2 days mainly in the urine. The maximum plasma concentration of praziquantel in dogs is reached after 1-4 hours. The compound undergoes rapid and almost complete biotransformation in the liver. The level of binding in plasma is about 80%, it is excreted from the body within 2 days mainly in the urine.

Milbemax tablets for dogs, according to the degree of impact on the body, are classified as moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses they do not have a sensitizing, embryotoxic and teratogenic effect, are toxic to fish and other aquatic organisms.

INDICATIONS

Milbemax tablets for dogs are prescribed for therapeutic and prophylactic purposes for nematodes, cestodes and mixed nematodes-cestodes infections caused by helminths of the following types: cestodes - Dipylidium caninum, Taenia spp., Echinocoaus multilocularis, Mesocestoides spp .; nematodes - Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Renosoma vulpis (reduces the intensity of infection), Angiostrongylus vasorum (reduces the intensity of infection), Dirofilaria immitis (for prophylactic purposes).

APPLICATION

Milbemax tablets for dogs are used once during feeding in a crushed form with a small amount of food or injected forcibly onto the root of the tongue after feeding in a minimum therapeutic dose of 0.5 mg milbemycin oxime + 5 mg praziquantel per 1 kg of animal weight, based on:

Animal weight Dosage

5-10kg 1 tablet

10-25kg 1 tablet

25-50kg 2 tablets

50-75kg 3 tablets

A preliminary fasting diet and the use of laxatives before deworming are not required.

For deworming dogs with invasion caused by Angiostrongylus vasorum, Milbemax tablets are used in the same dose four times with an interval of 7 days.

In order to prevent dirofilariasis in regions unfavorable for the disease, the drug is used in the spring-summer-autumn period: before the start of flight of mosquitoes and mosquitoes (carriers of the pathogen D. immitis) once, then once a month and the last time in the season no earlier than 1 month after the end of the flight of insects. Before deworming, you should consult a veterinarian to exclude the presence of microfilariae in the animal's blood.

With significant overdose, some dogs may experience depression, drooling, muscle paresis, tremors, and / or an uneven gait. These symptoms disappear spontaneously within 24 hours and do not require the use of drugs.

SPECIAL INSTRUCTIONS

Milbemax tablets for dogs should not be used in conjunction with other macrocyclic lactones.

CONTRAINDICATIONS

Increased individual sensitivity of the animal to the components of the drug (including a history) and severe renal and liver dysfunction.

Depleted and sick with infectious diseases animals are not subject to deworming. Do not use in puppies under 2 weeks of age and dogs weighing less than 5 kg. It is not recommended to use the drug in collie, bobtail and sheltie puppies, due to the increased sensitivity of these breeds to macrocyclic lactones. For pregnant and lactating bitches, Milbemax tablets for dogs are used under the supervision of a veterinarian.

SIDE EFFECTS

When using the drug in accordance with this instruction, side effects and complications, as a rule, are not observed. In some dogs with increased species or individual sensitivity to the components of the drug, allergic reactions may develop; in these cases, the animal is prescribed desensitizing agents.

PRECAUTIONS

When using Milbemax tablets for dogs, you should follow the general rules of personal hygiene and safety measures provided for when working with drugs. When working with the drug, it is prohibited to drink, smoke and eat. After handling the preparation, wash your hands thoroughly with soap and water.

FIRST AID MEASURES

In case of accidental ingestion of the drug inside, the victim should be given a few glasses of warm water to drink, if necessary, contact a medical institution (with a label or instructions for use). There are no antidotes.

STORAGE

In the manufacturer's sealed packaging in a dry, dark place, out of reach of children and animals, separately from food and feed, at a temperature of 5 В° C to 25 В° C. The shelf life of the drug, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of manufacture; after opening the blister - no more than 1 month. It is prohibited to use the medicinal product after the expiration date.

PACKING

Produced packaged in 2 tablets in foil blisters, which are packed in cardboard boxes.

Specifications

KolVUP

24

Manufacturer

Elanco

Teaser

prescribed to dogs for prophylactic and therapeutic purposes in case of nematodes, cestodoses, for the prevention of dirofilariasis