Midzo drops for oral administration 60mg / ml, 15 ml No. 4

It is used to treat patients with chronic alcoholism and relapse prevention.

Treatment is prescribed after a thorough examination of the patient and warning of the consequences and complications.
The drug is administered orally in 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual scheme.

Active ingredient:
Cyanamide - 60.0 mg;

Excipients:
Sorbic acid - 0.2 mg, acetic acid - 0.47 mg, sodium acetate trihydrate - 0.47 mg, purified water - up to 1.0 ml.

Severe heart disease, respiratory tract and kidney disease with decreased functions, severe liver disease, pregnancy, breastfeeding, increased individual sensitivity to the drug.

Trade name:

MIDZO

Grouping name:

Cyanamide

Dosage form:

oral drops

Composition:

Active ingredient:
Cyanamide - 60.0 mg;

Excipients:
Sorbic acid - 0.2 mg, acetic acid - 0.47 mg, sodium acetate trihydrate - 0.47 mg, purified water - up to 1.0 ml.

Description:

a clear, colorless solution with a faint odor of acetic acid.

Pharmacotherapeutic group:

remedy for the treatment of chronic alcoholism

Pharmacological properties

Pharmacodynamics
The action of cyanamide is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to an increase in the concentration of the ethyl alcohol metabolite - acetaldehyde, which causes negative sensations (flushing, nausea, tachycardia, shortness of breath, etc.), which make alcohol consumption extremely unpleasant after taking the drug. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.

The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the effect of disulfiram.

Indications for use

It is used to treat patients with chronic alcoholism and relapse prevention.

Contraindications

Severe heart disease, respiratory tract and kidney disease with decreased functions, severe liver disease, pregnancy, breastfeeding, increased individual sensitivity to the drug.

Application during pregnancy and during breastfeeding

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Method of administration and dosage

Treatment is prescribed after a thorough examination of the patient and warning of the consequences and complications.
The drug is administered orally in 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual scheme.

Side effect

As a rule, the drug is well tolerated if alcohol is not consumed. Sometimes fatigue, drowsiness, skin rashes, tinnitus, transient leukocytosis are possible.

Overdose

Overdose symptoms are not described; side effects may increase. In case of taking too large doses of the drug, gastric lavage is recommended and the appointment of symptomatic treatment aimed at maintaining the functions of the liver, respiration and cardiovascular system, it is also necessary to monitor the hematocrit and, if necessary, blood transfusion.

Alcohol reaction

While taking the drug with alcohol, the following symptoms appear: severe hyperemia of the skin, 'pulsation' in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, profuse sweating, chest pain. In the most severe cases - vomiting, lowering blood pressure, respiratory depression, collaptoid state. The nature and severity of symptoms depend on the amount of alcohol and drug consumed. In severe cases, it is necessary to carry out symptomatic therapy aimed at maintaining the functions of the respiratory and cardiovascular systems, intravenous infusion of antihistamines.

Interaction with other medicinal products

MIDZO is not prescribed together with metronidazole, isoniazid, phenotoin and other inhibitors of aldehyde dehydrogenase, which can enhance the reaction with alcohol. After taking disulfiram, before prescribing MIDZO. there must be a break of at least 10 days.
MIDZO is not compatible with drugs of the aldehyde group (paraldehyde and chloral products).

special instructions

MIDZO should only be used under medical supervision and with the knowledge of the patient. You may experience a reaction to alcohol contained in some drugs and foods.

Treatment with MIDZO can only be started 12 hours after the last alcohol intake. Cyanamide should be used with caution in cases where a reaction to simultaneous intake with alcohol may entail a risk to the patient's health: with hyperthyroidism, diabetes mellitus, epilepsy, cardiovascular diseases, kidney disease. With long-term use, it is recommended to monitor the function of the thyroid gland at least once every six months.

Release form

Oral drops, 60 mg / ml.
15 ml in a brown glass bottle equipped with a dropper nozzle and a screw cap.
4 bottles are placed in a cardboard box with instructions for use.

Storage conditions

In a dark place at a temperature not exceeding 25 ? C.
Keep out of the reach of children.

Shelf life

2 years. Do not use the drug after the expiration date printed on the package.

Vacation conditions

On prescription.