Metrogyl gel for external use 1%, 30g

• acne rosacea (including post-steroidal);

• acne vulgaris;

• oily seborrhea, seborrheic dermatitis;

• trophic ulcers of the lower extremities (against the background of varicose veins, diabetes mellitus);

• poorly healing wounds;

• bedsores;

• hemorrhoids, anal fissures

For external use. MetrogylЃgel is applied to previously cleansed affected areas of the skin with a thin layer 2 times a day, in the morning and in the evening, for 3-9 weeks. If necessary, apply an occlusive dressing. The average duration of treatment is 3-4 months, the therapeutic effect is usually noted after 3 weeks of treatment.

1 gram of gel contains:
Active substance:
Metronidazole - 10.0 mg
Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer 940, edetate disodium, sodium hydroxide, propylene glycol, purified water.

Hypersensitivity to the components of the drug.

With caution,
I trimester of pregnancy, lactation.

Trade name: METROGILЃ

International non-proprietary name:

metronidazole

Dosage form:

gel for external use

Composition:

1 gram of gel contains:
Active substance:
Metronidazole 10.0 mg
Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer 940, disodium edetate, sodium hydroxide, propylene glycol, purified water.

Description: colorless to yellow homogeneous gel.

Pharmacotherapeutic group:

antimicrobial and antiprotozoal agent.

ATX code: D06BX01

Pharmacological properties
Metronidazole is a synthetic antimicrobial and antiprotozoal broad-spectrum agent from the group of imidazoles. It is active against anaerobes ( Bacteroides spp., Fusobacterium spp., Mobiluncus spp., Peptococcus spp., Peptostreptococcus spp., Clostridium, Eubacterium, Bacteroides fragilis, Prevotella ) and protozoa ( Trichomonasinalia vagolyticis .

Pharmacodynamics.
When applied topically, it has an anti-acne effect, the mechanism of which is not exactly known (it is not associated with the effect on the Demodex folliculorum mite , found in hair follicles and the secretion of the sebaceous glands, and any effect on the production of this secret).
Metronidazole for external use may have antioxidant activity. It was found that it significantly reduces the production of active oxygen, hydroxyl radicals and hydrogen peroxide by neutrophils, which are potential oxidants that can cause tissue damage at the site of inflammation. Metronidazole for external use is not effective against telangiectasias seen with rosacea.

Pharmacokinetics. Absorption is minimal; after external application of the gel, only trace amounts of the drug are found in the blood serum. Absorbed metronidazole passes through the placenta and the blood-brain barrier. The maximum concentration in the blood is up to 66 ng / ml (when applying 1 g of gel, equivalent to 7.5 mg of metronidazole).

Indications

• acne rosacea (including post-steroidal);

• acne vulgaris;

• oily seborrhea, seborrheic dermatitis;

• trophic ulcers of the lower extremities (against the background of varicose veins, diabetes mellitus);

• poorly healing wounds;

• bedsores;

• hemorrhoids, anal fissures

Contraindications
Hypersensitivity to the components of the drug.

With caution,
I trimester of pregnancy, lactation.

Method of administration and dosage
For external use. MetrogylЃgel is applied to previously cleansed affected areas of the skin with a thin layer 2 times a day, in the morning and in the evening, for 3-9 weeks. If necessary, apply an occlusive dressing. The average duration of treatment is 3-4 months, the therapeutic effect is usually noted after 3 weeks of treatment.

Side effects
When MetrogilЃ gel is applied topically, the concentration of metronidazole in the blood is very low, so the risk of developing systemic side effects is low.
Rarely can be observed: allergic reactions (urticaria, skin rash); hyperemia, peeling, slight dryness and burning of the skin, lacrimation (if the gel is applied close to the eyes).

Interaction with other medicinal products
When using MetrogilЃ gel topically, the interaction with other medicinal products is insignificant, however, caution should be exercised while prescribing with warfarin and other indirect anticoagulants (increases prothrombin time).

Overdose
There were no cases of overdose of the drug in recommended doses with external use of the drug.

Special instructions
Avoid contact with eyes. In case of contact with the eyes, the eyes should be rinsed immediately with plenty of water.

Release form
30 g in an aluminum tube. 1 tube is placed in a cardboard box along with instructions for use.

Storage conditions
At a temperature not exceeding 30? —, out of the reach of children. Do not freeze.

Shelf life is
3 years. Do not use after the expiration date printed on the package.

Dispensed from pharmacies

without recipe