meldonium | Mildronate ampoules 10%, 5 ml, 10 pcs.
Special Price
$18.43
Regular Price
$27.00
In stock
SKU
BID462055
Latin name
Mildronate
Mildronate
Latin name
Mildronate
Release form
Injection solution is clear, colorless.
Packaging
5 ml - ampoules (5) - plastic cell packaging (2) - packs of cardboard.
Pharmacological action
A drug that improves metabolism. Meldonium is a structural analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.
Under conditions of increased load, Mildronate restores the balance between delivery and oxygen demand of the cells, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage and also has a tonic effect.
As a result of its use, the body acquires the ability to withstand the load and quickly restore energy reserves. Due to these properties, Mildronate is used to treat various disorders of the cardiovascular system, blood supply to the brain, as well as increase physical and mental performance.
As a result of a decrease in carnitine concentration, gamma-butyrobetaine with vasodilating properties is intensely synthesized. In acute ischemic myocardial damage, Mildronate slows the formation of the necrotic zone, shortens the rehabilitation period.
In heart failure, the drug increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks.
In acute and chronic ischemic disorders of cerebral circulation, improves blood circulation in the focus of ischemia, promotes redistribution of blood in favor of the ischemic site.
Effective with vascular and dystrophic fundus pathology.
The drug eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal symptoms.
Pharmacokinetics
After iv administration, the bioavailability of the drug is 100%. Cmax in plasma is reached immediately after its administration.
Metabolized in the body to form two major metabolites that are excreted by the kidneys. T1 / 2 is 3-6 hours.
Indications of
as part of the complex therapy of coronary heart disease (angina pectoris, myocardial infarction), chronic heart failure
as part of the complex therapy of acute and chronic cerebrovascular diseases (strokes and cerebrovascular insufficiency)
reduced performance of the syndrome of alcohol syndrome alcohol therapy)
hemophthalmus, retinal hemorrhages of various etiologies
thrombosis of the central retinal vein and its branches
retinopathy ra different etiology (diabetic, hypertonic).
Contraindications
increased intracranial pressure (including in violation of the venous outflow, intracranial tumors)
hypersensitivity to the drug.
Use with caution in diseases of the liver and / or kidneys, especially for a long time.
Use during pregnancy and lactation
The safety of the use of Mildronate during pregnancy has not been proven. In order to avoid a possible adverse effect on the fetus, the drug should not be prescribed during pregnancy.
It is not known whether this drug is excreted in breast milk. If it is necessary to use Mildronate during lactation, breastfeeding should be discontinued.
Composition of
1 ml of solution contains:
active ingredient - meldonium dihydrate 100 mg
excipient - water for injection.
Dosage and administration of
In connection with the possibility of developing an exciting effect, the drug is recommended to be used in the morning.
In case of cardiovascular diseases as part of complex therapy, the drug is prescribed at a dose of 0.5-1 g / day iv (5-10 ml of an injection solution with a concentration of 500 mg / 5 ml), the frequency of use is 1-2 times / day . The course of treatment is 4-6 weeks.
In case of cerebrovascular accident in the acute phase, the drug is administered iv 500 mg 1 time / day for 10 days, then they switch to taking the drug inside (in the appropriate dosage form - 0.5-1 g / day). The general course of therapy is 4-6 weeks.
For vascular pathology and dystrophic diseases of the retina, Mildronate is administered parabulbarly in a 0.5 ml solution for injection with a concentration of 500 mg / 5 ml for 10 days.
For mental and physical exertion, an iv dose of 500 mg is prescribed 1 time / day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.
In chronic alcoholism, the drug is prescribed iv 500 mg 2 times / day. The course of treatment is 7-10 days.
Side effects of
From the cardiovascular system: rarely - tachycardia, changes in blood pressure.
From the side of the central nervous system: rarely - psychomotor agitation.
From the digestive system: rarely - dyspeptic symptoms.
Allergic reactions: rarely - skin itching, redness, rash, swelling.
Drug Interaction
When used together, Mildronate enhances the action of anti-anginal agents, some antihypertensive drugs, and cardiac glycosides.
Mildronate can be combined with antianginal agents, anticoagulants and antiplatelet agents, antiarrhythmic agents, diuretics, bronchodilators.
When combined with Mildronate, nitroglycerin, nifedipine, alpha-blockers, antihypertensives and peripheral vasodilators may develop moderate tachycardia, arterial hypotension (caution should be exercised when using such a combination).
overdose
Mildronate overdose has not been described, the drug is low-toxic and does not cause adverse health effects for patients
Storage conditions
At a temperature not exceeding 25 РC.
Keep out of the reach of children.
Expiration
4 years.
Do not use after the expiry date stated on the package.
Deystvuyuschee substances
meldonium
pharmacy outlets p1726 pharmacy
Prescription
Dosage Form A dosage form
GOVERNMENTAL form
dosage form
injection
Grindeks, Latvia
Mildronate
Release form
Injection solution is clear, colorless.
Packaging
5 ml - ampoules (5) - plastic cell packaging (2) - packs of cardboard.
Pharmacological action
A drug that improves metabolism. Meldonium is a structural analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.
Under conditions of increased load, Mildronate restores the balance between delivery and oxygen demand of the cells, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage and also has a tonic effect.
As a result of its use, the body acquires the ability to withstand the load and quickly restore energy reserves. Due to these properties, Mildronate is used to treat various disorders of the cardiovascular system, blood supply to the brain, as well as increase physical and mental performance.
As a result of a decrease in carnitine concentration, gamma-butyrobetaine with vasodilating properties is intensely synthesized. In acute ischemic myocardial damage, Mildronate slows the formation of the necrotic zone, shortens the rehabilitation period.
In heart failure, the drug increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks.
In acute and chronic ischemic disorders of cerebral circulation, improves blood circulation in the focus of ischemia, promotes redistribution of blood in favor of the ischemic site.
Effective with vascular and dystrophic fundus pathology.
The drug eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal symptoms.
Pharmacokinetics
After iv administration, the bioavailability of the drug is 100%. Cmax in plasma is reached immediately after its administration.
Metabolized in the body to form two major metabolites that are excreted by the kidneys. T1 / 2 is 3-6 hours.
Indications of
as part of the complex therapy of coronary heart disease (angina pectoris, myocardial infarction), chronic heart failure
as part of the complex therapy of acute and chronic cerebrovascular diseases (strokes and cerebrovascular insufficiency)
reduced performance of the syndrome of alcohol syndrome alcohol therapy)
hemophthalmus, retinal hemorrhages of various etiologies
thrombosis of the central retinal vein and its branches
retinopathy ra different etiology (diabetic, hypertonic).
Contraindications
increased intracranial pressure (including in violation of the venous outflow, intracranial tumors)
hypersensitivity to the drug.
Use with caution in diseases of the liver and / or kidneys, especially for a long time.
Use during pregnancy and lactation
The safety of the use of Mildronate during pregnancy has not been proven. In order to avoid a possible adverse effect on the fetus, the drug should not be prescribed during pregnancy.
It is not known whether this drug is excreted in breast milk. If it is necessary to use Mildronate during lactation, breastfeeding should be discontinued.
Composition of
1 ml of solution contains:
active ingredient - meldonium dihydrate 100 mg
excipient - water for injection.
Dosage and administration of
In connection with the possibility of developing an exciting effect, the drug is recommended to be used in the morning.
In case of cardiovascular diseases as part of complex therapy, the drug is prescribed at a dose of 0.5-1 g / day iv (5-10 ml of an injection solution with a concentration of 500 mg / 5 ml), the frequency of use is 1-2 times / day . The course of treatment is 4-6 weeks.
In case of cerebrovascular accident in the acute phase, the drug is administered iv 500 mg 1 time / day for 10 days, then they switch to taking the drug inside (in the appropriate dosage form - 0.5-1 g / day). The general course of therapy is 4-6 weeks.
For vascular pathology and dystrophic diseases of the retina, Mildronate is administered parabulbarly in a 0.5 ml solution for injection with a concentration of 500 mg / 5 ml for 10 days.
For mental and physical exertion, an iv dose of 500 mg is prescribed 1 time / day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.
In chronic alcoholism, the drug is prescribed iv 500 mg 2 times / day. The course of treatment is 7-10 days.
Side effects of
From the cardiovascular system: rarely - tachycardia, changes in blood pressure.
From the side of the central nervous system: rarely - psychomotor agitation.
From the digestive system: rarely - dyspeptic symptoms.
Allergic reactions: rarely - skin itching, redness, rash, swelling.
Drug Interaction
When used together, Mildronate enhances the action of anti-anginal agents, some antihypertensive drugs, and cardiac glycosides.
Mildronate can be combined with antianginal agents, anticoagulants and antiplatelet agents, antiarrhythmic agents, diuretics, bronchodilators.
When combined with Mildronate, nitroglycerin, nifedipine, alpha-blockers, antihypertensives and peripheral vasodilators may develop moderate tachycardia, arterial hypotension (caution should be exercised when using such a combination).
overdose
Mildronate overdose has not been described, the drug is low-toxic and does not cause adverse health effects for patients
Storage conditions
At a temperature not exceeding 25 РC.
Keep out of the reach of children.
Expiration
4 years.
Do not use after the expiry date stated on the package.
Deystvuyuschee substances
meldonium
pharmacy outlets p1726 pharmacy
Prescription
Dosage Form A dosage form
GOVERNMENTAL form
dosage form
injection
Grindeks, Latvia
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