Magnesium Diasporal 300 grains. d / inv. oral solution 295.7mg (package) / 5g # 20

Dosage form

Mixture of irregular granules and yellow powder

Structure

One package (5.0 g) contains:

Active substance:

Magnesium citrate 1830.0 mg (equivalent to magnesium content 295.7 mg)

Excipients: sucrose - 2341.2 mg, citric acid - 660.0 mg, sodium bicarbonate 145.0 mg, orange flavor - 22.3 mg, riboflavin (E101) - 1.5 mg.

pharmachologic effect

Magnesium is a vital element, participates in most metabolic reactions, activates enzymes, including choline and cholinesterase, and takes part in many enzymatic processes as a cofactor.

Participates in the processes of energy supply to muscles, is a membrane protector, and stabilizes the phospholipids of the cell membrane.

Magnesium is a physiological" blocker of "slow" calcium channels and is able to displace it from the binding sites.

Regulates metabolic processes, interneuronal transmission and muscle excitability, prevents the flow of calcium ions through the presynaptic membrane, reduces the amount of acetylcholine in the peripheral nervous system and central nervous system (CNS).

Pharmacokinetics

Absorption of magnesium occurs in a dose-dependent manner, mainly in the small intestine. The amount of absorption depends on the concentration of magnesium in the blood serum. The unabsorbed portion may have a laxative effect. With malabsorption syndrome and eating foods rich in fats, the absorption of magnesium is reduced. Magnesium is excreted by the kidneys.

The serum contains about 1% of absorbed magnesium (0.8 - 1.0 mmol / l).

Of these, about 45% of magnesium binds to albumin.

Ionized magnesium has physiological activity.

Approximately half of all magnesium is localized inside cells, the other half in bones.

The value of whey magnesium is subject to daily fluctuations.

Since an equilibrium is maintained between the concentration of magnesium in the blood serum and its content in the bones, magnesium deficiency cannot be judged from the serum magnesium concentration.

Magnesium deficiency may be indicated by impaired neuromuscular excitability.

Side effects

The frequency of occurrence of adverse reactions is determined as follows:

very often (> 1/10), often (> 1/100 and < 1/10), infrequently (> 1/1000 and < 1/100), rarely (> 1 \ 10,000 and < 1/1000) , very rare (< 1/10 000, including isolated cases), the frequency is unknown (it is not possible to estimate the frequency of occurrence based on the available data)

From the gastrointestinal tract:

Uncommon: loose stools before diarrhea at the start of treatment (usually disappears with continued treatment without specific treatment).

From the nervous system:

Very rare: weakness (occurs with prolonged use of the drug).

If such an undesirable reaction occurs, the administration of Magnesium Diasporal® 300 should be discontinued.

After improvement of the condition, drug therapy can be resumed at a reduced dosage.

Frequency unknown: allergic reactions, including skin reactions, abdominal pain, nausea, flatulence.

If any of the side effects indicated in the instructions are aggravated or you notice any other side effects that are not indicated in the instructions, inform your doctor.

Selling features

Available without a prescription

Special conditions

The drug does not affect the ability to control machines and mechanisms.

Overdose

Overdose symptoms: decreased blood pressure, nausea, vomiting, slow reflexes, respiratory depression, coma, cardiac arrest, anuria.

Treatment: IV injection of calcium and / m or subcutaneous injection of 1-2 ampoules (0.5-1 mg / ml) of neostigmine methyl sulfate

IV or oral administration of 0.9% sodium chloride

in case of renal failure, hemodialysis or peritoneal dialysis.

Indications

Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as irritability, is insignificant

Name ENG

MAGNESIUM-DIASPORAL 300

Clinical and pharmacological group

Magnesium preparation

ATX code

Magnesium citrate

Dosage

295.7mg x 5g

Structure

One package (5.0 g) contains: Active ingredient: Magnesium citrate 1830.0 mg (equivalent to the magnesium content of 295.7 mg).

Excipients: sucrose - 2341.2 mg, citric acid - 660.0 mg, sodium bicarbonate 145.0 mg, orange flavor - 22.3 mg, riboflavin (E101) - 1.5 mg.

Indications

Magnesium deficiency, accompanied by such symptoms as: minor sleep disturbances, increased irritability, mild anxiety, increased fatigue, spasm of the calf muscles.

Contraindications

Increased individual sensitivity to the components of the drug Magnesium Diasporal 300, severe renal failure, atrioventricular block, myasthenia gravis, hypermagnesemia, children under 12 years of age.

Due to the presence of sucrose in the preparation, Magnesium - Diasporal 300 is contraindicated in cases of fructose intolerance, syndrome of impaired absorption of glucose or galactose, or deficiency of sucrase isomaltase.

Carefully.

Moderate renal failure (risk of developing hypermagnesemia).

Storage conditions and periods

At a temperature of 15-25 degrees.

Expiration date: 3 years

INN / Active ingredient

magnesium citrate

Specifications

Category

Laxatives

Scope of the drug

Vitamins

Release form

Granules

Manufacturer country

Germany

Package quantity, pcs

twenty

Minimum age from

18 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Protina Pharmaceutische

The amount of the dosage form in the primary package

5 g

Primary packaging type

Package

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Magnesium drug

Anatomical and therapeutic characteristics

A12CC04 Magnesium citrate

Dosage form

Granules for preparation of oral solution

Dosage (volume) of the substance in the preparation

1830 mg

Expiration date in days

1095

Package weight, g

45

Mode of application

:

Inside.

Adults 1 sachet daily.

Dissolve the contents of 1 packet in 1/2 cup of fruit juice, tea or water.

The average duration of treatment is 1 month.

Treatment should be discontinued after blood magnesium levels return to normal.

Information on technical characteristics, delivery set, country of manufacture "