Magnerot tablets 500mg, no. 50

Identified magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as:

- increased irritability,

- minor sleep disturbances,

- gastrointestinal cramps,

- increased fatigue,

- pain and muscle spasms,

- tingling sensation in the muscles.

If after a month of treatment there is no improvement in these symptoms, continued treatment is impractical.

The tablets are taken orally before meals with a little water.

2 tablets 3 times a day for 7 days, then 1 tablet 2-3 times a day daily.

The duration of the course of treatment is 4 weeks.

Treatment should be discontinued immediately after normalization of blood magnesium concentration.

Active substance :

magnesium orotate dihydrate - 500 mg;

Excipients :

colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, corn starch, povidone-K30, lactose monohydrate, sodium cyclamate, talc, magnesium stearate.

• Hypersensitivity to the components of the drug,

• urolithiasis disease,

• impaired renal function,

• predisposition to the formation of calcium-magnesium-ammonium-phosphate stones,

• myasthenia gravis,

• atrioventricular block,

• cirrhosis of the liver with ascites,

• children under 18 years of age,

• lactose intolerance,

• lactose deficiency or glucose-galactose malabsorption (due to the presence of lactose in the composition).

Pharmacodynamics

Magnesium preparation. It is the most important macronutrient, magnesium carries out more than 300 enzymatic reactions, regulation of cell permeability and neuromuscular excitability. It is necessary for the provision of many energy processes, it is involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curariform effect on the endings of cholinergic neurons, with a decrease in acetylcholine release; magnesium and calcium interact partly synergistically in the body; however, when competitively inhibiting calcium, magnesium can also affect its binding sites as a 'physiological calcium antagonist'.

Pharmacokinetics

Approximately 35-40% of the dose taken is absorbed. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid salts helps to improve the absorption of magnesium. Magnesium is excreted by the kidneys, excretion decreases with magnesium deficiency and increases with its excess.

Application during pregnancy and during breastfeeding

MagnerotЃ can be used during pregnancy only on the recommendation of a doctor. Magnesium passes into breast milk. Avoid using the drug during breastfeeding. The use of the drug during pregnancy and lactation is possible if the potential benefit to the mother outweighs the potential risk to the fetus and child.

Side effect

The frequency of occurrence of adverse reactions cannot be determined from the available data.

Disturbances from the gastrointestinal tract: unstable stools and diarrhea, which disappear on their own with a decrease in the dose of the drug.

From the immune system: allergic reactions.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor.

Overdose

With normal kidney function, ingestion of magnesium does not cause toxic reactions. Magnesium poisoning can develop with kidney failure. Toxic effects mainly depend on the concentration of magnesium in the blood serum. Symptoms: decreased blood pressure, nausea, vomiting, depression, slow reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome.

Treatment: rehydration, forced diuresis, with renal failure, hemodialysis or peritoneal dialysis is required.

Interaction with other medicinal products

With the simultaneous administration of magnesium-containing drugs with iron preparations, sodium fluoride and tetracyclines, the absorption of the latter may decrease. In addition, aminoquinolines, quinidine, penicillamine should not be administered simultaneously with magnesium preparations. Therefore, these drugs should be taken at intervals of 2-3 hours. Oral contraceptives, diuretics, muscle relaxants, glucocorticosteroids, insulin reduce the effect of the drug. Magnesium should be used with caution if you are taking magnesium-containing medications such as antacids or laxatives, or potassium-sparing diuretics or medications containing calcium. With simultaneous use with preparations containing aluminum, the absorption of aluminum in the body can be increased. Magnesium should be used with caution when used simultaneously with digitalis preparations,since the simultaneous use can interfere with the absorption of digitalis drugs. Certain antibiotics (aminoglycosides), cisplatins and cyclosporin A can lead to increased excretion of magnesium. Certain diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprazole and pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B can cause magnesium deficiency and thus reduce the effect of MagnerotЃ.rapamycin and amphotericin B can cause magnesium deficiency and thus reduce the effect of MagnerotЃ.rapamycin and amphotericin B can cause magnesium deficiency and thus reduce the effect of MagnerotЃ.

special instructions

The drug contains lactose monohydrate, therefore its use is not recommended for patients with hereditary galactosemia, glucose and galactose malabsorption syndrome or lactase deficiency.

Influence on the ability to drive vehicles, mechanisms

The drug does not affect the ability to drive vehicles and work with mechanisms.