Macmiror Vaginal Capsule Complex, No. 8

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BIDL3178852
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Russian Pharmacy name:

Макмирор Комплекс капсулы вагинальные, №8

Macmiror Vaginal Capsule Complex, No. 8

Complex therapy of vulvovaginal infections caused by pathogens sensitive to the drug: bacteria, Trichomonas, Candida fungi and chlamydia.

Vaginal suppositories: 1 vaginal suppository is administered daily in the evening before going to bed for 8 days or as recommended by a physician. If necessary, treatment can be repeated after menstruation.
For maximum therapeutic effect, insert the suppository into the upper part of the vagina.
Suppositories are not used for treatment in childhood.

Each suppository contains:
Active ingredients: nifuratel 500 mg + nystatin 200,000 ME;
Inactive substances: dimethylpolysiloxane AK1000 (Dimethicone);
Capsule composition: gelatin, glycerin (glycerol), sodium ethyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, titanium dioxide, yellow iron oxide.

Hypersensitivity to one of the active ingredients or any auxiliary ingredient of the drug.

Trade name of the drug: Macmiror complex

International non-proprietary name or group name: -

Dosage form:

vaginal cream;
vaginal suppositories

Composition:

100 g of cream contains:
Active ingredients: nifuratel 10 g + nystatin 4,000,000 ME;
Inactive substances: xalifin 15, sodium methyl parahydroxybenzoate, sodium propyl para-hydroxybenzoate, glycerin (glycerol), sorbitol solution 70%, propylene glycol, carbomer, triethanolamine 30%, purified water to 100g.
Each suppository contains:
Active ingredients: nifuratel 500 mg + nystatin 200,000 ME;
Inactive substances: dimethylpolysiloxane AK1000 (Dimethicone);
Capsule composition: gelatin, glycerin (glycerol), sodium ethyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, titanium dioxide, iron oxide yellow.

Description:
vaginal cream - a liquid homogeneous cream of yellow color;
vaginal suppositories - soft gelatinous egg-shaped suppositories of yellow color with a brown tint, containing a yellow oily suspension.

Pharmacotherapeutic group : antimicrobial combined agent (antimicrobial and antiprotozoal agent + antifungal agent)

ATX code: G01AX

Pharmacological action
Antimicrobial drug for local use. It has antiprotozoal, antifungal and antibacterial effects.
Nifuratel, a nitrofuran derivative. It is highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis ).
Nystatin is an antifungal antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to cell death. Highly active against Candida albicans .
The combination of nifuratel and nystatin allows you to achieve a more pronounced antifungal action and significantly expand the spectrum of antimicrobial action.
The high efficiency and low toxicity of the components of the drug determine a wide range of its clinical use in the treatment of vaginitis of mixed etiology, in particular, the use for the prevention of mycoses caused by the specific treatment of trichomoniasis.
Macmiror complex does not violate the physiological flora, which allows you to avoid the development of dysbiosis and quickly restore the normocenosis of the vagina.

Indications for use
Complex therapy of vulvovaginal infections caused by pathogens sensitive to the drug: bacteria, Trichomonas, Candida fungi and chlamydia.

Contraindications
Hypersensitivity to one of the active ingredients or any auxiliary ingredient of the drug.

Method of administration and dosage regimen
The drug is for local use in gynecological or venereal diseases.
Vaginal suppositories: 1 vaginal suppository is injected daily in the evening before going to bed for 8 days or as recommended by a physician. If necessary, treatment can be repeated after menstruation.
For maximum therapeutic effect, insert the suppository into the upper part of the vagina.
Suppositories are not used for treatment in childhood; it is recommended to use vaginal cream complete with an applicator (graduated syringe).
Vaginal cream: 2.5 g of cream once or twice a day, in the evening or in the morning, as recommended by your doctor, for 8 days.
The required dose of cream should be administered using a graduated applicator.

Instructions for use of the graduated applicator
Screw the graduated applicator onto the tube of cream. Draw up the required amount of cream (in accordance with the scale lines indicating the amount in grams) by pressing on the tube. Disconnect from the tube, insert into the vagina, squeeze out the contents of the applicator, pressing on the rod.
The presence of a special nozzle allows you to inject the cream without damaging the hymen. To do this, it is necessary to remove the cannula from the upper part of the rod and screw it onto the syringe head from the opposite side before inserting the cream into the vagina.

Side effect
In rare cases, allergic reactions such as skin rash or itching are possible.

Overdose
No cases of drug overdose have been reported.

Interaction with other medicinal products
Clinically significant interaction of the drug McMiror complex with other medicinal products has not been established.

Special instructions
It is necessary to carry out simultaneous treatment of the sexual partner because of the danger of re-infection. During the period of drug treatment, sexual intercourse should be avoided.

Application during pregnancy and lactation
There are no contraindications to the use of the drug during pregnancy and lactation (breastfeeding).

Influence on the ability to drive a car or other mechanisms
The use of the drug does not affect the ability to drive vehicles, engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Release form:

vaginal cream - 30 g of cream in an aluminum tube complete with an applicator (graduated syringe) and instructions for use are placed in a cardboard box.
vaginal suppositories - the blister contains 8 or 12 vaginal suppositories; 1 blister with instructions for use is placed in a cardboard box.

Shelf life
vaginal cream - 3 years;

vaginal suppositories - 3 years.
The drug should not be used after the expiration date indicated on the package.

Storage conditions
List B.
vaginal cream - store in a dark place at a temperature not exceeding 25 ? C.
vaginal suppositories - store in a dry place at a temperature not exceeding 25 ? C.
Keep out of the reach of children!

Terms of dispensing from pharmacies
Leave on prescription.

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