Lugol spray, 25 g

For topical use:

chronic tonsillitis,

atrophic rhinitis,

purulent otitis media,

trophic and varicose ulcers,

wounds,

infected burns

fresh thermal and chemical burns of I-II degree.

The drug is used 4-6 times a day to irrigate the mucous membrane of the mouth, pharynx, pharynx, spraying a spray with one press of the spray head. At the time of injection, it is recommended to hold your breath. Avoid contact with eyes. If this happens, the eyes should be flushed with plenty of water or sodium thiosulfate solution.

Active substance:

Iodine

Excipients: potassium iodide, glycerol, purified water

Hypersensitivity to iodine.

pharmachologic effect

Elemental iodine has pronounced antimicrobial properties. Elemental iodine preparations are characterized by a pronounced local irritating effect on tissues, and in high concentrations - a cauterizing effect. Local action is due to the ability of elemental iodine to precipitate tissue proteins. Preparations that split off elemental iodine have a much less pronounced irritant effect, and iodides have local irritating properties only in very high concentrations. The nature of the resorptive action of elemental iodine and iodide preparations is the same. The most pronounced effect of the resorptive action of iodine preparations is on the function of the thyroid gland. With iodine deficiency, iodides contribute to the restoration of impaired synthesis of thyroid hormones.With a normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, the sensitivity of the thyroid gland to the TSH of the pituitary gland decreases and its secretion by the pituitary gland is blocked. The effect of iodine preparations on metabolism is manifested by the intensification of dissimilation processes. In atherosclerosis, they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, they increase the fibrinolytic and lipoproteinase activity of blood serum and slow down the rate of blood coagulation. Accumulating in syphilitic gums, iodine promotes their softening and resorption. However, the accumulation of iodine in tuberculous foci leads to an increase in the inflammatory process in them. The release of iodine by the excretory glands is accompanied by irritation of the glandular tissue and increased secretion.This is due to the expectorant effect and stimulation of lactation (in small doses). However, in large doses, iodine preparations can inhibit lactation.

Pharmacokinetics

Upon contact with the skin or mucous membranes, 30% turns into iodides, and the rest into active iodine. Partially absorbed. The absorbed part penetrates into tissues and organs, is selectively absorbed by the thyroid gland. It is excreted mainly by the kidneys, intestines, sweat and mammary glands.

Side effect

When applied externally: rarely - skin irritation; with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).

Application during pregnancy and lactation

Contraindicated for oral administration during pregnancy.

Application for impaired renal function

With nephritis and nephrosis, it is contraindicated for oral administration.

special instructions

With prolonged use, the phenomena of iodism are possible.

Drug interactions

Pharmaceutically incompatible with essential oils, ammonia solutions, white sedimentary mercury (an explosive mixture is formed). An alkaline or acidic environment, the presence of fat, pus, blood weaken the antiseptic activity. Weakens the hypothyroid and strumogenic effect of lithium preparations.