Lozap Plus tablets p / o 50mg + 12.5 mg, No. 30

- Arterial hypertension (in patients for whom combination therapy is optimal);
- Reducing the risk of cardiovascular disease and mortality in patients with arterial hypertension and left ventricular hypertrophy.

Lozap Plus is taken orally, regardless of food intake.
The dosage and course of treatment is selected by the attending physician, depending on the indications for use.

Hydrochlorothiazide Losartan

- hypersensitivity to the components of the drug;
- anuria;
- severe arterial hypotension;
- severe violations of the liver and kidneys
- hypovolemia (including against the background of high doses of diuretics);
- pregnancy and lactation period;
- age up to 18 years (efficacy and safety have not been established).

Pharmacological action
Lozap Plus has a hypotensive effect.
Indications
- Arterial hypertension (in patients for whom combination therapy is optimal);
- Reducing the risk of cardiovascular disease and mortality in patients with arterial hypertension and left ventricular hypertrophy.
Contraindications
- hypersensitivity to the components of the drug;
- anuria;
- severe arterial hypotension;
- severe violations of the liver and kidneys
- hypovolemia (including against the background of high doses of diuretics);
- pregnancy and lactation period;
- age up to 18 years (efficacy and safety have not been established).
Method of administration and dosage
Lozap Plus is taken orally, regardless of food intake.
The dosage and course of treatment is selected by the attending physician, depending on the indications for use.
Side effects Side effects
are limited to those previously observed with losartan potassium and / or hydrochlorothiazide. The most common side effects of essential hypertension are dizziness.
With the development of side effects, their nature is transient, therefore, drug withdrawal is usually not required. The following phenomena may rarely disturb: drowsiness, anxiety, memory disorder, depression, paresthesia, tremor, hypesthesia, migraine, hearing impairment, bronchitis, dyspnea, rhinitis, abdominal pain, nausea, diarrhea, dry mouth, gastritis, vomiting, toothache , flatulence, back pain, limbs, chest pain; convulsions, myalgia, arthritis, arthralgia, shoulder pain, tachycardia or bradycardia, angina pectoris, arrhythmia, anemia.
Overdose
Symptoms: losartan - a marked decrease in blood pressure, tachycardia, bradycardia (as a result of vagal stimulation). Hydrochlorothiazide - loss of electrolytes (hypokalemia, hyperchloremia, hyponatremia), as well as dehydration resulting from excessive diuresis.
Treatment: symptomatic and supportive therapy. If the drug has been recently taken, the stomach should be flushed; if necessary, correction of water-electrolyte disturbances is carried out.
Losartan and its active metabolites are not removed by hemodialysis.