Lordestin tab. p / o film. 5mg # 10
Package quantity, pcs:
ten
thirty
Category
Allergy
Scope of the drug
General
Release form
Tablet
Manufacturer country
Russia
Package quantity, pcs
ten
Release form, composition and packaging
Film-coated tablets, yellow, round, biconvex
at the break - white or almost white.
1 tab.
desloratadine hemisulfate 5.788 mg,
- which corresponds to the content of desloratadine 5 mg
microcrystalline cellulose, calcium hydrogen phosphate dihydrate, pregelatinized starch, colloidal silicon dioxide, magnesium stearate.
Film casing: opadry AMB yellow 80W22099 (polyvinyl alcohol partially hydrolyzed, titanium dioxide, talc, soy lecithin, aluminum varnish based on quinoline yellow dye, xanthan gum, iron oxide yellow, aluminum varnish based on indigo carmine dye).
10 pieces.
- contour cell packaging (1) - cardboard packs.
10 pieces.
- contour cell packages (3) - cardboard packs.
pharmachologic effect
Long-acting antihistamine. It is the primary active metabolite of loratadine. Inhibits the cascade of reactions of allergic inflammation, incl. - release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of proinflammatory chemokines (RANTES), production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of such molecules as adhesion selectin, IgE-mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has an antipruritic and anti-exudative effect, reduces capillary permeability, prevents the development of tissue edema and smooth muscle spasm.
The drug has no effect on the central nervous system, has practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions.
In clinical and pharmacological studies of the use of desloratadine in the recommended therapeutic dose, there was no prolongation of the QT interval on the ECG.
The action of the drug Lordestin begins within 30 minutes after ingestion and lasts for 24 hours.
Pharmacokinetics
Suction
Desloratadine is well absorbed in the digestive tract.
Determined in blood plasma 30 minutes after ingestion.
Cmax in blood plasma is reached, on average, 3 hours after administration.
Distribution
Does not penetrate the BBB.
Plasma protein binding is 83-87%.
When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, there was no clinically significant cumulation of the drug.
Simultaneous intake of food or grapefruit juice does not affect the distribution of desloratadine when used in a dose of 7.5 mg 1 time / day.
Metabolism
Desloratadine is not an inhibitor of isoenzymes CYP3A4 and CYP2D6 and is not a substrate or inhibitor of P-glycoprotein.
It is extensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide.
Withdrawal
Only a small fraction of the oral dose is excreted by the kidneys (< 2%) and through the intestines (< 7%).
T1 / 2 is 20-30 hours (on average - 27 hours).
Indications for use
- Allergic rhinitis (relief or elimination of sneezing, nasal congestion, nasal mucus discharge, itching in the nose, itchy palate, redness and itching of the eyes, watery eyes)
- urticaria (reduction or elimination of itching, rash).
Contraindications for use
- hypersensitivity to desloratadine, other components of the drug, peanuts, soybean oil or loratadine
- pregnancy
- the period of breastfeeding
- children under 12 years old.
Precautions: severe renal impairment.
Dosage regimen
Inside.
For adults and children 12 years and older, the drug is prescribed in a dose of 5 mg (1 tab.) 1 time / day.
The drug is recommended to be taken at the same time of day, regardless of the meal, with a small amount
Name ENG
LORDESTIN
Clinical and pharmacological group
Blocker of histamine H1 receptors.
Antiallergic drug
ATX code
Desloratadine
Dosage
5mg
Structure
Active ingredient: desloratadine hemisulfate 5.788 (equivalent to 5 mg desloratadine)
Excipients: MCC - 39 mg
calcium hydrogen phosphate dihydrate - 46.712 mg
pregelatinized starch - 7 mg
colloidal silicon dioxide (aerosil) - 0.5 mg
magnesium stearate - 1 mg
Film casing: Opadry AMB yellow 80W22099 (partially hydrolyzed polyvinyl alcohol, titanium dioxide, talc, lecithin, aluminum varnish based on quinoline yellow dye, xanthan gum, iron oxide yellow, aluminum varnish based on indigo carmine dye)
Indications
Seasonal allergic rhinitis, chronic idiopathic urticaria.
Storage conditions and periods
At a temperature not higher than 25 degrees.
Expiration date: 4 years
INN / Active ingredient
Desloratadine
Contraindications
Pregnancy, lactation, children under 2 years of age, hypersensitivity to desloratadine.
Specifications
Category
Allergy
Scope of the drug
General
Release form
Tablet
Manufacturer country
Russia
Package quantity, pcs
ten
Minimum age from
12 years
Way of introduction
Through the mouth
Vacation conditions
Without recipe
Brand name
Gedeon richter
The amount of the dosage form in the primary package
10 pieces.
Primary packaging type
Blister
Type of consumer packaging
Pack of cardboard
Anatomical and therapeutic characteristics
R06AX27 Desloratadine
Dosage form
Film-coated tablets
The target audience
Children
Expiration date in days
1460
Dosage (volume) of the substance in the preparation
desloratadine hemisulfate 5 mg
Package weight, g
15
Mode of application
:
Inside, swallowing whole, without chewing.
The drug is recommended to be taken at the same time of day, regardless of food intake, with a small amount of water.
Adults and adolescents aged 12 years and older - the drug is prescribed once a day at a dose of 5 mg (1 tablet).
With chronic renal failure and liver failure - correction of the dosage regimen is required - the initial dose of 5 mg is recommended to be taken every other day (according to pharmacokinetics).
There are no dosage recommendations in children with CRF and hepatic impairment (due to insufficient data).
Pharmaco-therapeutic group
:
Antiallergic agent - H1-histamine receptor blocker
Information on technical characteristics, delivery set, country of manufacture