Lorahexal tablets 10mg, No. 10

seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis - symptomatic treatment of sneezing, itching of the nasal mucosa, rhinorrhea, burning and itching in the eyes, lacrimation;

chronic idiopathic urticaria;

allergic skin diseases.

Inside, regardless of the time of the meal.

Inside for adults and children over 12 years old, as well as with a body weight of more than 30 kg - 10 mg 1 time / day.

Children from 2 to 12 years old with a body weight of less than 30 kg - 5 mg 1 time / day.

active substance:

loratadine

intolerance or hypersensitivity to loratadine or any other component of the drug;

rare hereditary diseases (impaired galactose tolerance, Lapp lactase deficiency or glucose-galactose malabsorption) - due to the presence of lactose, which is part of the tablets; deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption - due to the presence of sucrose, which is part of the syrup;

breastfeeding period;

age up to 2 years (for syrup), 3 years (for tablets).

Precautions: severe liver dysfunction; pregnancy (see 'Application during pregnancy and lactation').

pharmachologic effect

Blocker of histamine H1 receptors. It has antiallergic, antipruritic, antiexudative effect. Reduces capillary permeability, prevents the development of tissue edema, reduces the increased contractile activity of smooth muscles, due to the action of histamine.

Indications of the active substances of the drug

Seasonal and year-round allergic rhinitis, conjunctivitis, acute urticaria and Quincke's edema, symptoms of histaminergies caused by the use of histaminoliberates (pseudo-allergic syndromes), allergic reactions to insect bites, complex treatment of itchy dermatoses (contact allergic dermatitis, chronic eczema).

Dosage regimen

Inside for adults and children over 12 years old, as well as with a body weight of more than 30 kg - 10 mg 1 time / day.

Children from 2 to 12 years old with a body weight of less than 30 kg - 5 mg 1 time / day.

Side effect

From the digestive system: rarely - dry mouth, nausea, vomiting, gastritis; in some cases - liver dysfunction.

From the side of the central nervous system: rarely - increased fatigue, headache, irritability (in children).

From the side of the cardiovascular system: rarely - tachycardia.

Allergic reactions: rarely - skin rash; in isolated cases - anaphylactic reactions.

Dermatological reactions: in some cases - alopecia.

Contraindications for use

Pregnancy, lactation, children under 2 years of age, hypersensitivity to loratadine. Pregnancy and lactation Loratadine should not be used during pregnancy and lactation.

In experimental studies on animals, loratadine in medium doses did not have a negative effect on the fetus; when administered in high doses, some fetotoxic effects were observed.

Application for violations of liver function

Patients with impaired renal or hepatic function require a dosage adjustment.

Application for impaired renal function

Patients with impaired renal or hepatic function require a dosage adjustment. Use in children Contraindicated in children under 2 years of age.

special instructions

When using loratadine, the development of seizures cannot be completely ruled out, especially in predisposed patients.

Patients with impaired renal or hepatic function require a dosage adjustment.

Drug interactions

With the simultaneous use of loratadine with drugs that inhibit the isoenzymes CYP3A4 and CYP2D6 or are metabolized in the liver with their participation (including cimetidine, erythromycin, ketoconazole, quinidine, fluconazole, fluoxetine), a change in the plasma concentration of loratadine and / or these drugs.

Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness.