Loperamide-acriquine capsules 2mg, No. 20

Symptomatic treatment of acute and chronic diarrhea of ??various origins (allergic, emotional, medicinal, radiation; with a change in diet and quality composition of food, with metabolic and absorption disorders; as an adjunct for infectious diarrhea). Stool regulation in patients with ileostomy.

Inside, without liquid, drink with water.

Adults with acute diarrhea are initially prescribed 2 capsules (4 mg) Loperamide-Akrikhin, then 1 capsule (2 mg) after each bowel movement in the case of loose stools. The highest daily dose is 8 capsules (16 mg).

For chronic diarrhea, adults are prescribed 4 mg / day. The maximum daily dose is 16 mg.

For acute diarrhea, children over 6 years of age are prescribed an initial dose of 2 mg, then 2 mg after each act of defecation in the case of loose stools. The maximum daily dose is 4 capsules (8 mg).

For chronic diarrhea, children over 6 years of age are prescribed Loperamide-Akrikhin in a daily dose of 2 mg. The maximum daily dose is 6 mg per 20 kg.

After stool normalization or in the absence of stool for more than 12 hours, the drug should be discontinued.

1 capsule contains:
active substance - loperamide hydrochloride 2 mg;
excipients: lactose (milk sugar), corn starch, colloidal silicon dioxide (aerosil), talc, magnesium stearate. Capsule composition: titanium dioxide, quinoline yellow dye, sunset yellow dye, gelatin.

Hypersensitivity, intestinal obstruction, acute ulcerative colitis, diverticulosis, diarrhea against the background of acute pseudomembranous enterocolitis, dysentery and other infections of the gastrointestinal tract. Pregnancy (1 trimester), lactation, children under 2 years of age (Loperamide-Akrikhin capsules are not prescribed for children under 6 years of age).

Carefully

Liver failure.

Trade name of the drug:

Loperamide-Akrikhin

International non-proprietary name:

loperamide

Dosage form:

capsules

Composition:

1 capsule contains:
active substance - loperamide hydrochloride 2 mg;
excipients: lactose (milk sugar), corn starch, colloidal silicon dioxide (aerosil), talc, magnesium stearate. Capsule composition: titanium dioxide, quinoline yellow dye, sunset yellow dye, gelatin.

Description.

Capsules No. 4 are yellow. The contents of the capsules are powder of white or white yellowish shade.

Pharmacotherapeutic group:

antidiarrheal agent.

pharmachologic effect

Pharmacodynamics.
Loperamide, by binding to opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, helps to retain stool and reduce the urge to defecate. The action develops quickly and lasts 4-6 hours.

Pharmacokinetics.
When taken orally, absorption is 40%. The maximum plasma concentration is reached 2.5 hours after taking the capsules. Communication with plasma proteins (mainly with albumin) - 97%. Does not penetrate the blood-brain barrier. Almost completely metabolized by the liver by conjugation. The half-life is 9-14 hours (average 9.8 hours). It is excreted mainly with bile, a small part is excreted by the kidneys (in the form of conjugated metabolites).

Indications for use:

Symptomatic treatment of acute and chronic diarrhea of ??various origins (allergic, emotional, medicinal, radiation; with a change in diet and quality composition of food, with metabolic and absorption disorders; as an adjunct for infectious diarrhea). Stool regulation in patients with ileostomy.

Contraindications:

Hypersensitivity, intestinal obstruction, acute ulcerative colitis, diverticulosis, diarrhea against the background of acute pseudomembranous enterocolitis, dysentery and other infections of the gastrointestinal tract. Pregnancy (1 trimester), lactation, children under 2 years of age (Loperamide-Akrikhin capsules are not prescribed for children under 6 years of age).

Carefully

Liver failure.

Method of administration and dosage

Inside, without liquid, drink with water.

Adults with acute diarrhea are initially prescribed 2 capsules (4 mg) Loperamide-Akrikhin, then 1 capsule (2 mg) after each bowel movement in the case of loose stools. The highest daily dose is 8 capsules (16 mg).

For chronic diarrhea, adults are prescribed 4 mg / day. The maximum daily dose is 16 mg.

For acute diarrhea, children over 6 years of age are prescribed an initial dose of 2 mg, then 2 mg after each act of defecation in the case of loose stools. The maximum daily dose is 4 capsules (8 mg).

For chronic diarrhea, children over 6 years of age are prescribed Loperamide-Akrikhin in a daily dose of 2 mg. The maximum daily dose is 6 mg per 20 kg.

After stool normalization or in the absence of stool for more than 12 hours, the drug should be discontinued.

Side effect

It is observed, as a rule, only with prolonged use of the drug.

Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disturbances, dry mouth, intestinal colic, gastralgia, pain or discomfort in the abdomen, nausea, vomiting, flatulence are possible.

Rarely - urinary retention, extremely rarely - intestinal obstruction.

Overdose

Symptoms: signs of inhibition of the function of the central nervous system (stupor, impaired coordination of movements, drowsiness, constriction of the pupils (miosis), increased tone of skeletal muscles, respiratory depression), intestinal obstruction.
Treatment: Naloxone is used as a specific antidote. Considering that the duration of action of Loperamide-Akrikhin is longer than that of naloxone, it is possible to re-introduce the latter. Symptomatic treatment: gastric lavage, taking activated charcoal (in the first 3 hours after taking the drug), artificial ventilation.

special instructions

If there is no effect after 2 days of using Loperamide-Akrikhin, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea.

It is not recommended to prescribe in capsules for children under 6 years of age.

If constipation or bloating develops during treatment, Loperamide-Akrikhin should be canceled. In patients with impaired liver function, careful monitoring of signs of toxic damage to the central nervous system is necessary. During the period of diarrhea treatment, it is necessary to replace the loss of fluids and electrolytes.

During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Release form:

Capsules 2 mg.
10 capsules in a blister strip packaging. 1 or 2 blister packs together with instructions for use are placed in a cardboard box.

Storage conditions

In a dry, dark place at a temperature not exceeding 25 ? C.
Keep out of the reach of children.

Shelf life

4 years. Do not use the drug after the expiration date.

Terms of dispensing from pharmacies:

Without recipe.