Livial tablets 2.5mg, No. 28
Russian Pharmacy name:
Ливиал таблетки 2.5мг, №28
Menopause (natural or due to oophorectomy).
Prevention of climacteric osteoporosis.
Inside, at the same time, with water or a drink.
The drug LivialЃ is taken in 1 tab. 1 per day. The blisters are marked with the days of the week. You should start taking the drug by taking the pill marked on the current day. For example, if the day of admission coincides with Monday, then it is necessary to take the pill marked Monday from the top row of the blister. Further pills should be taken according to the days of the week. From the next blister, tablets are taken without gaps and breaks.
You should not allow missing pills between blisters or packages!
LivialЃ should not be taken until 12 months after the last natural menstrual period. If you start taking the drug LivialЃ earlier than the specified period, then the likelihood of irregular bleeding / bleeding from the vagina increases.
In case of any side effects, you should immediately consult a doctor.
If a woman has forgotten to take LivialЃ
If a woman has forgotten to take a pill, then she should be taken as soon as she remembers this, but no later than 12 hours later. If the pill is more than 12 hours overdue, then it is necessary to skip it.
Do not take a double dose to make up for a missed single dose.
Active ingredient: tibolone - 2.5 mg
Excipients : potato starch - 10 mg, magnesium stearate - 0.5 mg, ascorbyl palmitate - 0.2 mg, lactose - up to 100 mg, purified water - traces (removed during production).
Pregnancy,
hormone-dependent tumors (including suspicion of them),
thrombophlebitis,
thromboembolism (including history),
vaginal bleeding of unknown etiology,
liver failure,
cardiovascular insufficiency,
cerebrovascular disorders,
otosclerosis,
arising during pregnancy or during steroid treatment,
period less than 1 year after the last menstrual period.
Clinical and pharmacological group: Anti-climacteric drug
Pharmaco-therapeutic group: Estrogen
pharmachologic effect
Anabolic steroid. It has estrogenic, gestagenic and weak androgenic activity, stabilizes the hypothalamic-pituitary system after the cessation of ovarian function, causes a decrease in the secretion of gonadotropic hormones. It inhibits bone resorption in the postmenopausal period, alleviates such manifestations of climacteric syndrome as hot flushes of blood to the skin of the face, increased sweating, and headaches. It has a positive effect on libido and mood (increases the concentration of central and peripheral opioids). Has a stimulating effect on the vaginal mucosa without stimulating endometrial proliferation. Suppresses ovulation in fertile women.
Prevents the development of osteoporosis, reduces the concentration of phosphates and calcium in the blood serum.
Pharmacokinetics
Absorption is high. It is metabolized in the liver with the formation of hydrophilic products, some of which are pharmacologically active. It is excreted by the kidneys (including in the form of metabolites), through the intestines.
Indications
Menopause (natural or due to oophorectomy).
Prevention of climacteric osteoporosis.
Dosage regimen
The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
Inside at a dose of 2.5 mg / day (at the same time); the minimum duration of treatment is 3 months. The drug should be taken 1 year after the last menstrual period or immediately after surgical menopause.
Side effect
From the side of the central nervous system: dizziness, headache.
From the digestive system: diarrhea, increased activity of hepatic transaminases, changes in body weight.
From the endocrine system: increased facial hair growth, metrorrhagia, endometrial proliferation.
Others: swelling of the legs, seborrheic dermatosis, pain in the back, arms and legs.
Contraindications for use
Pregnancy,
hormone-dependent tumors (including suspicion of them),
thrombophlebitis,
thromboembolism (including history),
vaginal bleeding of unknown etiology,
liver failure,
cardiovascular insufficiency,
cerebrovascular disorders,
otosclerosis,
arising during pregnancy or during steroid treatment,
period less than 1 year after the last menstrual period.
Application during pregnancy and lactation
Contraindicated in pregnancy.
Application for violations of liver function
Contraindicated in liver failure.
Application for impaired renal function
Use with caution in renal impairment.
special instructions
Use with caution in renal failure, disorders of carbohydrate metabolism, hypercholesterolemia, epilepsy.
Not intended for use as a contraceptive. In the course of treatment, it is possible to increase the sensitivity of patients to anticoagulants due to an increase in the fibrinolytic activity of the blood.
When symptoms of thromboembolism, jaundice or persistent pathological changes in functional liver tests appear, treatment is discontinued.
During the treatment period, it is necessary to regularly monitor the corresponding laboratory parameters in patients with hypercholesterolemia, renal failure, diabetes mellitus. During treatment, it is possible to reduce the concentration of total and free T4 and thyroxine-binding globulin.
Drug interactions
Enhances the effect of anticoagulants.