Livarol vaginal suppositories 400mg, No. 10
Russian Pharmacy name:
Ливарол суппозитории вагинальные 400мг, №10
treatment of acute and chronic recurrent vaginal candidiasis;
prevention of fungal infections of the vagina with reduced resistance of the body and against the background of treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.
Before using the drug, vaginal suppositories should be released from the contour package.
Suppositories are injected deep into the vagina in the supine position 1 time / day for 3-5 days, depending on the course of the disease.
In chronic candidiasis , 1 suppository is prescribed for 10 days.
Active ingredient: ketoconazole - 400 mg
Excipients : butylhydroxyanisole, a mixture of macrogols (macrogol 1500, macrogol 400).
I trimester pregnancy;
hypersensitivity to the components of the drug.
The drug should be prescribed with caution in the II and III trimesters of pregnancy, during lactation, for children under 12 years old.
Clinical and pharmacological group: Antifungal drug for local use
Pharmaco-therapeutic group: Antifungal agent
pharmachologic effect
Antifungal drug from the group of imidazole dioxolane derivatives for topical use. It has a fungicidal and fungistatic effect, the mechanism of which is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.
Active against dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp.) And yeast (Candida spp., Pityrosporum spp.).
It is also active against Staphylococcus spp. and Streptococcus spp.
Pharmacokinetics
Systemic absorption with intravaginal use of the drug LivarolЃ is negligible.
Indications
treatment of acute and chronic recurrent vaginal candidiasis;
prevention of fungal infections of the vagina with reduced resistance of the body and against the background of treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.
Dosage regimen
Before using the drug, vaginal suppositories should be released from the contour package.
Suppositories are injected deep into the vagina in the supine position 1 time / day for 3-5 days, depending on the course of the disease.
In chronic candidiasis , 1 suppository is prescribed for 10 days.
Side effect
Local reactions: hyperemia and irritation of the vaginal mucosa, itching of the vagina.
Allergic reactions: skin rash, urticaria.
Contraindications for use
I trimester pregnancy;
hypersensitivity to the components of the drug.
The drug should be prescribed with caution in the II and III trimesters of pregnancy, during lactation, for children under 12 years of age.
Application during pregnancy and lactation
The drug is contraindicated in the first trimester of pregnancy.
When using the drug in the II and III trimesters of pregnancy and during lactation, caution should be exercised.
Application in children
The drug should be prescribed with caution to children under 12 years of age.
special instructions
In rare cases, allergic reactions (hyperemia of the penis) in the sexual partner are possible.
To reduce the risk of recurrence of the disease, simultaneous treatment of the sexual partner is recommended.
Overdose
Data on overdose of the drug LivarolЃ are not provided.
Drug interactions
When using Livarol with other drugs, no undesirable interaction was noted, and it is unlikely due to the low resorption capacity of ketoconazole.
Storage conditions
The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25 ? C.
Shelf life
Shelf life is 2 years.
Terms of sale
The drug is approved for use as a means of OTC.
Contacts for inquiries
STADA (Russia)