Description

Dosage form

Opaque capsules, white body - yellow cap.

Capsule content: light beige powder interspersed with yellow.

Structure

1 capsule contains:

Active ingredient: Probio-tec AB Blend 64 powder (Probio-tec® AB Blend 64) - 60,000 mg (powder contains active ingredients: Lactobacillus acidophilus (LA-5) - 13.8 mg and Bifidobacterium animalis subsp.lactis (BB-12 ) - 4.2 mg auxiliary components: anhydrous dextrose - 29.1 mg, microcrystalline cellulose - 6 mg, potato starch 6 - mg, magnesium stearate - 0.9 mg).

Excipients: Beneo Synergy 1 (Beneo® Synergy 1) - 171,500 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose))

magnesium stearate - 3,500 mg.

The composition of the capsule body: hypromellose - 33.149 mg, titanium dioxide (E 171) - 0.691 mg.

The composition of the capsule cap: hypromellose - 22.080 mg, titanium dioxide dye (E 171) - 0.240 mg, iron dye yellow oxide (E 172) - 0.240 mg.

pharmachologic effect

Linex® Forte normalizes the intestinal microflora.

One capsule of Linex Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp.lactis (BB-12)), each capsule contains 10 (9) colony-forming units of live lyophilized lactic acid bacteria.

Live lactic acid bacteria are a normal component of the natural intestinal microflora.

The main functions of lactic acid bacteria:

- protective: synthesis of substances with antibacterial activity

- enzyme-producing: hydrolysis of cellulose, proteins, fats, starch, deconjugation of bile acids, synthetic: synthesis of vitamins of group B, C, K, amino acids, organic acids, etc.

Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:

- lowering the pH in the intestine (the result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid)

- the production of metabolites that have a toxic effect on pathogenic bacteria (formation of H2O2)

- the formation of antimicrobial substances, bacteriocins (LA-5 secretes acidocin, a broad-spectrum bacteriocin that prevents the growth of bacteria and fungi)

- competition with pathogenic bacteria for nutrients

- interactions with adhesion receptors, thus preventing the colonization of other, potentially pathogenic microorganisms.

Pharmacokinetics

Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract when taken orally, the drug does not undergo systemic absorption.

Routine pharmacokinetic studies are therefore not applicable.

The resistance of LA-5 and BB-12 to the action of gastric juice and bile allows the strains to survive in large numbers when passing through the stomach and duodenum.

Both strains attach to the intestinal mucosa.

Like other microorganisms, they are gradually eliminated from the gastrointestinal tract by peristalsis and defecation.

Side effects

The drug is well tolerated.

There are no reports of adverse effects, but hypersensitivity reactions may occur.

Selling features

Available without a prescription

Special conditions

Linex® Forte should not be taken with hot drinks and taken simultaneously with alcohol.

You should consult your doctor before taking the drug if you have:

- body temperature above 38 ° C

- traces of blood or mucus in the stool

- diarrhea lasts more than two days and is accompanied by severe abdominal pain, dehydration and weight loss

- chronic diseases - diabetes mellitus, HIV infection.

When treating diarrhea, it is necessary to replace lost fluid and electrolytes.

SPECIAL PRECAUTIONS FOR DISPOSAL OF AN UNUSED MEDICINE

No need

Name ENG

LINEX FORTE

Clinical and pharmacological group

A drug that regulates the balance of intestinal microflora (probiotic)

ATX code

Preparations containing microorganisms that produce lactic acid in combination with other drugs

Dosage

60mg

Structure

Active ingredient: Probio-tec AB Blend 64 powder (Probio-tec® AB Blend 64) - 60,000 mg (powder contains active ingredients: Lactobacillus acidophilus (LA-5) - 13.8 mg and Bifidobacterium animalis subsp.lactis (BB-12 ) - 4.2 mg auxiliary components: anhydrous dextrose - 29.1 mg, microcrystalline cellulose - 6 mg, potato starch 6 - mg, magnesium stearate - 0.9 mg).

Excipients: Beneo Synergy 1 (Beneo® Synergy 1) - 171,500 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose))

magnesium stearate - 3,500 mg.

The composition of the capsule body: hypromellose - 33.149 mg, titanium dioxide (E 171) - 0.691 mg.

The composition of the capsule cap: hypromellose - 22.080 mg, titanium dioxide dye (E 171) - 0.240 mg, iron dye yellow oxide (E 172) - 0.240 mg.

Indications

Treatment and prevention of intestinal dysbiosis.

Intestinal dysbiosis is manifested by the following symptoms: diarrhea (diarrhea), dyspepsia (indigestion), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, and allergic skin reactions are possible.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 2 years

INN / Active ingredient

Lactobacillus acidophilus, Bifidobacterium animalis subsp.

lactis

Contraindications

hypersensitivity to the components of the drug

- hereditary fructose intolerance, deficiency of sucrase, isomaltase, or glucose-galactose malabsorption.,

CAREFULLY,

With caution in diabetes mellitus (the composition contains simple sugars), deficiency of the immune system (for example, HIV infection).

Diarrhea in children under 6 years of age should be treated with medical supervision.

Specifications