Lifevit (Vitamin E) capsules 400mg, No. 30

Prevention and treatment of vitamin E hypovitaminosis, including:

• degenerative and proliferative changes in the musculoskeletal system, in particular muscular dystrophy, amyotrophic lateral sclerosis (as part of complex therapy);

• chronic hepatitis (as part of complex therapy);

• the state of convalescence after serious illnesses, injuries, operations;

• heavy physical activity;

• menstrual irregularities (as part of complex therapy for hormonal treatment of menstrual irregularities).

Inside. The drug is intended for use by adult patients only.

Treatment of vitamin E hypovitaminosis - caps. 100 mg once a day until the symptoms of hypovitaminosis are eliminated.

Hypovitaminosis E, accompanied by degenerative and proliferative changes in the musculoskeletal system, in particular muscular dystrophy, amyotrophic lateral sclerosis (as part of complex therapy) - caps. 100 mg once a day for 1-2 months.

Hypovitaminosis E, accompanied by chronic hepatitis (as part of complex therapy) - caps. 100 mg once a day.

Hypovitaminosis E in conditions of convalescence after serious illnesses, injuries, operations - caps. 100 mg once a day for 1-2 weeks.

Hypovitaminosis E with increased physical activity - caps. 100 mg 1 time per day during increased physical exertion.

Hypovitaminosis E, accompanied by menstrual irregularities (as part of complex therapy for hormonal treatment of menstrual irregularities) - caps. 300-400 mg every other day sequentially, starting from the 17th day of the cycle until the last day of the cycle (the day before the first day of menstruation).

Active substance:

alpha-tocopherol acetate: 100 mg / 200 mg / 400 mg

Excipients: sunflower oil - 7.5 / 15/30 mg

Capsule shell: gelatin - 49.38 / 71.824 / 112.225 mg; glycerol 85% - 27.46 / 39.934 / 62.397 mg; methyl parahydroxybenzoate - 0.049 / 0.072 / 0.112 mg; crimson dye Ponso 4R (E124) - 0.22 / 0.319 / 0.499 mg; purified water - 32.898 / 47.851 / 74.768 mg

• Hypersensitivity to the components of the drug;

• acute myocardial infarction;

• childhood.

Carefully:

In patients with severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism; hypothrombinemia caused by vitamin K deficiency may worsen with the use of vitamin E in a dose of more than 400 IU (1 mg - 1.21 IU).

Composition:

Active substance:

alpha-tocopherol acetate: 100 mg / 200 mg / 400 mg

Excipients: sunflower oil - 7.5 / 15/30 mg

Capsule shell: gelatin - 49.38 / 71.824 / 112.225 mg; glycerol 85% - 27.46 / 39.934 / 62.397 mg; methyl parahydroxybenzoate - 0.049 / 0.072 / 0.112 mg; crimson dye Ponso 4R (E124) - 0.22 / 0.319 / 0.499 mg; purified water - 32.898 / 47.851 / 74.768 mg

Description of the dosage form

Red oval capsules filled with clear light yellow oil.

pharmachologic effect

Pharmacological action - replenishing vitamin E deficiency.

Pharmacodynamics

Biologically active tocopherols protect intermediate compounds of cellular respiration from oxidation of functional groups of their molecules. Active tocopherols are capable of being oxidized to semiquinones, which are again reduced in the body to tocopherols.

If tocopherols are present in the human body in sufficient quantities, they protect unstable mediators and metabolites of cellular respiration from oxidation.

In redox processes at the level of cellular metabolism under pathological conditions, they play a buffer role.

Vitamin E (a-tocopherol), the most effective of the tocopherols, acts in the human body as a cellular antioxidant and a substance that binds free oxygen radicals.

Vitamin E has an antioxidant effect, participates in the biosynthesis of heme and proteins, cell proliferation, and other important processes of tissue metabolism, and prevents hemolysis of erythrocytes. It is necessary for the development and functioning of connective tissue, as well as for strengthening the walls of blood vessels. It is a natural antioxidant, inhibits lipid peroxidation by free radicals. Activates phagocytosis and is used to maintain normal erythrocyte resistance. In large doses, it prevents platelet aggregation.

Pharmacokinetics

Absorption from the duodenum (requires the presence of bile salts, fats, normal functioning of the pancreas) - 20-40%. When the dose is increased, the degree of absorption decreases. Tmax - 4 hours. It is deposited in all organs and tissues, especially in adipose tissue.

Penetrates through the placenta in insufficient quantities: 20-30% of the concentration in the mother's blood penetrates into the fetal blood. Penetrates into breast milk.

Excretion mainly through the gastrointestinal tract, with bile - more than 90%, less than 6% is excreted by the kidneys in the form of glucuronides and other metabolites.

Indications

Prevention and treatment of vitamin E hypovitaminosis, including:

• degenerative and proliferative changes in the musculoskeletal system, in particular muscular dystrophy, amyotrophic lateral sclerosis (as part of complex therapy);

• chronic hepatitis (as part of complex therapy);

• the state of convalescence after serious illnesses, injuries, operations;

• heavy physical activity;

• menstrual irregularities (as part of complex therapy for hormonal treatment of menstrual irregularities).

Contraindications

• hypersensitivity to drug components;

• acute myocardial infarction;

• childhood.

Carefully:

In patients with severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism; hypothrombinemia caused by vitamin K deficiency may worsen with the use of vitamin E in a dose of more than 400 IU (1 mg - 1.21 IU).

Application during pregnancy and lactation

During pregnancy and breastfeeding, taking the drug only on the recommendation of a doctor.

Side effects

Usually, when used in recommended doses, side effects are not observed.

From the immune system: allergic reactions.

From the gastrointestinal tract: diarrhea, nausea, gastralgia.

From the side of metabolism and nutrition: hypercreatinuria, increased CPK activity, increased serum cholesterol concentration.

From the side of the vessels: thrombophlebitis, pulmonary embolism.

Interaction

Strengthens the effect of GCS, NSAIDs, cardiac glycosides.

Increases the effectiveness of antiepileptic drugs in patients with epilepsy (in whom the content of lipid peroxidation products in the blood is increased).

High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

The simultaneous use of vitamin E at a dose of more than 400 IU / day with anticoagulants (coumarin and indandione derivatives) increases the risk of developing hypoprothrombinemia and bleeding.

Vitamin E enhances the effect of anticoagulants if doses exceed 400 IU / day.

The simultaneous intake of other vitamin complexes containing vitamin E is not recommended in order to avoid overdose.

High-dose vitamin E supplementation can cause vitamin A deficiency in the body. Cholestyramine, colestipol, mineral oils reduce the absorption of vitamin E.

Method of administration and dosage

Inside. The drug is intended for use by adult patients only.

Treatment of vitamin E hypovitaminosis - caps. 100 mg once a day until the symptoms of hypovitaminosis are eliminated.

Hypovitaminosis E, accompanied by degenerative and proliferative changes in the musculoskeletal system, in particular muscular dystrophy, amyotrophic lateral sclerosis (as part of complex therapy) - caps. 100 mg once a day for 1-2 months.

Hypovitaminosis E, accompanied by chronic hepatitis (as part of complex therapy) - caps. 100 mg once a day.

Hypovitaminosis E in conditions of convalescence after serious illnesses, injuries, operations - caps. 100 mg once a day for 1-2 weeks.

Hypovitaminosis E with increased physical activity - caps. 100 mg 1 time per day during increased physical exertion.

Hypovitaminosis E, accompanied by menstrual irregularities (as part of complex therapy for hormonal treatment of menstrual irregularities) - caps. 300-400 mg every other day sequentially, starting from the 17th day of the cycle until the last day of the cycle (the day before the first day of menstruation).

Overdose

Symptoms: high doses of vitamin E (400-800 mg / day for a long time) can cause visual impairment, diarrhea, dizziness, headache, nausea, severe fatigue, fainting, white hair growth in areas of alopecia with epidermolysis bullosa. Very high doses (exceeding 800 mg for a long time) can cause bleeding in patients with vitamin K deficiency; they can disrupt thyroid hormone metabolism and increase the risk of thrombophlebitis and thromboembolism in sensitive patients.

Treatment: symptomatic, drug withdrawal, GCS prescription.

special instructions

With congenital epidermolysis bullosa, white hair may begin to grow in areas affected by alopecia.

The lack of vitamin K in the body, causing hypoprothrombinemia, can increase with the use of high doses of vitamin E (more than 400 IU / day). Vitamin E enhances the effect of anticoagulants if doses exceed 400 IU / day. In order to avoid its overdose, it is not recommended to take other vitamin complexes containing vitamin E at the same time.

Influence on the ability to drive vehicles or mechanisms.

Taking Vitamin E capsules does not affect a person's ability to drive vehicles or mechanisms.

Release form

Capsules, 100, 200, 400 mg.

Capsules 100 mg, 200 mg: 30 capsules in dark glass vials.

Capsules 400 mg: 20 or 30 capsules in dark glass vials.

Each bottle is placed in a cardboard box.

Conditions of dispensing from pharmacies

Without recipe.

Storage conditions

At a temperature of 15-25 ? C. (in original packaging)

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiration date printed on the package.